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US 6682736

How Human Antibodies Block the Immune System's Off-Switch

Abgenix's 1999 patent on fully human monoclonal antibodies that bind to CTLA-4, a protein brake on the immune system, allowing T-cells to stay active and attack cancer cells.

Statusactive

Granted2004

Expires2019

Claims123

Forward citations500

Prior art96

AssigneeAbgenix Inc

InventorsJose Ramon Corvalan, Steven Christopher Gilman +5

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