{
  "patent_number": "US RE48183",
  "country": "US",
  "title": "How a Specific Eye Drop Formula Treats Glaucoma",
  "original_title": "USRE48183E1 - Pharmaceutical formulations comprising a pyridylaminoacetic acid compound",
  "summary": "A patent for a precise, low-concentration eye drop solution designed to lower eye pressure in patients with glaucoma or ocular hypertension.",
  "what_it_does": "This patent covers a specific pharmaceutical liquid formulation used as an eye drop to treat glaucoma. The active ingredient is a chemical compound called isopropyl(6-{[4-(pyrazol-1-yl)benzyl](pyridin-3-ylsulfonyl)aminomethyl}pyridin-2-ylamino)acetate. The claims define a very narrow concentration range of this ingredient, specifically between 0.001% and 0.003% (weight/volume), while maintaining a pH balance between 4.0 and 8.0. This precise mixture is intended to be applied directly to the eye to reduce intraocular pressure.",
  "what_it_does_not_cover": [
    "Does not cover concentrations of the active ingredient outside the 0.001% to 0.003% (w/v) range.",
    "Does not cover formulations with a pH level outside the 4.0 to 8.0 range.",
    "Does not cover the chemical compound itself, only this specific pharmaceutical preparation.",
    "Does not cover delivery methods other than eye drops or topical instillation."
  ],
  "filed": "2018-08-28",
  "granted": "2020-09-01",
  "expires": null,
  "status": "active",
  "holder": "Santen Pharmaceutical Co Ltd",
  "holder_url": "https://patentbrief.org/company/santen-pharmaceutical-co-ltd",
  "inventors": [
    {
      "name": "Henk-Andre Kroon",
      "url": "https://patentbrief.org/inventor/henk-andre-kroon"
    },
    {
      "name": "Naveed Shams",
      "url": "https://patentbrief.org/inventor/naveed-shams"
    },
    {
      "name": "Hisashi Kawata",
      "url": "https://patentbrief.org/inventor/hisashi-kawata"
    },
    {
      "name": "Noriko Kawabata",
      "url": "https://patentbrief.org/inventor/noriko-kawabata"
    }
  ],
  "times_cited": 1,
  "tags": [
    "biotech",
    "pharmaceutical"
  ],
  "abstract": "Provided is a pharmaceutical preparation for treatment or prevention of glaucoma or ocular hypertension, comprising 0.0003 to 0.01% (w/v) of isopropyl (6-{[4-(pyrazol-1-yl)benzyl] (pyridin-3-ylsulfonyl)aminomethyl}pyridin-2-ylamino) acetate, or a salt thereof. The pharmaceutical preparation has an excellent intraocular pressure lowering effect and may be used as a therapeutic or preventive agent for glaucoma or ocular hypertension or an intraocular pressure lowering agent.",
  "url": "https://patentbrief.org/patent/us/RE48183/trikafta-triple-combination",
  "markdown_url": "https://patentbrief.org/patent/us/RE48183/trikafta-triple-combination/md",
  "google_patents_url": "https://patents.google.com/patent/USRE48183",
  "relatedPatents": []
}