Genentech Inc

Making Hybrid Antibodies from Different Animals

This patent describes how to create new, engineered antibodies by combining parts of antibodies from two different animal species, then growing them in a lab.

How Engineered Antibodies Target TGF-beta Proteins to Fight Cancer

This patent describes specific engineered antibodies, made from mouse and human parts, designed to block TGF-beta proteins to help treat various cancers like breast or lung cancer.

How to Redesign Mouse Antibodies for Safe Use in Humans

Genentech's 1995 patent on a systematic method for humanizing rodent antibodies by grafting their disease-targeting loops onto a human consensus framework while carefully swapping key structural support residues to maintain binding strength.

Making High-Concentration Antibody Medicines Stable for Injection

Genentech's 2001 patent on a method to create stable, concentrated antibody medicines that can be easily reconstituted for injection, preventing degradation during freezing and storage.

How Genentech Created Antibodies to Stop Tumor Growth

A 1997 patent describing a specific humanized antibody designed to block VEGF, a protein that helps tumors grow their own blood supply.

How Genentech's Antibody Targets Cancerous B Cells

This patent describes a specific humanized antibody designed to bind to a protein called CD79b, which is found on the surface of certain cancer cells.

How Scientists Taught Bacteria to Make Human Hormones

Genentech's 1979 patent on using engineered DNA to force bacteria to produce human proteins like insulin and growth hormones.

How Genentech Engineered Antibodies to Starve Tumors of Blood

A 2007 Genentech patent describing specific lab-made antibodies that block a protein called VEGF, which tumors use to grow new blood vessels.

How Genentech Created Antibodies to Target Prostate Cancer Cells

A patent describing specific antibodies that latch onto and kill cancer cells expressing the PSCA protein, effectively turning the body's immune-targeting tools into cancer-fighting weapons.

How Genentech Purifies Therapeutic Antibodies for Cancer Treatment

A method for refining mixtures of anti-HER2 antibodies to ensure that harmful acidic variants remain below 25 percent of the total composition.

How Genentech's Antibodies Stop Tumor Blood Vessel Growth

A Genentech patent for specific lab-made antibodies that block a protein called VEGF, effectively starving tumors of the blood supply they need to grow.

How Antibodies Can Force Cancer Cells to Self-Destruct

Genentech's patent on specific antibodies that bind to the Apo-2 receptor to trigger programmed cell death in cancer cells.

How Genentech Engineered Antibodies to Block the Bv8 Protein

This patent details specific genetic blueprints for creating antibodies that target and neutralize Bv8, a protein often associated with tumor growth and inflammation.