How to Make Very Pure Phentolamine Mesylate for Medicine

This patent describes a specific chemical recipe using acetone and water to create a very pure version of phentolamine mesylate, a drug used in medicine.

What it covers

This invention provides a specific method for creating phentolamine mesylate, a chemical compound used as a drug. The process involves combining two starting ingredients: phentolamine and methanesulfonic acid. Crucially, this reaction takes place in a specific mixture of solvents: acetone and water. This particular combination of ingredients and solvents is designed to produce 'highly pure' phentolamine mesylate, meaning the final product contains very few unwanted impurities. For example, a drug manufacturer could use this method to ensure their phentolamine mesylate meets strict pharmaceutical purity standards.

What it doesn't cover

• —Does not cover methods for synthesizing phentolamine mesylate using different solvents, such as ethanol or methanol, instead of acetone and water.
• —Does not cover purification techniques that do not involve the specific reaction conditions described, even if they yield high purity.
• —Does not cover phentolamine mesylate produced with lower purity levels that are not considered 'highly pure'.
• —Does not cover the use of starting materials other than phentolamine and methanesulfonic acid to create the drug.
• —Does not cover the medical uses or applications of phentolamine mesylate itself, only its method of creation.

The clever bit

The clever part of this invention is identifying the specific combination of acetone and water as solvents during the synthesis process. This particular solvent system allows for the creation of phentolamine mesylate with exceptionally high purity, which is a significant advantage in drug manufacturing.

Why it matters

Phentolamine mesylate is an important drug used in medicine, for example, to reverse the effects of local anesthesia or to treat certain blood pressure conditions. For any drug, purity is extremely important to ensure it is safe and effective for patients. This patent matters because it offers a specific, reliable way to produce a very clean version of this drug, which is critical for meeting strict health regulations and ensuring patient safety.

Real-world examples

• 1.OraVerse (phentolamine mesylate injection)
• 2.Regitine (older brand of phentolamine mesylate)
• 3.Generic phentolamine mesylate products used in hospitals and clinics