PatentBrief

Cannabinoids as antioxidants and neuroprotectants

Cannabinoids have been found to have antioxidant properties, unrelated to NMDA receptor antagonism. This new found property makes cannabinoids useful in the treatment and prophylaxis of wide variety of oxidation associat…

Granted 2003activeExpired 2019Owned by US Department of Health and Human ServicesInvented by Aidan J. Hampson, Julius Axelrod, Maurizio Grimaldi

Original patent title: “Cannabinoids as antioxidants and neuroprotectants

What this patent covers

The actual claim

Cannabinoids have been found to have antioxidant properties, unrelated to NMDA receptor antagonism. This new found property makes cannabinoids useful in the treatment and prophylaxis of wide variety of oxidation associated diseases, such as ischemic, age-related, inflammatory and autoimmune diseases. The cannabinoids are found to have particular application as neuroprotectants, for example in limiting neurological damage following ischemic insults, such as stroke and trauma, or in the treatment of neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease and HIV dementia. Nonpsychoactive cannabinoids, such as cannabidoil, are particularly advantageous to use because they avoid toxicity that is encountered with psychoactive cannabinoids at high doses useful in the method of the present invention. A particular disclosed class of cannabinoids useful as neuroprotective antioxidants is formula (I) wherein the R group is independently selected from the group consisting of H, CH3, and COCH3.

What this patent does NOT cover

The boundaries

    These exclusions are unique to PatentBrief — derived from the actual claim language, not patent-office boilerplate.

    Cannabinoids as antioxidants a…(Primary claim)

    Schematic visualization of the patent's claim structure. Hand-drawn diagrams in progress for each landmark patent.

    Patent Abstract

    Patent abstract

    Cannabinoids have been found to have antioxidant properties, unrelated to NMDA receptor antagonism. This new found property makes cannabinoids useful in the treatment and prophylaxis of wide variety of oxidation associated diseases, such as ischemic, age-related, inflammatory and autoimmune diseases. The cannabinoids are found to have particular application as neuroprotectants, for example in limiting neurological damage following ischemic insults, such as stroke and trauma, or in the treatment of neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease and HIV dementia. Nonpsychoactive cannabinoids, such as cannabidoil, are particularly advantageous to use because they avoid toxicity that is encountered with psychoactive cannabinoids at high doses useful in the method of the present invention. A particular disclosed class of cannabinoids useful as neuroprotective antioxidants is formula (I) wherein the R group is independently selected from the group consisting of H, CH3, and COCH3.

    Patent Journey

    From filing to expiry

    Patent Filed

    1999

    Patent Granted

    2003 · 4yr after filing

    Highly Cited

    78 patents cite this

    Patent Expired

    2019

    PatentBrief Score

    Impact Score

    57/ 100

    Moderate

    Citation count

    38/40

    Highly cited

    Claim breadth

    19/20

    Very broad protection

    Recency

    0/20

    Older than 20 years

    Assignee scale

    0/20

    Independent or smaller assignee

    PatentBrief Impact Score — based on citation count, claim breadth, recency, and assignee scale. Not a legal assessment.

    The original legal language

    Original claims

    29 claims as filed with the patent office.

    Citations

    Patent lineage

    Cites earlier patents

    22

    earlier patents this invention cites as foundations

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    Cited by later patents

    78

    later patents that build on this invention

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