US 4683195 · 1987exp. 2006
How to Make Billions of Copies of a DNA Segment
This patent describes the Polymerase Chain Reaction (PCR), a method to rapidly create many copies of a specific piece of DNA or RNA, enabling its detection and analysis.
Cetus Corp6231 citations
biotechpharmaceuticaldiagnostics
US 7657849 · 2010exp. 2025
How the iPhone's Slide-to-Unlock Gesture Works
Apple's 2010 patent describes unlocking a device by dragging a specific graphical image across the touchscreen along a predefined path, a gesture that became iconic with the original iPhone.
Apple Inc1269 citations
consumer_electronicssoftwaretelecommunications
US 4733665 · 1988exp. 2005
How Doctors Implant a Permanent Stent Using a Balloon
This patent describes the method for placing a permanent, expandable wire mesh tube inside a blood vessel or other body tube using a balloon-tipped catheter to widen it and keep it open.
Expandable Grafts Partnership2425 citations
medical_devicescardiovascularbiotech
US 4965188 · 1990exp. 2007
How to Make Many Copies of a DNA Piece with Heat
This patent describes the Polymerase Chain Reaction (PCR) method, a technique to make millions of copies of a specific DNA segment using a heat-resistant enzyme and repeated temperature changes.
Cetus Corp2132 citations
biotechpharmaceuticalsdiagnostics
US 4235871 · 1980exp. 1998
How to Encapsulate Active Materials in Lipid Bubbles Efficiently
This patent describes a method for trapping biologically active substances inside tiny, multi-layered fat bubbles called liposomes, using a specific water-in-oil emulsion and gel-forming process to improve how much material gets captured.
1862 citations
biotechpharmaceuticalmaterials
US 4405829 · 1983exp. 1997
How RSA Public-Key Encryption Keeps Digital Messages Secret
This patent describes the foundational RSA algorithm, a method for securely sending messages where anyone can encrypt a message using a public key, but only the intended recipient can decrypt it using a secret private key.
Massachusetts Institute of Technology1015 citations
softwaretelecommunicationscybersecurity
US 4575330 · 1986exp. 2004
How 3D Printers Build Objects Layer by Layer from Liquid
This patent describes the foundational method for 3D printing, where a machine builds a three-dimensional object layer by layer by hardening a liquid material with light or other energy.
UVP Inc1094 citations
manufacturingmechanicalmaterials
US 4683202 · 1987exp. 2005
How to Make Many Copies of a Specific DNA Segment
This patent describes the fundamental three-step process for making millions of copies of a specific piece of DNA using short starter molecules and an enzyme, a technique known as Polymerase Chain Reaction (PCR).
Cetus Corp7558 citations
biotechpharmaceuticaldiagnostics
US 4376110 · 1983exp. 2000
How Two Special Antibodies Find Substances in Body Fluids
This patent describes a "sandwich" method using two highly specific, man-made antibodies to detect and measure tiny amounts of specific substances, like disease markers, in a fluid sample.
Hybritech Inc1572 citations
biotechpharmaceuticaldiagnostics
US 3953566 · 1976exp. 1993
Making Strong, Porous PTFE: The Gore-Tex Process
This patent describes a specific process for rapidly stretching a highly crystalline form of PTFE plastic to create a strong, porous material with a unique internal structure, forming the basis for products like Gore-Tex.
WL Gore and Associates Inc1364 citations
materialsconsumer_electronicsautomotive
US 5121329 · 1992exp. 2009
How Machines Build 3D Objects Layer by Layer from Melting Plastic
This patent describes a method and machine for creating three-dimensional objects by precisely depositing melted material, layer by layer, from a movable nozzle onto a base.
Stratasys Inc793 citations
manufacturingmechanicalsoftware
US 5347632 · 1994exp. 2009
Prodigy's System for Interactive Online Information and Shopping
Prodigy's 1994 patent outlines an interactive online system that delivered news, shopping, and banking to personal computers by breaking applications into 'objects' stored locally or remotely, and used user data for targeted ads.
Prodigy Services Co808 citations
telecommunicationssoftwareecommerce
US 5521184 · 1996exp. 2014
New Pyrimidine Chemical Compounds for Treating Tumors
This patent describes specific new chemical compounds, called N-phenyl-2-pyrimidine-amine derivatives, designed with precise molecular structures for potential use in treating cancer.
Ciba Geigy Corp564 citations
pharmaceuticalbiotechchemistry
US 4528643 · 1985exp. 2003
How Stores Make Custom Products On-Demand with Remote Approval
This patent describes a system where a store can make a custom product for a customer, but only after getting permission and the necessary design information from a central, remote office.
FPDC Inc498 citations
consumer_electronicssoftwaretelecommunications
US 3906166 · 1975exp. 1993
How Early Cell Phones Handled Calls Across Different Towers
This patent describes a system for early portable phones to automatically find the strongest signal from a base station and switch channels as the user moves, reducing battery drain and interference.
Motorola Inc206 citations
telecommunicationsconsumer_electronicssoftware
US 4703008 · 1987exp. 2004
How to Make Human Erythropoietin (EPO) Using Engineered DNA
This patent describes the specific DNA sequences and methods to engineer cells to produce erythropoietin (EPO), a protein vital for red blood cell production, outside the human body.
Kirin Amgen Inc346 citations
biotechpharmaceuticalgene_editing
US 4727064 · 1988exp. 2005
How Special Sugars Make Medicines Dissolve Better
This patent describes how to make poorly water-soluble drugs dissolve and absorb better by mixing them with specially modified, non-crystalline sugar molecules called cyclodextrin derivatives.
US Department of Health and Human Services341 citations
pharmaceuticalbiotechmaterials
US 6285999 · 2001exp. 2018
How Websites Get Ranked by Importance
This patent describes a computer method for scoring documents in a linked database, like the internet, by considering the importance of other documents that link to them, helping search engines find better results.
Leland Stanford Junior University818 citations
softwaretelecommunicationsai_ml
US 4665913 · 1987exp. 2005
How Lasers Correct Vision by Reshaping the Eye's Front Surface
This patent describes a method for precisely reshaping the front surface of the eye using an ultraviolet laser to correct vision problems like nearsightedness, farsightedness, and astigmatism.
LRI LP381 citations
medical_devicesbiotechhealthcare
US 5210015 · 1993exp. 2010
How an Enzyme Helps Find Specific DNA in a Sample
This patent describes a method for detecting a specific DNA sequence in a sample by using a labeled DNA probe and an enzyme that cuts the probe, releasing detectable fragments.
Hoffmann La Roche Inc1183 citations
biotechpharmaceuticaldiagnostics
US 5960411 · 1999exp. 2017
How Amazon's One-Click Ordering Works for Online Purchases
Amazon's 1999 patent describes how a customer can buy an item online with just one click, bypassing a traditional shopping cart by using pre-stored payment and shipping information.
Amazon com Inc1636 citations
ecommercesoftwaretelecommunications
US 5471515 · 1995exp. 2014
How a Modern Camera Sensor Captures Light and Converts It to Data
This patent describes a camera sensor technology that combines light-capturing elements with a special circuit to read out the image data quickly and efficiently, all on a single chip.
California Institute of Technology620 citations
consumer_electronicssemiconductorstelecommunications
US 4816567 · 1989exp. 2003
Making Hybrid Antibodies from Different Animals
This patent describes how to create new, engineered antibodies by combining parts of antibodies from two different animal species, then growing them in a lab.
Genentech Inc8214 citations
biotechpharmaceuticalgene_editing
US 4063220 · 1977exp. 1995
How Multiple Computers Share a Network Cable Without Crashing
This patent describes how multiple computers can share a single communication cable by listening for other transmissions and stopping their own if a collision occurs, then trying again later.
Xerox Corp301 citations
telecommunicationssoftwareconsumer_electronics
US 4522811 · 1985exp. 2002
Boosting Anti-Infective Activity with Muramyldipeptides and Liposomes
This patent describes a method to make anti-infective drugs called muramyldipeptides work better by injecting them separately but close in time with tiny fat bubbles called liposomes into an animal.
Syntex USA LLC2340 citations
biotechpharmaceuticaldrug_delivery
US 3778614 · 1973exp. 1991
How Early CT Scans Created Detailed Body Images
This 1973 patent describes a method for using X-rays from many angles to build a detailed 2D image of the inside of a body, like a slice of a CT scan.
EMI Ltd163 citations
biotechmedical_devicessemiconductors
US 7669123 · 2010exp. 2026
Displaying Friends' Activities in a Social Network Feed
This patent describes how social networks like Facebook collect what users do, create short updates about those actions, and show them to specific friends in a personalized list called a "news feed."
Facebook Inc231 citations
social_networksoftwaretelecommunications
US 7653883 · 2010exp. 2025
How Phones Sense Your Finger Hovering Without Touching the Screen
This patent describes a system for electronic devices, like phones, to detect a finger hovering just above the screen, display a specific interactive element below it, and then let you control that element with gestures without ever making contact.
Apple Inc860 citations
consumer_electronicssoftwaretelecommunications
US 4200770 · 1980exp. 1997
How to Create a Secret Code Key Without Meeting First
This 1980 patent describes a way for two people to create a secret code key over a public channel, like the internet, without ever meeting or sharing the key directly.
Leland Stanford Junior University708 citations
telecommunicationssoftwareconsumer_electronics
US 5825352 · 1998exp. 2016
Logitech's Method for Using Two Fingers on a Touchpad
Logitech's 1998 patent describes how a touchpad can detect two fingers touching it in a specific sequence to perform actions like clicking or dragging, going beyond single-finger mouse emulation.
Logitech Inc1577 citations
consumer_electronicssoftwaresemiconductors
US 4558302 · 1985exp. 2003
How Computers Compress Data Using Dictionary Building
This 1985 patent describes a method for making computer files smaller by building a dictionary of common data patterns and replacing them with shorter codes.
Sperry Corp347 citations
softwaretelecommunicationsconsumer_electronics
US 7527791 · 2009exp. 2025
How Engineered Antibodies Target TGF-beta Proteins to Fight Cancer
This patent describes specific engineered antibodies, made from mouse and human parts, designed to block TGF-beta proteins to help treat various cancers like breast or lung cancer.
Genentech Inc756 citations
biotechpharmaceuticaloncology
US 3691140 · 1972exp. 1990
Sticky, Tiny Plastic Balls Made from Acrylates
This 1972 patent describes how to make tiny, sticky, and durable plastic balls (microspheres) using a specific mix of acrylate chemicals and a special water-based process.
382 citations
materialsconsumer_electronicschemicals
US 5487069 · 1996exp. 2013
CSIRO's High-Frequency Wireless Network Technology
This 1996 patent from CSIRO describes a wireless local area network system that can send data reliably using radio waves above 10 GHz, even when signals bounce off walls.
Commonwealth Scientific and Industrial Research Organization CSIRO120 citations
telecommunicationsconsumer_electronicssoftware
US 5325765 · 1994exp. 2012
How Keurig's Original Single-Serve Coffee Pod System Works
This 1994 patent describes the original Keurig system for brewing single cups of coffee using a special filter pod that holds coffee grounds and separates them from the brewed liquid.
Keurig Inc359 citations
consumer_electronicsfood_and_beveragemechanical
US 3803463 · 1974exp. 1992
Weapon That Shoots Wires to Deliver Electric Shocks
This 1974 patent describes a weapon that fires projectiles carrying wires to deliver incapacitating electric shocks to a target from a distance.
152 citations
consumer_electronicsautomotivesecurity
US 5273995 · 1993exp. 2011
How a Cholesterol-Lowering Drug Molecule Was Patented
This patent protects the specific chemical structure of a molecule designed to lower cholesterol, including its various salt forms and its use in medicine.
Warner Lambert Co LLC519 citations
pharmaceuticalbiotech
US 6323846 · 2001exp. 2019
How a Multi-Touch Screen Detects Multiple Fingers and Palms
This patent describes the underlying electronic circuits and methods for a multi-touch surface that can track multiple fingers and palms simultaneously, even before they fully touch the screen.
University of Delaware2641 citations
consumer_electronicssoftwaretelecommunications
US 4195637 · 1980exp. 1997
Catheter System for Opening and Closing Body Passages
This 1980 patent describes a medical catheter system with a guide catheter and a special dilatation catheter that can expand to open or close body passages, like blood vessels.
Schneider Medintag AG256 citations
medical_devicesbiotechpharmaceutical
US 4009052 · 1977exp. 1996
Early Lithium-Ion Battery Design Using Chalcogenides
This 1977 patent describes an early rechargeable battery design using lithium as one electrode and titanium disulfide as the other, a key step towards modern lithium-ion technology.
Exxon Research and Engineering Co93 citations
consumer_electronicssemiconductorsenergy
US 4237224 · 1980exp. 1999
How Scientists First Made DNA Replicate in New Cells
This 1980 patent describes a method for cutting and pasting DNA pieces in a lab to create new, self-replicating genetic material that can be inserted into bacteria, a foundational technique for genetic engineering.
Leland Stanford Junior University346 citations
biotechpharmaceuticalsemiconductors
US 4683194 · 1987exp. 2005
Detecting Genetic Differences Using DNA Probes and Enzymes
This 1987 patent describes a method to find tiny differences in DNA sequences by using special DNA pieces (probes) and cutting enzymes, which can help diagnose genetic conditions like sickle cell anemia.
Cetus Corp289 citations
biotechpharmaceuticalmedical_devices
US 4356429 · 1982exp. 2000
How Organic Diodes Make Light Using Special Molecules
Eastman Kodak's 1982 patent on creating light-emitting diodes (OLEDs) using organic materials, specifically a layer of porphyrinic compounds to help inject electrical charges.
Eastman Kodak Co1031 citations
consumer_electronicssemiconductorsmaterials
US 5961804 · 1999exp. 2017
Tiny Capsules for Electronic Paper Displays
MIT's 1999 patent on a special ink made of tiny capsules that can change color when an electric field is applied, forming the basis for early e-readers.
Massachusetts Institute of Technology508 citations
consumer_electronicssemiconductorsmaterials
US 5272135 · 1993exp. 2011
Preventing Protein Damage with Extra Methionine
This 1993 patent describes how adding extra methionine to protein-based medicines can prevent them from degrading, especially in liquid or semi-solid forms.
Chiron Ophthalmics Inc63 citations
pharmaceuticalbiotechmaterials
US 4736866 · 1988exp. 2004
Mice Engineered to Develop Cancer for Research
Harvard's 1988 patent on genetically engineered mice that carry cancer-causing genes, designed to help scientists study how cancer develops and test treatments.
Harvard University644 citations
biotechpharmaceuticalresearch_tools
US 3789832 · 1974exp. 1992
Using Nuclear Magnetic Resonance to Detect Cancer in Tissue
This 1974 patent describes a method and apparatus using nuclear magnetic resonance (NMR) to measure how quickly certain atomic nuclei in a tissue sample return to their normal energy state, helping to distinguish cancerous from healthy tissue.
83 citations
biotechmedical_devicessemiconductors
US 4723129 · 1988exp. 2006
How Canon's Bubble Jet Printers Make Ink Droplets
Canon's 1988 patent on bubble jet printing uses a tiny heater to instantly vaporize ink, creating a bubble that pushes out a droplet of ink from the printer head.
Canon Inc1806 citations
consumer_electronicssemiconductorsmechanical