Innovation Timeline
Biotechnology
PCR, CRISPR, recombinant DNA, monoclonal antibodies — the landmark patents behind modern biotechnology and the therapies they enabled.
Landmark patents
277
Total citations
52,391
Span
1885 – 2026
Milestones
56
1920s
Leonarde Keeler's Early Mechanical Blood Pressure Recorder
A 1925 invention by Leonarde Keeler designed to mechanically record a patient's arterial blood pressure over time.
4 citations
The Invention of the Modern Adhesive Bandage
A 1926 patent by Johnson and Johnson for the first mass-produced, sterile adhesive bandage, commonly known as the Band-Aid.
16 citations
1930s
How the Iron Lung Artificial Respirator Works
A 1933 patent for a mechanical respirator that uses external air pressure changes to force a patient's lungs to expand and contract.
7 citations
How the modern internal menstrual tampon was invented
Earle Haas's 1933 patent describes the first modern internal menstrual tampon, designed to be inserted into the vagina using a cardboard applicator.
36 citations
How Arnold Beckman Invented the Modern pH Meter
A 1936 invention by Arnold Beckman that created the first reliable, portable device for measuring the acidity of chemical solutions using electronic sensors.
17 citations
1950s
The Chemical Discovery Behind the First Oral Contraceptive Pill
A 1952 patent for a synthetic hormone that became the active ingredient in the first effective oral contraceptive pill.
19 citations
How Chemical Additives Boost the Effectiveness of Rodent Poisons
A 1953 chemical invention that combines 2-acyl 1,3-indandione with EDTA to create a more effective rodenticide.
4 citations
How the First Heart-Lung Machine Oxygenated Blood
A 1955 invention that allowed surgeons to oxygenate a patient's blood outside the body, enabling the first successful open-heart surgeries.
4 citations
1960s
The First Implantable Cardiac Pacemaker
Wilson Greatbatch's 1960 patent for the first successful implantable heart pacemaker that used a battery to regulate heartbeat.
127 citations
How Dr. Forrest Bird's Mechanical Respirator Controls Patient Breathing
A 1965 patent describing a mechanical ventilator that automatically switches between inhaling and exhaling based on pressure levels in a patient's airway.
78 citations
How Soft Contact Lenses Were Invented Using Hydrogels
This patent describes the chemical recipe for soft, water-absorbing plastic materials that form the basis of modern soft contact lenses.
228 citations
The Discovery of Aspartame as a Sugar Substitute
This 1966 patent identifies specific chemical compounds, known as aspartylphenylalanine esters, that provide intense sweetness for food and drinks without using sugar.
228 citations
1970s
How the First Automatic Implantable Defibrillator Works
A 1970 invention by Medtronic that monitors heart rhythms and automatically delivers an electric shock to restart the heart if it detects a dangerous malfunction.
71 citations
How Early CT Scans Created Detailed Body Images
This 1973 patent describes a method for using X-rays from many angles to build a detailed 2D image of the inside of a body, like a slice of a CT scan.
163 citations
Using Nuclear Magnetic Resonance to Detect Cancer in Tissue
This 1974 patent describes a method and apparatus using nuclear magnetic resonance (NMR) to measure how quickly certain atomic nuclei in a tissue sample return to their normal energy state, helping to distinguish cancerous from healthy tissue.
83 citations
How Scientists Created Bacteria That Eat Oil Spills
A 1981 patent for genetically engineered bacteria capable of breaking down multiple types of oil, which became the first living organism ever patented.
28 citations
Using Radioactive Antibodies to Find Tumors Inside the Body
A 1973 method for finding cancer tumors by injecting patients with radioactive antibodies that attach to tumor-specific proteins, allowing doctors to scan for their location.
66 citations
How Polystyrene Sulfonate Helps Treat Dry Eye Symptoms
A 1975 patent for an eye drop solution that uses a specific polymer to lubricate and cushion the eye, especially for contact lens wearers.
37 citations
How Auto-Injectors Adjust Their Dose Using a Simple Spacer
A 1977 invention for auto-injectors that uses a physical spacer to adjust the amount of medicine inside the device before it is fired.
108 citations
Using Specific Steroid Molecules to Block Salt Retention in the Body
A 1976 medical patent describing the use of 11-beta,18-oxidopregnane compounds to help the body excrete sodium by blocking the salt-retaining effects of the hormone aldosterone.
5 citations
How Early Cochlear Implants Used Digital Signals to Restore Hearing
A 1977 patent describing an electronic device that converts sound into digital pulses to stimulate the auditory nerve, bypassing a damaged inner ear.
55 citations
Chemical Compounds for Fighting Bacterial and Yeast Infections
A 1977 patent for a specific class of amino-phosphonous acid chemicals designed to act as antibiotics against bacteria and yeast.
17 citations
Catheter System for Opening and Closing Body Passages
This 1980 patent describes a medical catheter system with a guide catheter and a special dilatation catheter that can expand to open or close body passages, like blood vessels.
256 citations
How Jarvik's Artificial Heart Uses Electric Motors to Pump Blood
A 1977 invention by Robert Jarvik that uses a reversible electric motor to power a hydraulic pump, enabling artificial hearts to mimic the natural pumping action of a human heart.
68 citations
How to Encapsulate Active Materials in Lipid Bubbles Efficiently
This patent describes a method for trapping biologically active substances inside tiny, multi-layered fat bubbles called liposomes, using a specific water-in-oil emulsion and gel-forming process to improve how much material gets captured.
1,862 citations
How to Detect Disease Markers Using Colored Proteins
A 1981 method for measuring disease-related proteins in blood by attaching them to naturally colored proteins that can be detected with light.
27 citations
How Scientists First Made DNA Replicate in New Cells
This 1980 patent describes a method for cutting and pasting DNA pieces in a lab to create new, self-replicating genetic material that can be inserted into bacteria, a foundational technique for genetic engineering.
346 citations
The Discovery of Lovastatin for Lowering Cholesterol
A 1979 patent by Merck describing the isolation of a fermentation product from Aspergillus fungi that effectively lowers cholesterol levels in the blood.
490 citations
How Scientists Taught Bacteria to Make Human Hormones
Genentech's 1979 patent on using engineered DNA to force bacteria to produce human proteins like insulin and growth hormones.
86 citations
1980s
How Two Special Antibodies Find Substances in Body Fluids
This patent describes a "sandwich" method using two highly specific, man-made antibodies to detect and measure tiny amounts of specific substances, like disease markers, in a fluid sample.
1,572 citations
Boosting Anti-Infective Activity with Muramyldipeptides and Liposomes
This patent describes a method to make anti-infective drugs called muramyldipeptides work better by injecting them separately but close in time with tiny fat bubbles called liposomes into an animal.
2,340 citations
Making Hybrid Antibodies from Different Animals
This patent describes how to create new, engineered antibodies by combining parts of antibodies from two different animal species, then growing them in a lab.
8,214 citations
Mice Engineered to Develop Cancer for Research
Harvard's 1988 patent on genetically engineered mice that carry cancer-causing genes, designed to help scientists study how cancer develops and test treatments.
644 citations
How to Make Human Erythropoietin (EPO) Using Engineered DNA
This patent describes the specific DNA sequences and methods to engineer cells to produce erythropoietin (EPO), a protein vital for red blood cell production, outside the human body.
346 citations
Detecting Genetic Differences Using DNA Probes and Enzymes
This 1987 patent describes a method to find tiny differences in DNA sequences by using special DNA pieces (probes) and cutting enzymes, which can help diagnose genetic conditions like sickle cell anemia.
289 citations
How Special Sugars Make Medicines Dissolve Better
This patent describes how to make poorly water-soluble drugs dissolve and absorb better by mixing them with specially modified, non-crystalline sugar molecules called cyclodextrin derivatives.
341 citations
How Lasers Correct Vision by Reshaping the Eye's Front Surface
This patent describes a method for precisely reshaping the front surface of the eye using an ultraviolet laser to correct vision problems like nearsightedness, farsightedness, and astigmatism.
381 citations
How to Make Many Copies of a Specific DNA Segment
This patent describes the fundamental three-step process for making millions of copies of a specific piece of DNA using short starter molecules and an enzyme, a technique known as Polymerase Chain Reaction (PCR).
7,558 citations
How Doctors Implant a Permanent Stent Using a Balloon
This patent describes the method for placing a permanent, expandable wire mesh tube inside a blood vessel or other body tube using a balloon-tipped catheter to widen it and keep it open.
2,425 citations
How to Make Billions of Copies of a DNA Segment
This patent describes the Polymerase Chain Reaction (PCR), a method to rapidly create many copies of a specific piece of DNA or RNA, enabling its detection and analysis.
6,231 citations
How to Make Many Copies of a DNA Piece with Heat
This patent describes the Polymerase Chain Reaction (PCR) method, a technique to make millions of copies of a specific DNA segment using a heat-resistant enzyme and repeated temperature changes.
2,132 citations
Using Synthetic DNA Fragments to Block HIV Replication
A 1987 patent describing a specific synthetic DNA molecule designed to stop the HIV virus from replicating by blocking a key part of its genetic code.
26 citations
Using Heat-Resistant Enzymes to Read DNA Sequences Faster
This patent describes using a heat-stable enzyme from a bacterium that lives in hot springs to make the process of reading DNA code much more reliable and efficient.
146 citations
How to Make Hard-to-Absorb Medicines Easier for the Body to Use
A method for mixing specific chemical compounds with surfactants to help the body absorb them more effectively.
16 citations
Using PCR to Detect Viruses in Blood and Tissue Samples
A 1989 patent by Nobel laureate Kary Mullis and his team on using polymerase chain reaction (PCR) to replicate and detect tiny amounts of viral DNA or RNA, such as HIV and Hepatitis B, directly from human clinical samples.
122 citations
1990s
How an Enzyme Helps Find Specific DNA in a Sample
This patent describes a method for detecting a specific DNA sequence in a sample by using a labeled DNA probe and an enzyme that cuts the probe, releasing detectable fragments.
1,183 citations
How a Cholesterol-Lowering Drug Molecule Was Patented
This patent protects the specific chemical structure of a molecule designed to lower cholesterol, including its various salt forms and its use in medicine.
519 citations
Preventing Protein Damage with Extra Methionine
This 1993 patent describes how adding extra methionine to protein-based medicines can prevent them from degrading, especially in liquid or semi-solid forms.
63 citations
How to Create Lab-Made Proteins That Stop Immune System Overreaction
A method for creating custom proteins that act as 'brakes' for the body's immune system to prevent damage from excessive inflammation.
27 citations
Using Insect Cells to Create Antibodies for Human Diseases
A method for creating disease-fighting antibodies by using insect cells to display human proteins, which are then injected into animals to trigger an immune response.
25 citations
How to Build Smaller, Synthetic Antibody-Like Molecules for Medicine
This patent describes a way to create small, single-chain proteins that mimic the binding power of full-sized antibodies to deliver medicine more effectively.
440 citations
Using Radioactive Antibodies to Treat B-Cell Lymphoma
A method for treating B-cell lymphoma by using radioactive antibodies to target cancer cells without destroying the patient's bone marrow.
232 citations
How to Measure Gene Activity Using Competitive PCR Kits
A laboratory method and kit for accurately measuring how much a specific gene is being used by cells by comparing it against a known internal standard.
151 citations
New Pyrimidine Chemical Compounds for Treating Tumors
This patent describes specific new chemical compounds, called N-phenyl-2-pyrimidine-amine derivatives, designed with precise molecular structures for potential use in treating cancer.
564 citations
Using Vitamin B12 to Help Proteins Survive the Human Digestive System
A method for attaching therapeutic proteins to Vitamin B12 so they can be absorbed through the gut instead of being injected.
46 citations
How to Redesign Mouse Antibodies for Safe Use in Humans
Genentech's 1995 patent on a systematic method for humanizing rodent antibodies by grafting their disease-targeting loops onto a human consensus framework while carefully swapping key structural support residues to maintain binding strength.
1,161 citations
How Scientists Create Human-Friendly Antibodies for Medicine
This patent describes a method for modifying mouse antibodies so human immune systems accept them as their own, allowing them to be used as powerful, long-lasting medical treatments.
4,274 citations
Antibodies That Block Tumor Necrosis Factor Alpha (TNFα)
This 2000 patent describes specific human antibodies designed to strongly bind and neutralize a protein called TNFα, which is linked to inflammation and autoimmune diseases.
361 citations
Making High-Concentration Antibody Medicines Stable for Injection
Genentech's 2001 patent on a method to create stable, concentrated antibody medicines that can be easily reconstituted for injection, preventing degradation during freezing and storage.
878 citations
How Vaccines Protect Pigs from Respiratory Bacteria
A 1999 patent describing a vaccine for swine that uses specific bacterial proteins to trigger an immune response against the lung disease caused by Actinobacillus pleuropneumoniae.
3 citations
Using Stress Proteins to Help the Body Accept Organ Transplants
A method for preventing organ transplant rejection by using stress proteins to teach the immune system to tolerate donor tissue.
15 citations
How Genentech Created Antibodies to Stop Tumor Growth
A 1997 patent describing a specific humanized antibody designed to block VEGF, a protein that helps tumors grow their own blood supply.
308 citations
Personalized Dosing for Crohn's Disease Drugs Using Blood Tests
A method for adjusting doses of inflammatory bowel disease medication by measuring specific drug metabolites in a patient's red blood cells to maximize effectiveness while avoiding side effects.
75 citations
Using Cannabinoids to Protect the Brain from Oxidative Stress
A government-owned patent describing how certain non-psychoactive cannabinoids can act as antioxidants to protect brain cells from damage caused by strokes, trauma, or diseases like Alzheimer's.
78 citations
How to Use Modified Cells to Produce Insulin-Regulating Proteins in the Body
A method for taking a patient's own cells, modifying them with DNA to produce GLP-1, and putting them back into the body to treat metabolic conditions.
2 citations
How Human Antibodies Block the Immune System's Off-Switch
Abgenix's 1999 patent on fully human monoclonal antibodies that bind to CTLA-4, a protein brake on the immune system, allowing T-cells to stay active and attack cancer cells.
500 citations
2000s
How Genentech Purifies Therapeutic Antibodies for Cancer Treatment
A method for refining mixtures of anti-HER2 antibodies to ensure that harmful acidic variants remain below 25 percent of the total composition.
128 citations
How Genentech Created Antibodies to Target Prostate Cancer Cells
A patent describing specific antibodies that latch onto and kill cancer cells expressing the PSCA protein, effectively turning the body's immune-targeting tools into cancer-fighting weapons.
136 citations
How to Store Fragile Biological Materials Without Refrigeration
A method for preserving unstable biological materials like proteins by trapping them in a solid, glass-like sugar or polymer matrix that prevents decay at room temperature.
11 citations
How to Keep High-Concentration Antibody Medicines Stable in Liquid Form
Novartis's patent describes a specific liquid recipe for keeping high concentrations of E25 anti-IgE antibodies stable and usable for medical injections.
17 citations
How Dosing Humira for Rheumatoid Arthritis Works
This patent defines the specific 40mg biweekly injection schedule for the drug Humira to treat rheumatoid arthritis.
15 citations
How to Take 3D Pictures Inside Human Tissue Using Near-Infrared Light
A system that uses flexible fiber optic cables to map the inside of complex body parts by shining light through them and measuring how it scatters.
25 citations
How Engineered Antibodies Block Inflammation-Causing Proteins
A patent describing lab-made antibodies designed to hunt down and neutralize a specific protein called TNF-alpha that causes chronic inflammation in the body.
77 citations
Using Antibodies to Block HER3 Proteins in Cancer Cells
A patent describing specific antibodies that bind to and block the HER3 protein, which is often used by cancer cells to grow and survive.
5 citations
How Genentech Engineered Antibodies to Starve Tumors of Blood
A 2007 Genentech patent describing specific lab-made antibodies that block a protein called VEGF, which tumors use to grow new blood vessels.
76 citations
Isolating Microbial Proteins That Regulate Cellular Protein Stability
This patent identifies specific genetic sequences from microbes that produce proteins capable of modifying SUMO, a key molecule that controls how other proteins behave inside cells.
6 citations
How Antibodies Can Force Cancer Cells to Self-Destruct
Genentech's patent on specific antibodies that bind to the Apo-2 receptor to trigger programmed cell death in cancer cells.
2 citations
How to Keep Humira Stable in a Liquid Medicine Bottle
A recipe for a stable, liquid version of the drug Humira that stays effective at high concentrations without spoiling or clumping.
58 citations
How Genentech's Antibodies Stop Tumor Blood Vessel Growth
A Genentech patent for specific lab-made antibodies that block a protein called VEGF, effectively starving tumors of the blood supply they need to grow.
54 citations
How Engineered Antibodies Target TGF-beta Proteins to Fight Cancer
This patent describes specific engineered antibodies, made from mouse and human parts, designed to block TGF-beta proteins to help treat various cancers like breast or lung cancer.
756 citations
How Enzymes Help Turn Corn Into Ethanol More Efficiently
A process for making ethanol from starch by using specific enzymes to break down proteins, which helps the fermentation process run more smoothly.
A Gel That Helps Nicotine Absorb Through Your Skin
A specialized gel formula designed to help nicotine pass through the skin or mouth lining without crystallizing or rubbing off on clothes.
25 citations
How Modified RNA Tricks Cells Into Making Proteins Without Triggering Attacks
A breakthrough method for using modified RNA to deliver instructions to cells without causing the body to reject the treatment as a foreign invader.
322 citations
Improving Drug Delivery with Chemical Masks for Thiazolo-Pyrimidine Compounds
A patent describing modified chemical structures that act as dormant precursors, designed to be activated by the body to help treat viral infections like Hepatitis C.
1 citation
How Genentech's Antibody Targets Cancerous B Cells
This patent describes a specific humanized antibody designed to bind to a protein called CD79b, which is found on the surface of certain cancer cells.
13 citations
Using Antibodies to Target Tissue Factor Without Stopping Blood Clotting
A patent describing specific antibodies that attach to a protein called tissue factor without interfering with the body's natural blood-clotting process.
3 citations
How Gilead Made a Stable HIV Pill Combining Two Medicines
This patent describes a stable, single-pill combination of two HIV drugs, tenofovir disoproxil fumarate and emtricitabine, designed to prevent them from breaking down when stored together.
19 citations
Method for Diagnosing Ovarian Cancer Using Biomarkers
This patent describes a method to diagnose ovarian cancer by measuring specific protein levels in a patient's blood sample and comparing them to normal levels.
Using Plant-Derived Chemicals and Metabolic Drugs to Fight Cancer
A medical patent describing a combination therapy that pairs specific plant-derived compounds with metabolic drugs to kill cancer cells more effectively than either could alone.
1 citation
How to Detect Heart Disease in Cats Using Blood Tests
A diagnostic method that uses specific antibodies to measure a protein in cat blood, helping veterinarians identify heart disease.
7 citations
How Specific Antibody Drugs Are Stabilized for Storage and Use
Genentech's 2013 patent details a precise recipe for an antibody drug, like Pertuzumab, using a special buffer, sugar, and cleaning agent to keep it stable for patients.
35 citations
2010s
Using Bacteria to Kill Food-Poisoning Germs on Kitchen Surfaces
A natural cleaning solution using specific bacteria and a protein to stop the growth of dangerous Listeria bacteria on food processing equipment.
1 citation
How a Computer System Automatically Adjusts Blood Sugar in Real-Time
This patent describes a computerized system that continuously monitors a patient's blood glucose and automatically adjusts insulin and dextrose delivery to keep blood sugar levels stable, especially for critically ill patients.
8 citations
How Glucose Sensors Check Their Own Reliability for Insulin Pumps
This patent describes a system that automatically checks how trustworthy a continuous glucose sensor's readings are and then adjusts how an insulin pump delivers medicine based on that trust level.
10 citations
Using Yeast Cell Walls to Deliver Genetic Medicine
A method for using hollowed-out yeast cell walls as tiny transport containers to deliver genetic payloads like DNA or RNA into cells.
4 citations
How Specialized Nanobodies Block Blood Clotting Proteins
A patent describing specific, tiny antibody fragments designed to bind to and inhibit Von Willebrand Factor, a protein that triggers blood clotting.
9 citations
Making Special Materials Inside Commercial Nuclear Power Plants
This patent describes a method for using the neutron radiation inside large commercial nuclear power reactors, specifically in their existing instrumentation tubes, to create useful isotopes like those used in medicine or industry.
5 citations
How Bayer's Engineered Antibodies Help Blood Clotting
This patent describes specific engineered antibodies designed to block a protein that prevents blood clotting, potentially helping people with bleeding disorders.
How Continuous Glucose Monitors Estimate Blood Sugar Levels Accurately
This patent describes a method for accurately estimating blood glucose levels by accounting for the natural delay in glucose moving between interstitial fluid and blood, using sensor data and its rate of change.
9 citations
Making Ivacaftor Easier for the Body to Absorb
A patent describing a specific way to turn a drug molecule into an amorphous solid to help the body absorb it more effectively.
50 citations
How Roche Engineers Antibodies to Target Two Different Diseases Simultaneously
A method for creating a custom-engineered antibody that can grab onto two different targets at once, designed to help the immune system fight complex diseases.
6 citations
Using Dimethyl Fumarate to Treat Multiple Sclerosis
A patent detailing the specific daily dosage of 480mg of dimethyl fumarate for treating multiple sclerosis to protect nerve cells.
52 citations
Using Purified Fish Oil Derivatives to Lower Triglycerides Alongside Statins
A medical treatment method using a specific high-dose, purified EPA supplement to lower triglycerides in patients already taking statin medication.
13 citations
Attaching Flexible Circuits with Light Sensors to a Chip
This patent describes a method and device for attaching a bendable circuit, which includes light-sensing or light-emitting components, onto a main chip, allowing light to pass through a hole in the chip to reach the flexible part.
How Ibrutinib-like Molecules Block Cancer-Causing Proteins
A chemical design for molecules that permanently latch onto and disable a specific protein called Btk, which is often responsible for the growth of certain blood cancers.
33 citations
How Cochlear Implants Use Free-Spinning Magnets to Survive MRI Scans
A cochlear implant design that uses a freely rotating internal magnet to prevent the device from being pulled or damaged by the strong magnetic fields of an MRI machine.
24 citations
Targeted Platinum Drugs for Cancer Treatment
This patent describes a way to deliver platinum-based cancer drugs directly to tumor cells by attaching them to a special 'ligand' molecule that seeks out cancer cell markers.
3 citations
A Custom-Built Protein to Block TGF-beta Signaling in Disease
A laboratory-engineered protein designed to soak up excess TGF-beta molecules, which could help treat conditions like cancer and fibrosis where these signals are overactive.
Chemical Compounds for Treating Hepatitis C Virus
A patent describing specific chemical structures designed to stop the Hepatitis C virus from replicating in humans.
11 citations
How Microbes Turn Carbon Waste into Useful Chemicals
This patent describes a method using special bacteria called oxyhydrogen microorganisms, specifically Rhodococcus sp., to convert carbon dioxide and other single-carbon compounds into valuable organic chemicals like biofuels.
9 citations
How to Edit Genes in Human Cells Using an Engineered CRISPR System
This patent describes an engineered CRISPR-Cas9 system for precisely cutting DNA in eukaryotic cells to change how genes work, opening the door for gene editing in complex organisms.
1,268 citations
Treating Hepatitis C with Combination Drug Therapy
A Gilead Sciences patent detailing a method to treat Hepatitis C by combining a specific chemical compound with an NS5a inhibitor.
42 citations
How to Create Wide-Field Images of Tissue Using OCT Scanners
A method for stitching together multiple high-resolution medical images of uneven tissue samples to create a single, wide-field view for better diagnostic clarity.
9 citations
How Genetically Modified T-Cells Attack Cancer
This patent describes how human T cells are genetically engineered to express a special receptor (CAR) that specifically targets and kills cancer cells, particularly those with the CD19 marker, offering a new way to treat cancer.
65 citations
Gilead's Chemical Compounds for Treating HIV Infections
This patent covers specific chemical structures designed to block HIV from replicating in human cells, providing a foundation for new antiviral medications.
35 citations
Combining Cyclosporine A and Steroids into a Single Hybrid Drug
A chemical method for linking cyclosporine A and steroid molecules into a single hybrid drug designed to treat eye conditions by releasing both components upon contact.
1 citation
How Genentech Engineered Antibodies to Block the Bv8 Protein
This patent details specific genetic blueprints for creating antibodies that target and neutralize Bv8, a protein often associated with tumor growth and inflammation.
Using Genetically Modified Viruses to Target and Treat Cancer
A method for creating a modified vaccinia virus that safely hunts down and kills tumor cells while leaving healthy tissue alone.
15 citations
Headset That Shows Your Brain's Focus Level
A wearable device, like smart glasses, that measures your brain activity to understand your attention or mood, then shows you real-time feedback to help you train yourself.
41 citations
Making Insulin Last Longer with Tiny Coated Drug Particles
This patent describes how to create tiny, layered particles that can hold insulin and release it slowly into the body, aiming for longer-lasting diabetes treatment.
How to Make Stable Solid Dialysis Powder with Less Odor
A specialized solid powder mixture used to create dialysis fluid that stays stable, smells less like vinegar, and keeps acetate levels within a precise, safe range.
New Chemical Compounds for Protecting Crops from Fungal Diseases
A patent describing a specific family of chemical compounds designed to kill or inhibit the growth of fungi that damage agricultural crops.
How Devices Precisely Track Glucose Across Body Compartments
This patent describes a method for accurately estimating a person's blood glucose by accounting for the natural time delay in how glucose moves between different body fluids, like blood and the fluid around cells, to better control insulin pumps.
1 citation
How to Build Tiny Lipid Carriers for Delivering Nutrients
A method for creating tiny, 20-60 nanometer lipid-based particles designed to carry vitamins and nutrients into the human body more effectively.
10 citations
How Gilead Stabilized the HIV Combination Pill Truvada
A patent detailing a stable, fixed-dose combination of two HIV drugs, tenofovir disoproxil fumarate and emtricitabine, designed to prevent chemical breakdown in a single tablet.
Wearable Sensor for Tracking Body Movement and Muscle Activity
This patent describes a wearable device that combines motion sensing with muscle vibration detection to understand how a body moves and which muscles are being used.
2 citations
How to Make Anthrax Vaccines That Survive Freezing
A method for protecting sensitive anthrax vaccines from damage during freezing and thawing by using specific sugars and additives during the drying process.
CRISPR Tools for Engineering Fungal Genomes
This patent describes a specific genetic tool, called an expression vector, designed to efficiently edit the DNA of fungi using the CRISPR-Cas9 system, which is useful for industrial applications like making biofuels or enzymes.
8 citations
How Synthetic Peptides Block Immune System Overreaction
A patent describing specific synthetic peptides designed to stop the body's immune system from attacking healthy cells by blocking a protein called C5.
8 citations
Using the Drug TIC10 to Treat Brain Cancer
A patent for using a specific small molecule drug called TIC10 to treat brain cancers like glioblastoma by triggering a natural cell-death process.
3 citations
How to Design Effective siRNA Molecules to Silence Specific Genes
A patent detailing the precise chemical structure and sequence requirements for siRNA molecules designed to effectively turn off the AAT gene in cells.
3 citations
How Genetically Modified T-Cells Fight CD19 Cancers
This patent describes how to create and use genetically modified human T cells that target and kill cancer cells expressing the CD19 protein, offering a new way to treat blood cancers.
37 citations
How an mRNA Vaccine Targets Prostate Cancer with Six Antigens
This patent describes an mRNA vaccine designed to treat prostate cancer by delivering genetic instructions for a specific combination of six prostate-related proteins, teaching the body to fight the cancer.
84 citations
How an mRNA Vaccine for Lung Cancer Teaches the Immune System to Fight
This patent describes a specific mRNA vaccine designed to treat lung cancer by instructing the body's cells to produce six distinct tumor proteins, thereby training the immune system to recognize and attack cancer cells.
80 citations
Seeing Blood Flow Deep Inside Tissue Without Touching It
This patent describes a way to create 3D images of blood flow up to 1.5 cm deep inside body tissue using near-infrared light, all without any physical contact with the skin.
5 citations
How Sensors Measure Body Joint Movement Across Different Sections
This patent describes a system of bendable and stretchable electromagnetic sensors placed around a body joint in four distinct sections to precisely track its movement.
27 citations
How CRISPR-Cas9 Uses RNA to Edit DNA
This patent describes the fundamental mechanism of using a two-part RNA system to guide the Cas9 protein to specific locations in DNA for precise editing.
49 citations
How to Engineer Antibodies to Better Target and Destroy Disease
This patent describes a way to modify the tail end of an antibody so it binds more strongly to immune cells, helping the body fight off infections or cancer more effectively.
12 citations
Using Antibodies to Block IL-26 for Treating Inflammatory Diseases
A patent for specific antibodies that block the protein IL-26 to help treat inflammatory conditions like psoriasis and Crohn's disease.
1 citation
How to Build Tiny Lipid Capsules to Deliver Genetic Medicines
A precise method for creating small, stable lipid bubbles that safely carry genetic material like siRNA into cells for medical treatment.
10 citations
How Novartis Engineered Antibodies to Block the TIM-3 Immune Checkpoint
A patent describing specific genetic blueprints for antibodies designed to bind to and inhibit the TIM-3 protein, a key target in cancer and immune system research.
10 citations
Using Blood Markers to Diagnose Stroke and Tell Its Type
This patent describes a two-step method for diagnosing a stroke and then determining if it's an ischemic stroke or a transient ischemic attack (TIA) by measuring specific protein levels in a patient's blood.
An Antibody That Detects Specific Sugar-Protein Combinations for Diagnostics
This patent describes a unique antibody designed to precisely recognize a specific sugar-protein structure, particularly a 'fucosylated glycopeptide' found on certain proteins like alpha-fetoprotein (AFP), which is useful for medical tests.
How to Treat Severe Lung Infections Using Ceftolozane and Tazobactam
A medical treatment method for severe, hospital-acquired pneumonia using a specific, recurring intravenous dose of the antibiotic combination ceftolozane and tazobactam.
How to Sequence DNA from Tiny Samples Using Specialized Plates
A method for preparing DNA for genetic sequencing by splitting tiny samples into a 5184-well plate to ensure accurate data from very few cells.
1 citation
How Special Nanoparticles Deliver Cancer Drugs Directly to Tumors
This patent describes tiny fat-based particles, called lipid nanoparticles, designed to carry cancer drugs directly to tumor cells using a special protein (ApoE3) on their surface, avoiding a common, potentially problematic ingredient.
8 citations
Highly Efficient Bacterial Gene Editing Using Guide RNA and Reverse Transcriptase
This patent describes a system for precisely editing the DNA of bacterial cells with very high success rates, using a combination of guide RNA, reverse transcriptase, and specific DNA sequences.
30 citations
Using Antibodies to Protect Transplanted Organs from Damage
A medical method for preserving transplanted organs by using specific antibodies to block a protein that causes inflammation and blood vessel leakage.
How to Use Many CRISPR Guides to Study Many Genes at Once
This patent describes a method to use a large collection of CRISPR-Cas9 guide RNAs to target and modify many different genes or DNA regions across a population of eukaryotic cells, enabling high-throughput genetic screening.
44 citations
How a Special Enzyme Helps Deliver Immune Drugs Under the Skin
This patent describes a specific, modified human hyaluronidase enzyme that helps the body absorb immune globulin drugs when injected just under the skin, making treatments easier for patients.
7 citations
Predicting and Treating Dangerous Side Effects in CAR T-Cell Therapy
This patent describes methods to identify patients at high risk for severe side effects, like cytokine release syndrome or neurotoxicity, during CAR T-cell cancer therapy and how to treat them proactively.
Detecting Alzheimer's Risk Early with a Blood Test and Brain Scan
This patent describes a two-step method to predict early Alzheimer's disease by first checking specific protein levels in a blood sample, and then, if certain markers are low, performing a brain scan to confirm amyloid beta buildup.
Using a Blood Marker to Predict Concussion Risk and Severity
This patent describes a method to diagnose and predict long-term issues from mild traumatic brain injury, like concussions, by measuring a specific protein fragment called SNTF in a blood sample.
1 citation
Targeting Drugs to Specific Body Tissues Using ApoE3-Coated Nanoparticles
This patent describes a method to deliver drugs or diagnostic agents precisely to target cells or tissues, including the brain, by packaging them inside tiny fat particles (lipid nanoparticles) coated with a special protein called ApoE3.
2 citations
Delivering Large Gene Editing Tools into Cells with Hybrid Virus-Lipid Packages
This patent describes a sophisticated delivery system that combines parts of a virus with a fat bubble (liposome) to efficiently transport large molecules, like CRISPR gene-editing components, into specific cells.
A Stable Recipe for a Cancer-Fighting Antibody Drug
This patent describes a specific, stable recipe for a cancer-fighting antibody-drug conjugate (ADC) that targets CD33, using cyclodextrin and a lyoprotectant to keep it effective and reduce impurities.
1 citation
Smart Clothing That Compares Pulse Signals from Both Sides of Your Body
This patent describes a piece of clothing, like a t-shirt, with built-in sensors in its sleeves or legs to measure and compare pulse characteristics from different limbs, helping to detect subtle health differences.
9 citations
How a Specific Protein Fragment Can Train Immune Cells to Fight Cancer
This patent describes methods to fight various cancers by using a specific protein fragment (peptide LYHDIFSRL) to train a patient's immune cells to recognize and attack tumor cells.
4 citations
How a Specific Eye Drop Formula Treats Glaucoma
A patent for a precise, low-concentration eye drop solution designed to lower eye pressure in patients with glaucoma or ocular hypertension.
1 citation
Training Immune Cells to Fight Cancer Using Specific Markers
This patent describes a method to create a powerful immune response against cancer by taking a patient's own T cells, teaching them to recognize specific cancer markers outside the body, and then putting them back to kill cancer cells.
5 citations
How to Design High-Quality Gene Editing Tools for a Whole Genome
This patent describes a computer system and method for creating a comprehensive library of gene-editing guides (sgRNAs) by carefully designing and filtering them to be accurate and avoid unintended genetic changes.
1 citation
CRISPR Gene Editing That Turns Itself Off
This patent describes a CRISPR gene editing system that turns itself off after making a specific genetic change, using a second guide RNA to inactivate the editing enzyme.
Making Drug Proteins Last Longer and Target Diseases Better
This patent describes ways to make protein and peptide drugs stay in the body longer and target specific diseases like autoimmune conditions or cancer more precisely by linking them together or combining them with other molecules.
How Engineered TALE Proteins Can Edit Genes
This patent describes engineered DNA-binding proteins called TALEs, which are shortened and modified to precisely target and edit specific DNA sequences in cells, potentially for gene therapy.
1 citation
Universal Cells to Grow Cancer-Fighting Immune Cells
This patent describes special 'universal' cells called K562 UAPCs that can help grow large numbers of immune cells to fight diseases like cancer.
Training Immune Cells to Fight Specific Cancers
This patent describes a method to treat specific cancers like esophageal or lung cancer by creating specialized immune cells in the lab and giving them to patients to kill cancer cells that display a particular protein fragment.
2 citations
Using Special Mud to Help Plants Grow Better
This patent describes a method using a super-saturated bentonite clay mud mixture to improve plant growth, especially in dry conditions, by retaining more moisture than regular soil.
1 citation
Using mRNA to Teach the Body to Fight Prostate Cancer
This patent describes an active composition, often a vaccine, that uses messenger RNA (mRNA) to instruct a mammal's cells to produce specific prostate cancer proteins, thereby training the immune system to attack prostate cancer cells.
Mapping Tiny Features on a Chip with DNA Barcodes
This patent describes a method for precisely locating individual biological features, like cells or molecules, on a prepared surface by using unique DNA tags and imaging techniques.
Bacteria-Based Vaccines for HIV and Other Infections
This patent describes using specially engineered bacteria, like Salmonella, to create vaccines that teach the body to fight off viruses like HIV by showing it specific parts of the virus on the bacteria's surface.
Using AI to Predict Protein Shapes for Drug Discovery
This patent describes an AI-driven method for iteratively predicting protein 3D structures using a geometry neural network, then using those predictions to find and synthesize new drug molecules.
A Catheter That Measures Glucose While Delivering Medication
This patent describes a medical system that combines a catheter for delivering medication with a continuous glucose sensor built directly onto its surface, allowing for simultaneous monitoring and therapy.
Using Mitochondria to Treat Organ Damage After Blood Flow Problems
This patent describes ways to use isolated mitochondria or special mitochondrial agents to treat or prevent damage to organs that happens when blood flow is cut off and then restored, like during a heart attack or surgery.
Antibodies to Target Tau Protein in Brain Diseases
This patent describes specific antibodies designed to bind to the tau protein, aiming to slow down or stop brain diseases linked to tau, like Alzheimer's.
How Fabric Sensors Measure Pressure on Your Body
This patent describes a flexible, all-fabric sensor that uses special ionic and conducting materials woven into a cloth to detect tiny pressure changes on the body, like blood pulses or movements.
How a Mixed Reality System Helps Plan Orthopedic Surgery
This patent describes a surgical planning system that uses a wearable mixed reality device to project a 3D virtual model of a patient's anatomy directly onto their real body, allowing surgeons to plan procedures without physical markers.
How to Manufacture a Complex Cancer-Fighting Drug Molecule
A detailed chemical recipe for mass-producing a specific cancer-fighting molecule, including the intermediate building blocks needed to construct it efficiently.
2020s
Treating Lysosomal Storage Disease Symptoms with Quinuclidine Compounds
This patent describes methods for using specific quinuclidine compounds, sometimes with enzyme replacement therapy, to treat symptoms like pain and skin issues in patients with lysosomal storage diseases such as Fabry disease.
Diagnosing Brain Conditions by Watching Lab-Grown Neurons Light Up
This patent describes a method to diagnose brain disorders by taking a patient's cell, turning it into a neuron, making it glow when active, and comparing its light patterns to a genetically matched healthy cell.
How Moderna's mRNA Vaccine Technology Targets Betacoronaviruses
A patent describing a specific mRNA vaccine design that uses lipid nanoparticles to deliver genetic instructions for building parts of a betacoronavirus to trigger an immune response.
46 citations
Engineered AAV Vectors for Targeted Gene Delivery to Specific Body Parts
This patent describes specially designed adeno-associated virus (AAV) vectors that can deliver new genetic material to specific tissues in the body, such as the brain, heart, or retina, to treat diseases.
Treating Severe Childhood Epilepsy with Fenfluramine
This patent describes a specific way to treat Lennox-Gastaut Syndrome, a severe form of childhood epilepsy, by giving patients a controlled dose of the drug fenfluramine.
How Automated Microscopes Use Tags to Focus on Biological Samples
A system for automatically focusing and imaging biological samples on a substrate by using special reference marks called tags to guide the microscope's lens.
Checking if Brain Injury Drugs Work Using Saliva or Urine
This patent describes a method to determine if a drug for brain injury is effective by measuring specific sugar molecules in a patient's saliva or urine samples over time.
Making Cancer-Fighting Antibody Drugs Safer with Precise Attachment
This patent describes a specific way to build antibody-drug conjugates (ADCs) for cancer treatment by precisely attaching chemotherapy drugs to antibodies to make them safer inside the body.
How a Catheter Blood Pump Extends Its Tip for Guidance
This patent describes a tiny blood pump on a catheter that can extend a part of its tip forward, guided by a separate internal wire, to help it move safely and precisely inside blood vessels.
Diagnosing Brain Diseases by Measuring a Protein in Blood or Urine
This patent describes a method for diagnosing brain diseases like Alzheimer's and Creutzfeldt-Jakob disease by measuring the amount of a specific protein called beta-synuclein in non-spinal fluid samples such as blood or urine.
2 citations
How Oligonucleotides Target C9orf72 for Brain Diseases
This patent describes using special genetic molecules called oligonucleotides to treat brain diseases like ALS and FTD by targeting a specific gene called C9orf72.
AI Model Predicts Protein Shapes from Infrared Light Data
This patent describes a computer method that uses an artificial intelligence model to predict the detailed 3D shapes of proteins within a food ingredient by analyzing how the ingredient absorbs infrared light.
14 citations
Treating a Specific Lymphoma with Modified T Cells
This patent describes a method to treat a difficult-to-treat type of lymphoma by taking a patient's own immune cells, modifying them to recognize and attack cancer, and then giving them back to the patient.
How to Predict Protein Shapes Better Using Lab Tests and Computers
This patent describes a method to improve predicting a protein's 3D shape by combining computer simulations with actual distance measurements from specific parts of the protein in a lab.
21 citations
Targeting Bad Cells with Toxic Antibodies for Cancer and Autoimmune Disease
This patent describes special antibodies equipped with a toxic payload that specifically seek out and bind to unique markers on diseased cells, like cancer or autoimmune cells, to destroy them.
Improving How Blood Platelets Are Stored
This patent describes new chemical compounds and methods to prevent damage to blood platelets when they are stored, like in blood banks, making them last longer and more effective for transfusions.
Targeted Cancer Drugs Using Antibodies and Polymer Scaffolds
This patent describes a new way to deliver powerful cancer drugs directly to tumor cells using a specific antibody attached to a special polymer, aiming to reduce side effects.
3 citations
A Medical Guidewire That Bends to Protect Tissue
This patent describes a medical guidewire assembly designed to safely puncture a body wall, featuring a flexible tip that automatically forms a protective shape once it exits a guiding tube, preventing the sharp piercing tool from accidentally harming nearby healthy tissue.
Predicting How Molecules Interact with Proteins Using Two AI Streams
This patent describes a computer system that uses two separate artificial intelligence models, one for molecules and one for proteins, to predict how they will interact and what biological effects they might have.
7 citations
New Nanoparticles for Delivering Large RNA Medicines to Cells
This patent describes a specific type of modified dendrimer nanoparticle designed to efficiently deliver large RNA molecules, like replicating RNA, into cells for therapeutic, prophylactic, or diagnostic purposes, notably without using cholesterol.
Boosting Plant Gene Editing and Regeneration with Special Genes
This patent describes a method to make plant genetic engineering more efficient by adding specific genes that encourage plant cells to divide and grow, making it easier to create new plants with desired traits.
1 citation
How Tiny Particles Make CBD Easier to Absorb
This patent describes a special mix of ingredients that creates tiny, stable CBD particles, making it easier for the body to absorb the compound and improving how long it lasts in the body.
2 citations
A New, More Accurate Test for 'Walking Pneumonia' Bacteria
This patent describes a new method and instrument for detecting *Mycoplasma pneumoniae*, the bacteria causing 'walking pneumonia,' using a special antibody that binds strongly to two specific proteins from the germ.
How to Make Animals That Can Turn On CRISPR Gene Editing
This patent describes creating genetically modified non-human animals, like mice, where a key CRISPR gene-editing protein (Cas9) can be turned on only in specific cells or at specific times using a special genetic switch.
Combining Abiraterone, Niraparib, and Prednisone for Prostate Cancer Treatment
This patent describes a new way to treat prostate cancer by combining three specific medications: abiraterone acetate, niraparib, and prednisone.
Computer Model Designs Proteins by Matching Structure to Sequence
IBM's 2025 patent describes a computer system that designs new protein sequences by first understanding a target 3D protein shape and then generating a sequence that would fold into that shape.
How Computers Predict Protein Shapes Faster Using Smart Templates
This patent describes a computer method to quickly predict the 3D shape of proteins by creating and refining "synthetic templates" from existing protein structures, reducing the heavy computational work usually needed.
1 citation
How a Specific Peptide Boosts the Immune System Against Cancer
This patent describes a specific peptide sequence, KESDGFHRF, combined with immune-boosting substances and a safe delivery method, for use in treating cancer through immunotherapy.
1 citation
Antibodies that Deliver Drugs to Cells Using Transferrin Receptors
This patent describes special antibodies that bind to transferrin receptors on cells to deliver molecular payloads, such as genetic material, for therapeutic purposes.
Using Two Specific RNAs to Teach the Body to Fight Lung Cancer
This patent describes an active composition containing two specific messenger RNAs, NY-ESO-1 and MAGE-A3, designed to stimulate an immune response in a mammal to treat lung cancer, especially non-small cell lung cancers.
7 citations
Using Specific Immune Cells to Fight Cancers Like Lung and Breast Cancer
This patent describes a method to treat specific cancers, including lung, breast, and ovarian cancer, by giving patients their own immune cells (T cells) that have been trained to recognize and destroy cancer cells presenting a unique protein fragment.
8 citations
Making and Separating Specific Chemical Forms of a Drug Compound
This patent describes a method to convert a specific chemical compound into a balanced mixture of its mirror-image forms and then separate one desired form, important for making medicines.
Making Deuterium-Labeled Chemicals Precisely with Metal Catalysts
This patent describes new ways to precisely add a special type of hydrogen called deuterium to specific parts of chemical molecules using metal helpers, making them useful for medicines or research.
Device for Collecting and Separating Bodily Fluids Using Pressure
This patent describes a device that uses different levels of negative pressure to first isolate a portion of bodily fluid and then collect a separate sample from a fluid source.
Chemical Compounds to Block a Specific KRAS Cancer Gene
This patent describes new chemical compounds designed to stop a specific mutated protein called KRAS G12C, which is often found in various cancers, potentially offering new ways to treat the disease.
Improving AI Predictions by Factoring in How Much You Trust Each Model
This patent describes a method for making an AI system more accurate by combining several individual AI models and giving more weight to the ones considered more trustworthy.
31 citations
Tiny Epinephrine Particles for Fast-Dissolving Under-Tongue Tablets
This patent describes new compositions of extremely small epinephrine particles designed for fast-dissolving tablets that are absorbed under the tongue, aiming to treat severe allergic reactions or cardiac events more effectively with a lower dose.
How Suction Controls Fluid Collection for Medical Tests
This patent describes a device that uses different levels of suction to precisely control and separate bodily fluids, like blood, for collection and analysis.
How Computers Use Brain Maps to Diagnose Alzheimer's Disease
A method for classifying stages of Alzheimer's disease by turning brain scan data into mathematical graphs and using machine learning to identify patterns.
Wearable Wrap Detects Blood Clots and Swelling in Joints
This patent describes a smart wrap for joints like knees or elbows that uses temperature sensors to spot early signs of dangerous blood clots and stretch sensors to detect swelling during recovery.
Using Antibodies and CAR-T Cells to Fight MUC1-C Expressing Cancers
This patent describes specific antibodies and engineered immune cells (CAR-T) designed to target and treat cancers that produce a particular protein called MUC1-C.
Boosting Plant Health with Beneficial Microbes Inside Plants
This patent describes ways to improve plant health by introducing helpful microorganisms, called endophytes, into plants or their parts.
How an mRNA Vaccine Teaches Your Body to Fight Rabies
This patent describes a method for creating an immune response against the rabies virus by injecting a specific messenger RNA molecule that instructs cells to produce a key rabies protein.
How Modified IL2 Proteins Can Treat Human Diseases
This patent describes new versions of the human immune protein Interleukin-2 (IL2), called muteins, designed to specifically target certain immune responses for treating various human diseases.
Tiny Lipid Balls for Precise, Better-Absorbed Cannabinoid Medicine
This patent describes a drug delivery system using tiny lipid nanoparticles to encapsulate cannabinoids, making them easier for the body to absorb and allowing for precise, smaller doses.
Targeting Liver and Bile Duct Cancers with Specific Immune Cells
This patent describes a method to treat liver and bile duct cancers by using specially activated immune cells that recognize a unique protein fragment found on these cancer cells.
How to Amplify Many DNA Targets at Once, Cleanly
This patent describes methods for simultaneously making many copies of different DNA sections in a single test tube, along with ways to choose the right starting pieces (primers) to avoid unwanted byproducts.
Better Lab Tests with Engineered Humanized Antibodies
This patent describes a special lab test ingredient, a 'humanized antibody,' designed to make medical and research tests more accurate by preventing false alarms.
Precise Medicine Delivery Device with Priming Control
This patent describes a device for accurately measuring and delivering liquid medicine, using a special mechanism to control how a plunger moves during both initial setup and actual delivery.
How to Make Long-Lasting Injections for Multiple Sclerosis Treatment
A patent for a slow-release version of the MS drug glatiramer acetate, designed to be injected once every week to six months instead of daily.
How to Transfer Sleep Brain Patterns Between People
This patent describes a futuristic method for taking the brain activity patterns of a sleeping person and inducing those same patterns in another person to make them sleep.
How to Adjust Specific Parts of an Ultrasound Image
This patent describes a system that lets doctors brighten or change specific small areas within an ultrasound scan independently, without affecting the rest of the image.
How Circular Probes Find Specific DNA in Cells
This patent describes a method using special circular DNA probes and enzymes to precisely detect specific genetic sequences within a cell or tissue sample, then amplifies the detected sequences for clear viewing.
Treating Muscular Dystrophy with a Self-Complementary AAV Gene Therapy
This patent describes a method to treat muscular dystrophy by delivering a specific gene using a specially designed, self-complementary adeno-associated virus (AAV) vector.
Making Antibody Drug Conjugate Medicines Consistent Across Batches
This patent describes methods for precisely controlling the drug amount in antibody drug conjugate (ADC) medicines, ensuring each batch has a consistent strength and effect.
How Antibodies Block VLA-4 to Treat Inflammatory Diseases
This patent describes antibodies, which are immune system proteins, designed to specifically attach to and block a target protein called VLA-4, which is involved in inflammation and immune responses.
Adjusting Eye Implants with Lasers for Clearer Vision
This patent describes using precise laser pulses to change the focusing power of an implanted artificial eye lens, helping people see clearly without glasses.
How a Sensor Checks Itself for Accuracy Using Other Body Data
This patent describes a smart system that uses additional body measurements or relationships between different body chemicals to figure out if an analyte sensor, like a glucose monitor, is giving wrong readings and then fixes it or tells you to replace it.
7 citations
How to Find Antibodies That Only Detect Bound Drug Targets
This patent describes a method to create and use special antibodies that only detect when a therapeutic or diagnostic antibody is bound to its target, ignoring both the target and the unbound antibody.
Training AI on Private Data Without Seeing It
This patent describes a way to train artificial intelligence models using private data stored on many separate computers, by generating fake data that mimics the real data's patterns, so the private data itself never leaves its original location.
New Peptide Vaccines for Fighting Cancer
This patent describes new protein fragments, called polypeptides, designed to help the body's immune system fight specific cancers like lung, stomach, and skin cancer.
Making Strong, X-Ray Visible Cobalt Alloys for Medical Implants
This patent describes a specific heat treatment process to remove unwanted particles from cobalt-based alloys, making them strong and visible on X-rays for use in medical implants like stents.
How Special Molecules Boost Cancer-Fighting CAR-T Cells
This patent describes special molecules made of a CAR-T cell activator attached to a fat-like part, designed to make cancer-fighting CAR-T cells grow and work better inside a patient.
2 citations
A New Heart Valve That Replaces Old Ones Without Open Surgery
This patent describes a prosthetic heart valve that can be inserted without major surgery, using an expandable support and special arms to hold it in place within the heart.
Blocking RUNX1 to Stop Eye Scarring and Cell Changes
This patent describes using methods and substances to stop certain cells in the eye from growing too much or changing their type, which can cause serious eye conditions like scarring.
How to Precisely Edit Genes Using Retron-Guide RNA Cassettes
This patent describes a method for highly efficient and precise genome editing using a retron-guide RNA cassette to deliver large pieces of donor DNA into a cell's genetic material.
Augmented Reality Glasses for Guiding Surgeons
This patent describes a head-mounted augmented reality display, like smart glasses, specifically designed to help surgeons by overlaying digital patient data and markers directly onto their view of the patient during medical procedures.
14 citations
Treating Liver Cancer with Specially Trained Immune Cells
This patent describes a method for treating hepatocellular cancer by giving patients specially activated immune cells that are trained to recognize and kill cancer cells displaying a specific protein fragment.
Targeting Cancer with CAR T Cells Using a Chemical Tag
This patent describes a method to treat cancer by giving a patient special immune cells (CAR T cells) that recognize a chemical tag, which is attached to a small drug molecule, along with a separate folate compound.
1 citation
A Biopsy Cap with Helical Brushes for Endoscopes
This patent describes a specialized cap for endoscopes that uses brushes arranged in a spiral pattern to collect tissue samples during medical procedures.
Removing Blood Clots from Brain Vessels with a Special Catheter
This patent describes a specialized catheter system designed to quickly remove blood clots from tiny blood vessels in the brain, often used to treat strokes, by using suction.
Ensifentrine Drug for Reducing COPD Flare-Ups
This patent describes using the drug ensifentrine to reduce how often and how severe flare-ups of chronic obstructive pulmonary disease (COPD) are in patients.
How to Make Very Pure Phentolamine Mesylate for Medicine
This patent describes a specific chemical recipe using acetone and water to create a very pure version of phentolamine mesylate, a drug used in medicine.
How Quantum Computers Learn to Sort Data
This patent describes a method for training a data classifier using a quantum computer, where classical AI helps prepare the data and interpret the quantum results to improve the quantum system's ability to sort information.
AI Predicts Prostate Cancer Spread from Medical Scans
This patent describes how artificial intelligence can analyze medical scans of a prostate tumor to automatically identify suspect regions and predict if the cancer will spread to other parts of the body.
How a Wearable Device Measures Heart Rate and Blood Flow with Lasers
This patent describes a wearable device that uses a single laser and two different optical sensors—an image sensor and a photodiode—to measure both blood flow patterns (SPG) and blood volume changes (PPG) from biological tissue.
Draining Brain Fluid into Neck Veins to Treat Hydrocephalus
This patent describes a medical device, a shunt, designed to drain excess fluid from the brain into a specific neck vein to treat a condition called hydrocephalus, using a controlled flow rate.
A Four-Legged Staple for Fixing Broken Fibula Bones
This patent describes a special four-legged staple designed to fix broken bones, especially the fibula, by using its spring-like action to pull bone pieces together with forces in multiple directions.
How to Calibrate Health Measurements Using Related Body Data
This patent describes a way to make health measurements more accurate by adjusting them based on other related body data, needing less testing and computer power.
How Radio Waves Measure Heart Movement and Fluid in the Chest
This patent describes a diagnostic system that uses multiple radio frequency antennas placed on the chest to send waves towards the heart, then analyzes the scattered signals to measure the heart's movement in detail.
How to Connect Wires and Light Signals Through a Protective Cloth
This patent describes a system to make both electrical and optical connections by pushing a plug into a socket, with a protective cloth or 'drape' placed in between, where a sharp part on the plug pokes through the drape.
A Tiny Blood Pump That Minimizes Damage to Blood Cells
This patent describes a small, tube-shaped blood pump designed to fit inside a blood vessel, using a spinning fan to move blood without blocking flow and with special features to prevent damage to red blood cells.
A Special Sticky Layer for Tiny Liquid Channels in Flow Cells
This patent describes a specific middle layer, called an interposer, for devices that handle tiny amounts of liquid (flow cells), featuring a black plastic base and two methyl acrylic adhesive layers, all pierced by microfluidic channels.
How to Copy Many DNA Sections at the Same Time
This patent describes methods for simultaneously copying multiple specific DNA or RNA segments in a single test tube, along with strategies for selecting the short DNA starter pieces (primers) to ensure accurate and efficient amplification.
AI Predicts 3D Protein Shapes from Genetic Code
This patent describes how a computer uses self-attention neural networks to predict the complex three-dimensional shape of a protein based on its simple amino acid sequence, a process crucial for understanding biology and developing new medicines.
Targeting Cancer with CAR T Cells Using Small Molecule 'Flags'
This patent describes a method to treat cancer by giving a patient special immune cells (CAR T cells) that are trained to find a specific 'flag' molecule, and then also giving them a drug molecule attached to that same 'flag' in varying amounts or forms.
How a Droplet Device Delivers Medicine When You Breathe In
This patent describes an electronic device that sprays a fine mist of liquid, like medicine, into your mouth or nose automatically when it detects you are inhaling at a specific speed.
Tracking Plant Microbes with Their Natural DNA Barcodes
This patent describes a method to track how microbes colonize plant roots by using and reconfiguring their naturally occurring DNA sequences as unique tags.
Treating Lewy Body Dementia by Targeting Patients Without Tau Protein
This patent describes a method to treat a specific type of Dementia with Lewy Bodies in patients who don't have a lot of another brain protein called tau, using a special kind of drug.
Finding Rare Genetic Changes in Blood Using DNA Fragments
This patent describes a system and method for detecting uncommon genetic mutations and changes in gene copy numbers from DNA fragments found freely in bodily fluids, like blood.
AI System for Analyzing Medical Images Using Magnification-Aligned Transformers
This 2025 patent describes an AI system that analyzes medical images, like those from pathology slides, by using a special 'Transformer' model that understands how image details change with magnification.
New HPBCD Mixtures for Treating Niemann-Pick Disease Type C
This patent describes specific mixtures of a modified sugar molecule, hydroxypropyl beta-cyclodextrin, designed for direct delivery to the brain to treat the rare genetic disorder Niemann-Pick disease Type C.
Treating Niemann-Pick Type C with a Special Sugar Mixture
This patent describes specific mixtures of modified beta-cyclodextrin molecules designed for direct delivery to the brain to treat the rare genetic disorder Niemann-Pick disease Type C.
Easier Injections for Multiple Myeloma Cancer Treatment
This patent describes specific liquid mixtures (formulations) of anti-CD38 antibodies designed to be injected just under the skin for treating multiple myeloma, making administration simpler than traditional intravenous methods.
How a Surgical Device Temporarily Anchors in the Intestine
This patent describes a surgical device designed to temporarily attach itself to the inner wall of the intestine using a controllable suction mechanism and a radially elastic wall.
Custom Spinal Fusion Devices with Built-in Anchors
This patent describes custom-made spinal fusion devices designed for a specific patient, featuring an implant placed between vertebrae and special ways to hold its anchoring parts in place.
How to Make Amphetamine Tablets Last Longer in Your Body
This patent describes a specific type of extended-release amphetamine tablet that combines different forms of amphetamine and special coatings to provide a therapeutic effect for at least thirteen hours after a single dose.
Moving Chemical Ingredients Between Tiny Liquid Drops
This patent describes a method for precisely transferring a chemical ingredient from one tiny liquid droplet to another, changing the concentration of that ingredient in both drops.