Massachusetts Institute of Technology

How to Edit Genes in Human Cells Using an Engineered CRISPR System

This patent describes an engineered CRISPR-Cas9 system for precisely cutting DNA in eukaryotic cells to change how genes work, opening the door for gene editing in complex organisms.

How RSA Public-Key Encryption Keeps Digital Messages Secret

This patent describes the foundational RSA algorithm, a method for securely sending messages where anyone can encrypt a message using a public key, but only the intended recipient can decrypt it using a secret private key.

Tiny Capsules for Electronic Paper Displays

MIT's 1999 patent on a special ink made of tiny capsules that can change color when an electric field is applied, forming the basis for early e-readers.

Delivering Large Gene Editing Tools into Cells with Hybrid Virus-Lipid Packages

This patent describes a sophisticated delivery system that combines parts of a virus with a fat bubble (liposome) to efficiently transport large molecules, like CRISPR gene-editing components, into specific cells.

New Nanoparticles for Delivering Large RNA Medicines to Cells

This patent describes a specific type of modified dendrimer nanoparticle designed to efficiently deliver large RNA molecules, like replicating RNA, into cells for therapeutic, prophylactic, or diagnostic purposes, notably without using cholesterol.

Combining Radio Signals Efficiently with Special Wires

MIT's 2015 patent describes a clever way to combine multiple radio signals using specific lengths of transmission lines to boost power efficiently and linearly.

How to Make Animals That Can Turn On CRISPR Gene Editing

This patent describes creating genetically modified non-human animals, like mice, where a key CRISPR gene-editing protein (Cas9) can be turned on only in specific cells or at specific times using a special genetic switch.

How to Use Many CRISPR Guides to Study Many Genes at Once

This patent describes a method to use a large collection of CRISPR-Cas9 guide RNAs to target and modify many different genes or DNA regions across a population of eukaryotic cells, enabling high-throughput genetic screening.

Highly Efficient Bacterial Gene Editing Using Guide RNA and Reverse Transcriptase

This patent describes a system for precisely editing the DNA of bacterial cells with very high success rates, using a combination of guide RNA, reverse transcriptase, and specific DNA sequences.

How Special Molecules Boost Cancer-Fighting CAR-T Cells

This patent describes special molecules made of a CAR-T cell activator attached to a fat-like part, designed to make cancer-fighting CAR-T cells grow and work better inside a patient.