Kary B. Mullis

How to Make Billions of Copies of a DNA Segment

This patent describes the Polymerase Chain Reaction (PCR), a method to rapidly create many copies of a specific piece of DNA or RNA, enabling its detection and analysis.

How to Make Many Copies of a DNA Piece with Heat

This patent describes the Polymerase Chain Reaction (PCR) method, a technique to make millions of copies of a specific DNA segment using a heat-resistant enzyme and repeated temperature changes.

How to Make Many Copies of a Specific DNA Segment

This patent describes the fundamental three-step process for making millions of copies of a specific piece of DNA using short starter molecules and an enzyme, a technique known as Polymerase Chain Reaction (PCR).

Using PCR to Detect Viruses in Blood and Tissue Samples

A 1989 patent by Nobel laureate Kary Mullis and his team on using polymerase chain reaction (PCR) to replicate and detect tiny amounts of viral DNA or RNA, such as HIV and Hepatitis B, directly from human clinical samples.