{
  "patent_number": "US RE46290",
  "country": "US",
  "title": "Using the Drug TIC10 to Treat Brain Cancer",
  "original_title": "USRE46290E1 - Small molecule trail gene induction by normal and tumor cells as an anticancer therapy",
  "summary": "A patent for using a specific small molecule drug called TIC10 to treat brain cancers like glioblastoma by triggering a natural cell-death process.",
  "what_it_does": "This patent describes a method for treating brain cancer by administering a specific chemical compound known as TIC10. The compound works by inducing the expression of a protein called TRAIL, which signals cancer cells to undergo apoptosis, or programmed cell death. The claims cover using this drug alone or in combination with other anti-cancer or anti-angiogenic agents, such as bevacizumab, to fight tumors. It also includes methods for monitoring the treatment's success by measuring TRAIL levels in a patient's blood or cerebrospinal fluid.",
  "what_it_does_not_cover": [
    "Does not cover the use of TIC10 for treating diseases other than cancer.",
    "Does not cover chemical compounds that do not match the specific structure defined as Formula (I).",
    "Does not cover general immunotherapy methods that do not rely on the specific TRAIL-induction mechanism of TIC10.",
    "Does not cover diagnostic methods that do not involve assessing TRAIL levels as a marker for treatment effectiveness."
  ],
  "filed": "2015-09-17",
  "granted": "2017-01-31",
  "expires": null,
  "status": "active",
  "holder": "Penn State Research Foundation",
  "holder_url": "https://patentbrief.org/company/penn-state-research-foundation",
  "inventors": [
    {
      "name": "Gen Sheng Wu",
      "url": "https://patentbrief.org/inventor/gen-sheng-wu"
    },
    {
      "name": "Wafik S. El-Deiry",
      "url": "https://patentbrief.org/inventor/wafik-s-el-deiry"
    },
    {
      "name": "Joshua E. Allen",
      "url": "https://patentbrief.org/inventor/joshua-e-allen"
    }
  ],
  "times_cited": 3,
  "tags": [
    "biotech",
    "pharmaceutical"
  ],
  "abstract": "Methods and compositions relating to TIC10 are described according to aspects of the present invention. The compositions and methods have utility in treating disease, particularly cancer in a subject in need thereof, including a human subject as well as subjects of other species. The compositions have utility in treating brain cancer in a subject in need thereof.",
  "url": "https://patentbrief.org/patent/us/RE46290/tecfidera-dimethyl-fumarate",
  "markdown_url": "https://patentbrief.org/patent/us/RE46290/tecfidera-dimethyl-fumarate/md",
  "google_patents_url": "https://patents.google.com/patent/USRE46290",
  "relatedPatents": []
}