Most cited gene editing patents

1

This patent describes how to create new, engineered antibodies by combining parts of antibodies from two different animal species, then growing them in a lab.

2

This patent describes the fundamental three-step process for making millions of copies of a specific piece of DNA using short starter molecules and an enzyme, a technique known as Polymerase Chain Reaction (PCR).

3

This patent describes the Polymerase Chain Reaction (PCR) method, a technique to make millions of copies of a specific DNA segment using a heat-resistant enzyme and repeated temperature changes.

4

This patent describes an engineered CRISPR-Cas9 system for precisely cutting DNA in eukaryotic cells to change how genes work, opening the door for gene editing in complex organisms.

5

This patent describes the specific DNA sequences and methods to engineer cells to produce erythropoietin (EPO), a protein vital for red blood cell production, outside the human body.

6

This patent describes an mRNA vaccine designed to treat prostate cancer by delivering genetic instructions for a specific combination of six prostate-related proteins, teaching the body to fight the cancer.

7

This patent describes the fundamental mechanism of using a two-part RNA system to guide the Cas9 protein to specific locations in DNA for precise editing.

8

A 1987 patent describing a specific synthetic DNA molecule designed to stop the HIV virus from replicating by blocking a key part of its genetic code.

9

This patent describes a method to make plant genetic engineering more efficient by adding specific genes that encourage plant cells to divide and grow, making it easier to create new plants with desired traits.

10

This patent describes a computer system and method for creating a comprehensive library of gene-editing guides (sgRNAs) by carefully designing and filtering them to be accurate and avoid unintended genetic changes.