Methods and compositions for selecting siRNA of improved functionality
Efficient sequence specific gene silencing is possible through the use of siRNA technology. Be selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as we
Patent Number
US 9839649
Status
Active
Filing Date
November 9, 2015
Grant Date
December 12, 2017
Expiration
~November 2035 (estimated)
Claims
14
Assignee
Thermo Fisher Scientific Inc
Inventors
Anastasia Khvorova, Angela Reynolds, Devin Leake, William Marshall, Steven Read, Stephen Scaringe
Citations
3 forward · 208 backward
What it covers
Efficient sequence specific gene silencing is possible through the use of siRNA technology. Be selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods compositions, and kits generated through rational design of siRNAs are disclosed, including those directed to the nucleotide sequences for AAT.
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US 9839649 · 2026