How to Make Very Pure Phentolamine Mesylate for Medicine
This patent describes a specific chemical recipe using acetone and water to create a very pure version of phentolamine mesylate, a drug used in medicine.
Original patent title: “Highly pure phentolamine mesylate and methods for making same”
This patent describes a specific chemical recipe using acetone and water to create a very pure version of phentolamine mesylate, a drug used in medicine. Granted in 2026.
Coverage
What does this patent actually cover?
This invention provides a specific method for creating phentolamine mesylate, a chemical compound used as a drug. The process involves combining two starting ingredients: phentolamine and methanesulfonic acid. Crucially, this reaction takes place in a specific mixture of solvents: acetone and water. This particular combination of ingredients and solvents is designed to produce 'highly pure' phentolamine mesylate, meaning the final product contains very few unwanted impurities. For example, a drug manufacturer could use this method to ensure their phentolamine mesylate meets strict pharmaceutical purity standards.
The gap
What does this patent NOT cover?
- Does not cover methods for synthesizing phentolamine mesylate using different solvents, such as ethanol or methanol, instead of acetone and water.
- Does not cover purification techniques that do not involve the specific reaction conditions described, even if they yield high purity.
- Does not cover phentolamine mesylate produced with lower purity levels that are not considered 'highly pure'.
- Does not cover the use of starting materials other than phentolamine and methanesulfonic acid to create the drug.
- Does not cover the medical uses or applications of phentolamine mesylate itself, only its method of creation.
These exclusions are unique to PatentBrief — derived from the actual claim language, not patent-office boilerplate.
Key facts
What made this novel
The clever part of this invention is identifying the specific combination of acetone and water as solvents during the synthesis process. This particular solvent system allows for the creation of phentolamine mesylate with exceptionally high purity, which is a significant advantage in drug manufacturing.
Schematic visualization of the patent's claim structure. Hand-drawn diagrams in progress for each landmark patent.
Where you've seen this
Real-world examples
OraVerse (phentolamine mesylate injection)
Regitine (older brand of phentolamine mesylate)
Generic phentolamine mesylate products used in hospitals and clinics
Why it matters
The bigger picture
Phentolamine mesylate is an important drug used in medicine, for example, to reverse the effects of local anesthesia or to treat certain blood pressure conditions. For any drug, purity is extremely important to ensure it is safe and effective for patients. This patent matters because it offers a specific, reliable way to produce a very clean version of this drug, which is critical for meeting strict health regulations and ensuring patient safety.
Filed
March 28, 2024
Granted
September 15, 2026
Market context
Who's building on this
Companies in this space
Pharmaceutical companies that manufacture generic versions of phentolamine mesylate or develop new drug formulations requiring high purity are likely to be interested in or building upon similar chemical synthesis methods. Companies focused on active pharmaceutical ingredient (API) production would also be key players in this space.
Market impact
A reliable and efficient method for producing highly pure phentolamine mesylate can significantly impact the pharmaceutical market. It can lead to more cost-effective manufacturing processes, potentially lowering drug prices or improving profit margins for producers. Furthermore, enhanced purity can simplify regulatory approval processes and reduce the risk of adverse drug reactions, thereby improving patient safety and market confidence in the drug.
Claim 1 — Plain English
What this patent covers
This invention provides a specific method for creating phentolamine mesylate, a chemical compound used as a drug. The process involves combining two starting ingredients: phentolamine and methanesulfonic acid. Crucially, this reaction takes place in a specific mixture of solvents: acetone and water. This particular combination of ingredients and solvents is designed to produce 'highly pure' phentolamine mesylate, meaning the final product contains very few unwanted impurities. For example, a drug manufacturer could use this method to ensure their phentolamine mesylate meets strict pharmaceutical purity standards.
The clever bit
The clever part of this invention is identifying the specific combination of acetone and water as solvents during the synthesis process. This particular solvent system allows for the creation of phentolamine mesylate with exceptionally high purity, which is a significant advantage in drug manufacturing.
What it does not cover
- Does not cover methods for synthesizing phentolamine mesylate using different solvents, such as ethanol or methanol, instead of acetone and water.
- Does not cover purification techniques that do not involve the specific reaction conditions described, even if they yield high purity.
- Does not cover phentolamine mesylate produced with lower purity levels that are not considered 'highly pure'.
- Does not cover the use of starting materials other than phentolamine and methanesulfonic acid to create the drug.
- Does not cover the medical uses or applications of phentolamine mesylate itself, only its method of creation.
Patent timeline
Application submitted to the patent office
Patent officially issued
PatentBrief Score
Impact Score
Early stage
Citation count
0/40
No citations yet
Claim breadth
0/20
Narrow claimsclaimsThe numbered statements at the end of a patent that legally define what the inventor owns.Read more →
Recency
20/20
Granted within 5 years
Assignee scale
0/20
Independent or smaller assigneeassigneeThe entity that owns the patent — usually the inventor's employer or a company.Read more →
PatentBrief Impact Score — based on citation count, claim breadth, recency, and assignee scale. Not a legal assessment.
Heuristic Value Estimate
What this patent might be worth
$36K – $115K
Midpoint $72K · 17.5 yr remaining · industry ×3.0
Heuristic only — blends forward/backward citation counts, claim scope, time remaining, litigation history, and CPC-derived industry baseline. Real valuations need a professional appraisal.
Claim text not yet imported for this patent
Concepts involved
Cite this patent
(2026). How to Make Very Pure Phentolamine Mesylate for Medicine (U.S. Patent No. 12,735,389). U.S. Patent and Trademark Office. https://patentbrief.org/patent/us/12735389/highly-pure-phentolamine-mesylate-and-methods-for-making-same
Auto-generated from the patent record. Double-check author order and the issue date against the official USPTO document before submitting.
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Common Questions
Frequently Asked Questions
What does How to Make Very Pure Phentolamine Mesylate for Medicine cover?
This patent describes a specific chemical recipe using acetone and water to create a very pure version of phentolamine mesylate, a drug used in medicine.
When does this patent expire?
This patent is expected to expire on September 15, 2046, when the invention enters the public domain.
What problem does this patent solve?
Phentolamine mesylate is an important drug used in medicine, for example, to reverse the effects of local anesthesia or to treat certain blood pressure conditions. For any drug, purity is extremely important to ensure it is safe and effective for patients. This patent matters because it offers a specific, reliable way to produce a very clean version of this drug, which is critical for meeting strict health regulations and ensuring patient safety.
What does this patent NOT cover?
Does not cover methods for synthesizing phentolamine mesylate using different solvents, such as ethanol or methanol, instead of acetone and water.
Patent monitoring