Massachusetts Institute of Technology

How to Edit Genes in Human Cells Using an Engineered CRISPR System

This patent describes an engineered CRISPR-Cas9 system for precisely cutting DNA in eukaryotic cells to change how genes work, opening the door for gene editing in complex organisms.

How RSA Public-Key Encryption Keeps Digital Messages Secret

This patent describes the foundational RSA algorithm, a method for securely sending messages where anyone can encrypt a message using a public key, but only the intended recipient can decrypt it using a secret private key.

Tiny Capsules for Electronic Paper Displays

MIT's 1999 patent on a special ink made of tiny capsules that can change color when an electric field is applied, forming the basis for early e-readers.

Delivering Large Gene Editing Tools into Cells with Hybrid Virus-Lipid Packages

This patent describes a sophisticated delivery system that combines parts of a virus with a fat bubble (liposome) to efficiently transport large molecules, like CRISPR gene-editing components, into specific cells.

How to Make Animals That Can Turn On CRISPR Gene Editing

This patent describes creating genetically modified non-human animals, like mice, where a key CRISPR gene-editing protein (Cas9) can be turned on only in specific cells or at specific times using a special genetic switch.

Highly Efficient Bacterial Gene Editing Using Guide RNA and Reverse Transcriptase

This patent describes a system for precisely editing the DNA of bacterial cells with very high success rates, using a combination of guide RNA, reverse transcriptase, and specific DNA sequences.

How Special Molecules Boost Cancer-Fighting CAR-T Cells

This patent describes special molecules made of a CAR-T cell activator attached to a fat-like part, designed to make cancer-fighting CAR-T cells grow and work better inside a patient.