Most cited gene editing patents

1

This patent describes how to create new, engineered antibodies by combining parts of antibodies from two different animal species, then growing them in a lab.

2

This patent describes the fundamental three-step process for making millions of copies of a specific piece of DNA using short starter molecules and an enzyme, a technique known as Polymerase Chain Reaction (PCR).

3

This patent describes the Polymerase Chain Reaction (PCR) method, a technique to make millions of copies of a specific DNA segment using a heat-resistant enzyme and repeated temperature changes.

4

This patent describes an engineered CRISPR-Cas9 system for precisely cutting DNA in eukaryotic cells to change how genes work, opening the door for gene editing in complex organisms.

5

This patent describes the specific DNA sequences and methods to engineer cells to produce erythropoietin (EPO), a protein vital for red blood cell production, outside the human body.

6

This patent describes an mRNA vaccine designed to treat prostate cancer by delivering genetic instructions for a specific combination of six prostate-related proteins, teaching the body to fight the cancer.

7

This patent describes a specific mRNA vaccine designed to treat lung cancer by instructing the body's cells to produce six distinct tumor proteins, thereby training the immune system to recognize and attack cancer cells.

8

This patent describes how human T cells are genetically engineered to express a special receptor (CAR) that specifically targets and kills cancer cells, particularly those with the CD19 marker, offering a new way to treat cancer.

9

This patent describes the fundamental mechanism of using a two-part RNA system to guide the Cas9 protein to specific locations in DNA for precise editing.

10

This patent describes how to create and use genetically modified human T cells that target and kill cancer cells expressing the CD19 protein, offering a new way to treat blood cancers.

11

A 1987 patent describing a specific synthetic DNA molecule designed to stop the HIV virus from replicating by blocking a key part of its genetic code.

12

This patent describes methods to fight various cancers by using a specific protein fragment (peptide LYHDIFSRL) to train a patient's immune cells to recognize and attack tumor cells.

13

This patent describes special molecules made of a CAR-T cell activator attached to a fat-like part, designed to make cancer-fighting CAR-T cells grow and work better inside a patient.

14

This patent describes a computer system and method for creating a comprehensive library of gene-editing guides (sgRNAs) by carefully designing and filtering them to be accurate and avoid unintended genetic changes.

15

This patent describes a method to make plant genetic engineering more efficient by adding specific genes that encourage plant cells to divide and grow, making it easier to create new plants with desired traits.