{
  "patent_number": "US RE50301",
  "country": "US",
  "title": "How to Make Long-Lasting Injections for Multiple Sclerosis Treatment",
  "original_title": "USRE50301E1 - Depot systems comprising glatiramer or pharmacologically acceptable salt thereof",
  "summary": "A patent for a slow-release version of the MS drug glatiramer acetate, designed to be injected once every week to six months instead of daily.",
  "what_it_does": "This patent describes a way to package the drug glatiramer acetate—commonly used for multiple sclerosis—into a 'depot' form. Instead of the drug being absorbed by the body all at once, it is trapped inside a carrier material, such as biodegradable microspheres made of polymers like PLGA. This allows the medication to be released slowly into the patient's system over a period ranging from one week to six months. By using a double-emulsification process, the drug is kept in an internal phase that gradually leaks out, aiming to maintain therapeutic levels in the blood without the need for daily injections.",
  "what_it_does_not_cover": [
    "Does not cover the chemical structure of glatiramer acetate itself, which is a known drug.",
    "Does not cover immediate-release formulations that are injected daily.",
    "Does not cover non-depot delivery methods like oral pills or intravenous drips.",
    "Does not cover specific medical devices or needles used to deliver the injection."
  ],
  "filed": "2022-08-24",
  "granted": "2025-02-18",
  "expires": null,
  "status": "active",
  "holder": "Mapi Pharma Ltd",
  "holder_url": "https://patentbrief.org/company/mapi-pharma-ltd",
  "inventors": [
    {
      "name": "Shai Rubnov",
      "url": "https://patentbrief.org/inventor/shai-rubnov"
    },
    {
      "name": "Ehud Marom",
      "url": "https://patentbrief.org/inventor/ehud-marom"
    }
  ],
  "times_cited": 0,
  "tags": [
    "biotech",
    "pharmaceutical"
  ],
  "abstract": "Long acting parenteral pharmaceutical compositions comprising a therapeutically effective amount of glatiramer are provided. In particular, the present invention provides a long acting pharmaceutical composition comprising a therapeutically effective amount of glatiramer acetate in depot form suitable for administering at a medically acceptable location in a subject in need thereof. The depot form is suitable for subcutaneous or intramuscular implantation or injection.",
  "url": "https://patentbrief.org/patent/us/RE50301/temperature-controlled-mug",
  "markdown_url": "https://patentbrief.org/patent/us/RE50301/temperature-controlled-mug/md",
  "google_patents_url": "https://patents.google.com/patent/USRE50301",
  "relatedPatents": []
}