Method of producing lipid nanoparticles for drug delivery
What is described is a method for preparing a liposome that efficiently encapsulates a negatively charged therapeutic polymer, e.g., siRNA. The process involves preparing a lipid mixture comprising a cationic lipid in a …
Original patent title: “Method of producing lipid nanoparticles for drug delivery”
What this patent covers
The actual claim
What is described is a method for preparing a liposome that efficiently encapsulates a negatively charged therapeutic polymer, e.g., siRNA. The process involves preparing a lipid mixture comprising a cationic lipid in a water miscible organic solvent, such as ethanol, at a concentration of 2.3 mg/ml, and adding this solution to the polymer dissolved in water to a final concentration of 35% ethanol in water. The final charge ratio of drug:lipid is 1:2.5. The resulting nanoparticles have a mean size of 50 to 150 nm.
What this patent does NOT cover
The boundaries
These exclusions are unique to PatentBrief — derived from the actual claim language, not patent-office boilerplate.
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Patent Abstract
Patent abstract
What is described is a method for preparing a liposome that efficiently encapsulates a negatively charged therapeutic polymer, e.g., siRNA. The process involves preparing a lipid mixture comprising a cationic lipid in a water miscible organic solvent, such as ethanol, at a concentration of 2.3 mg/ml, and adding this solution to the polymer dissolved in water to a final concentration of 35% ethanol in water. The final charge ratio of drug:lipid is 1:2.5. The resulting nanoparticles have a mean size of 50 to 150 nm.
Patent Journey
From filing to today
Patent Filed
2017
Patent Granted
2018 · 2yr after filing
Active Today
2026
Expires
2037
PatentBrief Score
Impact Score
Moderate
Citation count
21/40
Early citations
Claim breadth
16/20
Broad claims
Recency
10/20
Granted 5–10 years ago
Assignee scale
0/20
Independent or smaller assignee
PatentBrief Impact Score — based on citation count, claim breadth, recency, and assignee scale. Not a legal assessment.
The original legal language
Original claims
24 claims as filed with the patent office.
Citations
Patent lineage
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