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How to Build Tiny Lipid Carriers for Delivering Nutrients

A method for creating tiny, 20-60 nanometer lipid-based particles designed to carry vitamins and nutrients into the human body more effectively.

Granted 2018ActiveExpires 2034Owned by Nanosphere Health SciencesInvented by Richard Clark Kaufman

Original patent title: “Nanoparticle compositions and methods as carriers of nutraceutical factors across cell membranes and biological barriers

Plain-English explanation by SahiLast reviewed · July 6, 2026

A method for creating tiny, 20-60 nanometer lipid-based particles designed to carry vitamins and nutrients into the human body more effectively. Granted to Nanosphere Health Sciences in 2018 with 6 claims and 10 forward citations, and it is expected to expire in 2034.

Coverage

What does this patent actually cover?

This patent describes a specific manufacturing process to create lipid structural nanoparticles, which act as tiny delivery vehicles. The method requires combining essential phospholipids and fatty acids using at least three distinct production techniques, such as high-pressure homogenization and ultrasonication. By using these specific combinations, the process creates particles between 20 and 60 nanometers in size. These particles are then loaded with nutraceuticals or vitamins to help them cross biological barriers in mammals.

The gap

What does this patent NOT cover?

  • Does not cover delivery systems larger than 60 nanometers.
  • Does not cover methods using fewer than three of the listed production techniques.
  • Does not cover the chemical composition of the nutraceuticals themselves, only the carrier system.
  • Does not cover non-lipid based nanoparticle delivery vehicles.

These exclusions are unique to PatentBrief — derived from the actual claim language, not patent-office boilerplate.

Key facts

Patent numberUS 9925149
StatusActive
FieldBiotech & Medicine
AssigneeNanosphere Health Sciences
InventorRichard Clark Kaufman
Filed2014
Granted2018
Expires2034
Claims6
Times cited10
LitigationNone on record
Value · $144K$461KModest

What made this novel

The innovation lies in the mandatory use of a triple-process manufacturing sequence, which ensures the resulting lipid particles are consistently small enough (20-60nm) to effectively penetrate biological membranes.

Nanoparticle compositions and …(Primary claim)biotechpharmaceutical

Schematic visualization of the patent's claim structure. Hand-drawn diagrams in progress for each landmark patent.

Where you've seen this

Real-world examples

01

Liposomal vitamin C supplements

02

Nano-encapsulated nutraceutical powders

03

Enhanced absorption dietary supplements

Why it matters

The bigger picture

Improving the bioavailability of nutrients is a major goal in the health and wellness industry. By creating a standardized way to package supplements into tiny lipid spheres, this technology aims to ensure that vitamins and other compounds are better absorbed by the body rather than being broken down prematurely.

Filed

October 14, 2014

Granted

March 27, 2018

Market context

Who's building on this

Companies in this space

Nanosphere Health Sciences, the original assigneeassigneeThe entity that owns the patent — usually the inventor's employer or a company.Read more →, has focused on applying this technology to various supplement delivery platforms. Other companies in the liposomal delivery space continue to refine these manufacturing techniques to improve the stability and absorption rates of oral supplements.

Market impact

This patent provides a specific technical framework for manufacturers of high-end nutraceuticals to claimclaimA numbered sentence at the end of a patent that legally defines what the inventor owns. The most important section.Read more → improved delivery performance. It helps differentiate premium supplement products that utilize advanced nanotechnology from standard, less bioavailable formulations.

Claim 1 — Plain English

What this patent covers

This patent describes a specific manufacturing process to create lipid structural nanoparticles, which act as tiny delivery vehicles. The method requires combining essential phospholipids and fatty acids using at least three distinct production techniques, such as high-pressure homogenization and ultrasonication. By using these specific combinations, the process creates particles between 20 and 60 nanometers in size. These particles are then loaded with nutraceuticals or vitamins to help them cross biological barriers in mammals.

The clever bit

The innovation lies in the mandatory use of a triple-process manufacturing sequence, which ensures the resulting lipid particles are consistently small enough (20-60nm) to effectively penetrate biological membranes.

What it does not cover

  • Does not cover delivery systems larger than 60 nanometers.
  • Does not cover methods using fewer than three of the listed production techniques.
  • Does not cover the chemical composition of the nutraceuticals themselves, only the carrier system.
  • Does not cover non-lipid based nanoparticle delivery vehicles.

Patent timeline

Filing

Application submitted to the patent office

Publication

Application published, typically 18 months after filing

Grant

Patent officially issued

Expiration

Patent enters public domain

PatentBrief Score

Impact Score

Early stage

Citation count

21/40

Early citations

Claim breadth

4/20

Moderate scope

Recency

10/20

Granted 5–10 years ago

Assignee scale

0/20

Independent or smaller assigneeassigneeThe entity that owns the patent — usually the inventor's employer or a company.Read more →

PatentBrief Impact Score — based on citation count, claim breadth, recency, and assignee scale. Not a legal assessment.

Heuristic Value Estimate

What this patent might be worth

Modest

$144K$461K

Midpoint $288K · 8.3 yr remaining · industry ×3.0

Adjust inputs →

Heuristic only — blends forward/backward citation counts, claim scope, time remaining, litigation history, and CPC-derived industry baseline. Real valuations need a professional appraisal.

Claim text not yet imported for this patent

The original legal language

Original claims

6 claims as filed with the patent office.

Concepts involved

ClaimPrior artNon-obviousnessNoveltySpecificationAssigneePatent term

Citations

Patent lineage

Cites earlier patents

20

earlier patents this invention cites as foundations

View prior art →

Cited by later patents

10

later patents that build on this invention

View patents →

Cite this patent

Kaufman, R. C. (2018). How to Build Tiny Lipid Carriers for Delivering Nutrients (U.S. Patent No. 9,925,149). U.S. Patent and Trademark Office. https://patentbrief.org/patent/us/9925149/nanoparticle-compositions-and-methods-as-carriers-of-nutraceutical-factors-acros

Auto-generated from the patent record. Double-check author order and the issue date against the official USPTO document before submitting.

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Common Questions

Frequently Asked Questions

What does How to Build Tiny Lipid Carriers for Delivering Nutrients cover?

A method for creating tiny, 20-60 nanometer lipid-based particles designed to carry vitamins and nutrients into the human body more effectively.

Who owns patent US 9925149?

Nanosphere Health Sciences owns this patent, granted in 2018.

When does this patent expire?

This patent is expected to expire on October 14, 2034, when the invention enters the public domain.

What is patent US 9925149 cited by?

This patent has been cited by 10 later patents that build on its ideas.

What problem does this patent solve?

Improving the bioavailability of nutrients is a major goal in the health and wellness industry. By creating a standardized way to package supplements into tiny lipid spheres, this technology aims to ensure that vitamins and other compounds are better absorbed by the body rather than being broken down prematurely.

What does this patent NOT cover?

Does not cover delivery systems larger than 60 nanometers.

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Last reviewed: July 6, 2026 · PatentBrief is not a law firm and this is not legal advice.