{
  "patent_number": "US RE47150",
  "country": "US",
  "title": "How Bayer's Engineered Antibodies Help Blood Clotting",
  "original_title": "USRE47150E1 - Optimized monoclonal antibodies against tissue factor pathway inhibitor (TFPI)",
  "summary": "This patent describes specific engineered antibodies designed to block a protein that prevents blood clotting, potentially helping people with bleeding disorders.",
  "what_it_does": "The patent covers a specific type of human monoclonal IgG antibody that binds to a protein called Tissue Factor Pathway Inhibitor (TFPI). TFPI normally acts as a brake on the body's blood-clotting process. By binding to and inhibiting TFPI, these engineered antibodies effectively remove that brake, which can help promote clotting in patients who have deficiencies in their blood coagulation system. The claims specify exact amino acid sequences and precise substitutions (like K55Y or D62R) within the antibody's binding regions (CDRs) to ensure the antibody attaches to TFPI with high specificity.",
  "what_it_does_not_cover": [
    "Does not cover naturally occurring antibodies found in the human body.",
    "Does not cover antibodies that bind to proteins other than TFPI.",
    "Does not cover therapeutic methods that use small-molecule drugs instead of monoclonal antibodies.",
    "Does not cover antibodies lacking the specific amino acid substitutions defined in the claims."
  ],
  "filed": "2011-03-01",
  "granted": "2018-12-04",
  "expires": null,
  "status": "active",
  "holder": "Bayer Healthcare LLC",
  "holder_url": "https://patentbrief.org/company/bayer-healthcare-llc",
  "inventors": [
    {
      "name": "Simone Brückner",
      "url": "https://patentbrief.org/inventor/simone-brckner"
    },
    {
      "name": "Joanna Grudzinska-Goebel",
      "url": "https://patentbrief.org/inventor/joanna-grudzinska-goebel"
    },
    {
      "name": "Nina Wobst",
      "url": "https://patentbrief.org/inventor/nina-wobst"
    },
    {
      "name": "Jan Tebbe",
      "url": "https://patentbrief.org/inventor/jan-tebbe"
    },
    {
      "name": "Junliang Pan",
      "url": "https://patentbrief.org/inventor/junliang-pan"
    },
    {
      "name": "Joerg Birkenfeld",
      "url": "https://patentbrief.org/inventor/joerg-birkenfeld"
    },
    {
      "name": "Peter Scholz",
      "url": "https://patentbrief.org/inventor/peter-scholz"
    },
    {
      "name": "Christian Votsmeier",
      "url": "https://patentbrief.org/inventor/christian-votsmeier"
    },
    {
      "name": "Zhuozhi Wang",
      "url": "https://patentbrief.org/inventor/zhuozhi-wang"
    },
    {
      "name": "Susanne Steinig",
      "url": "https://patentbrief.org/inventor/susanne-steinig"
    }
  ],
  "times_cited": 0,
  "tags": [
    "biotech",
    "pharmaceutical"
  ],
  "abstract": "Isolated monoclonal antibodies that bind human tissue factor pathway inhibitor (TFPI) are provided. Isolated nucleic acid molecules encoding monoclonal antibodies that bind TFPI are also contemplated. Pharmaceutical compositions comprising the anti-TFPI monoclonal antibodies and methods of treating deficiencies or defects in coagulation by administration of the antibodies are also provided. Methods of producing the antibodies are also provided.",
  "url": "https://patentbrief.org/patent/us/RE47150/cosentyx-secukinumab",
  "markdown_url": "https://patentbrief.org/patent/us/RE47150/cosentyx-secukinumab/md",
  "google_patents_url": "https://patents.google.com/patent/USRE47150",
  "relatedPatents": []
}