# How Bayer's Engineered Antibodies Help Blood Clotting > This patent describes specific engineered antibodies designed to block a protein that prevents blood clotting, potentially helping people with bleeding disorders. - **Patent:** US RE47150 - **Original title:** USRE47150E1 - Optimized monoclonal antibodies against tissue factor pathway inhibitor (TFPI) - **Owner:** Bayer Healthcare LLC - **Granted:** 2018 - **Status:** Active - **Times cited:** 0 - **Field:** biotech, pharmaceutical ## What it does The patent covers a specific type of human monoclonal IgG antibody that binds to a protein called Tissue Factor Pathway Inhibitor (TFPI). TFPI normally acts as a brake on the body's blood-clotting process. By binding to and inhibiting TFPI, these engineered antibodies effectively remove that brake, which can help promote clotting in patients who have deficiencies in their blood coagulation system. The claims specify exact amino acid sequences and precise substitutions (like K55Y or D62R) within the antibody's binding regions (CDRs) to ensure the antibody attaches to TFPI with high specificity. ## What it does NOT cover - Does not cover naturally occurring antibodies found in the human body. - Does not cover antibodies that bind to proteins other than TFPI. - Does not cover therapeutic methods that use small-molecule drugs instead of monoclonal antibodies. - Does not cover antibodies lacking the specific amino acid substitutions defined in the claims. ## The clever bit The innovation lies in the specific amino acid 'tuning' of the antibody's binding loops (CDRs). By making precise substitutions at key positions, the inventors increased the antibody's affinity for TFPI, making the treatment more potent and effective at lower doses. ## Real-world examples 1. Experimental hemophilia therapies 2. Targeted monoclonal antibody drug candidates for coagulation disorders ## Why it matters This technology is significant for treating hemophilia and other bleeding disorders where the body struggles to form stable clots. By targeting TFPI, these antibodies offer an alternative approach to traditional factor replacement therapies, which require frequent injections. This patent represents a core intellectual property asset for Bayer in the development of potential hemophilia treatments. ## Frequently asked questions ### What does How Bayer's Engineered Antibodies Help Blood Clotting cover? This patent describes specific engineered antibodies designed to block a protein that prevents blood clotting, potentially helping people with bleeding disorders. ### Who owns patent US RE47150? Bayer Healthcare LLC owns this patent, granted in 2018. ### When does this patent expire? This patent is expected to expire on December 4, 2038, when the invention enters the public domain. ### What problem does this patent solve? This technology is significant for treating hemophilia and other bleeding disorders where the body struggles to form stable clots. By targeting TFPI, these antibodies offer an alternative approach to traditional factor replacement therapies, which require frequent injections. This patent represents a core intellectual property asset for Bayer in the development of potential hemophilia treatments. ### What does this patent NOT cover? Does not cover naturally occurring antibodies found in the human body. **Full plain-English explainer:** https://patentbrief.org/patent/us/RE47150/cosentyx-secukinumab **Original patent:** https://patents.google.com/patent/USRE47150 --- _Source: PatentBrief — https://patentbrief.org. Patent facts are from public records; the plain-English explanation is PatentBrief's._ ## Related patents Semantically similar inventions in the PatentBrief corpus: - [Using Antibodies to Target Tissue Factor Without Stopping Blood Clotting](https://patentbrief.org/patent/us/7993644/stelara-ustekinumab) — A patent describing specific antibodies that attach to a protein called tissue factor without interfering with the body's natural blood-clotting process. - [How to Engineer Antibodies to Better Target and Destroy Disease](https://patentbrief.org/patent/us/10184000/libtayo-cemiplimab) — This patent describes a way to modify the tail end of an antibody so it binds more strongly to immune cells, helping the body fight off infections or cancer more effectively. - [How Engineered Antibodies Block Inflammation-Causing Proteins](https://patentbrief.org/patent/us/7070775/humira-formulation) — A patent describing lab-made antibodies designed to hunt down and neutralize a specific protein called TNF-alpha that causes chronic inflammation in the body. - [Antibodies That Block Tumor Necrosis Factor Alpha (TNFα)](https://patentbrief.org/patent/us/6090382/humira-adalimumab) — This 2000 patent describes specific human antibodies designed to strongly bind and neutralize a protein called TNFα, which is linked to inflammation and autoimmune diseases. - [How Novartis Engineered Antibodies to Block the TIM-3 Immune Checkpoint](https://patentbrief.org/patent/us/10472419/keytruda-pembrolizumab) — A patent describing specific genetic blueprints for antibodies designed to bind to and inhibit the TIM-3 protein, a key target in cancer and immune system research.