{
  "patent_number": "US RE46907",
  "country": "US",
  "title": "Using Plant-Derived Chemicals and Metabolic Drugs to Fight Cancer",
  "original_title": "USRE46907E1 - Suppression of cancer growth and metastasis using nordihydroguaiaretic acid derivatives with metabolic modulators",
  "summary": "A medical patent describing a combination therapy that pairs specific plant-derived compounds with metabolic drugs to kill cancer cells more effectively than either could alone.",
  "what_it_does": "This patent describes a way to treat cancer by combining a derivative of nordihydroguaiaretic acid (NDGA)—specifically M4N or maltose-M3N—with a metabolic modulator. A metabolic modulator is a drug that changes how cells process energy, such as rapamycin or everolimus. The key innovation is that these two components work together synergistically, meaning the combined effect is greater than the sum of their individual effects. By targeting the energy metabolism of rapidly dividing cancer cells while simultaneously introducing the NDGA derivative, the treatment aims to shrink tumors and stop them from spreading (metastasis).",
  "what_it_does_not_cover": [
    "Does not cover the use of NDGA derivatives alone without a metabolic modulator.",
    "Does not cover metabolic modulators used in isolation for cancer treatment.",
    "Does not cover any metabolic modulators outside the specific list provided, such as Ly294002, rottlerin, dichloroacetate, rapamycin, everolimus, or temsirolimus.",
    "Does not cover non-pharmaceutical or non-synergistic applications of these compounds."
  ],
  "filed": "2009-01-08",
  "granted": "2018-06-26",
  "expires": null,
  "status": "active",
  "holder": "Johns Hopkins University",
  "holder_url": "https://patentbrief.org/company/johns-hopkins-university",
  "inventors": [
    {
      "name": "Kotohiko Kimura",
      "url": "https://patentbrief.org/inventor/kotohiko-kimura"
    },
    {
      "name": "Ru Chih C. Huang",
      "url": "https://patentbrief.org/inventor/ru-chih-c-huang"
    }
  ],
  "times_cited": 1,
  "tags": [
    "biotech",
    "pharmaceutical"
  ],
  "abstract": "Disclosed is a composition comprising a derivative of NDGA and at least one metabolic modulator. The composition can be in a unit dose form or kit. The composition can comprise at least two metabolic modulators. Also disclosed are methods for achieving cytotoxicity, particularly of rapidly dividing cells such as cancer, by administering a composition of the invention. In various embodiments of the invention subjects with cancer achieve prolonged survival and/or diminution in the size of their malignancies and cancer metastasis.",
  "url": "https://patentbrief.org/patent/us/RE46907/descovy-taf-ftc",
  "markdown_url": "https://patentbrief.org/patent/us/RE46907/descovy-taf-ftc/md",
  "google_patents_url": "https://patents.google.com/patent/USRE46907",
  "relatedPatents": []
}