How Tiny Particles Make CBD Easier to Absorb

This patent describes a special mix of ingredients that creates tiny, stable CBD particles, making it easier for the body to absorb the compound and improving how long it lasts in the body.

What it covers

This patent covers a lipid-based nanoparticle composition designed to deliver cannabidiol (CBD). The composition is an oil-in-water nanoemulsion, meaning tiny oil droplets containing CBD are evenly spread in water. It includes specific amounts of CBD (1-10%), phosphatidylcholine (2.5-15%), a sterol (0.5-5%), and a medium chain triglyceride (2.5-15%), with water making up 60-80% of the mix (Claim 1). The nanoparticles are very small, averaging 75 nm to 200 nm, which helps with absorption. A key feature is their stability: the nanoparticles change size by less than 10% when exposed to simulated stomach or intestinal fluids for at least an hour (Claim 1). This stability helps the CBD survive digestion and get into the bloodstream more effectively, potentially leading to faster absorption (Tmax less than 4.5 hours, Claim 3) and higher concentrations in the body (Cmax of at least 80 ng/ml after 15 mg/kg dose, Claim 13). For example, a person could take this composition orally, and the CBD would be absorbed more efficiently than other forms.

What it doesn't cover

• —Does not cover CBD compositions that use traditional surfactants or emulsifiers other than phosphatidylcholine (Claim 1).
• —Does not cover compositions where the CBD, phosphatidylcholine, sterol, or medium chain triglyceride fall outside the specified weight percentages (Claim 1).
• —Does not cover nanoparticles that change size by more than 10% when exposed to simulated gastric or intestinal fluids (Claim 1).
• —Does not cover compositions where the average nanoparticle size is outside the 75 nm to 200 nm range (Claim 1).
• —Does not cover the delivery of therapeutic agents other than cannabidiol (CBD) using this specific composition (Claim 1).

The clever bit

The clever part is creating a highly stable, small-particle CBD nanoemulsion without relying on common synthetic surfactants. By using specific ratios of natural lipids like phosphatidylcholine and sterols, the composition achieves excellent stability in harsh digestive environments and enhances the body's ability to absorb CBD.

Why it matters

Many beneficial compounds, like CBD, are not easily absorbed by the body when taken orally. This patent provides a way to create a stable, highly absorbable form of CBD, which can improve its effectiveness for consumers. By ensuring the nanoparticles remain stable through the digestive system, it addresses a major challenge in delivering lipid-soluble compounds. This technology could lead to more reliable and potent CBD products, enhancing their therapeutic potential.

Real-world examples

• 1.CBD oil tinctures designed for enhanced bioavailability
• 2.CBD-infused beverages
• 3.CBD capsules or softgels with improved absorption
• 4.Topical CBD creams or lotions using nanoemulsion technology