{
  "patent_number": "US 9884123",
  "country": "US",
  "title": "Targeted Platinum Drugs for Cancer Treatment",
  "original_title": "Ligand-targeted molecules and methods thereof",
  "summary": "This patent describes a way to deliver platinum-based cancer drugs directly to tumor cells by attaching them to a special 'ligand' molecule that seeks out cancer cell markers.",
  "what_it_does": "This patent describes a 'ligand drug conjugate' (LDC) designed to deliver chemotherapy drugs specifically to cancer cells. The LDC works by connecting a 'ligand' (a molecule that can find and stick to specific targets) to a 'functional moiety,' which is then linked to a 'coordination metal complex' containing platinum (II). This platinum complex is, in turn, connected to a drug. The ligand is designed to bind to a 'protein, receptor, or cell marker on a surface of a cancer cell' (claims 2, 9), acting like a homing beacon. The connections between these parts are made by 'linkers,' which can be simple chains like hydrocarbons or more complex ones like polyethylene glycol (PEG), amino acids, or peptides (claims 3, 10). For example, a ligand might specifically recognize a unique protein found only on the surface of lung cancer cells, guiding the attached platinum drug directly to those cells to treat the cancer (claims 5, 11) while minimizing harm to healthy tissues.",
  "what_it_does_not_cover": [
    "Does not cover non-targeted platinum drugs that distribute throughout the body without a specific cancer cell homing mechanism.",
    "Does not cover targeted drug conjugates that use metal complexes other than platinum (II) as the central coordination component.",
    "Does not cover targeted drug conjugates where the drug is not connected via a platinum (II) coordination complex.",
    "Does not cover methods of treating diseases other than cancer using these specific conjugates.",
    "Does not cover targeting mechanisms that do not involve a ligand binding to a protein, receptor, or cell marker on a cancer cell's surface."
  ],
  "filed": "2013-01-03",
  "granted": "2018-02-06",
  "expires": "2033-01-03",
  "status": "active",
  "holder": "INVICTUS ONCOLOGY PVT",
  "holder_url": "https://patentbrief.org/company/invictus-oncology-pvt",
  "inventors": [
    {
      "name": "Sazid Hussain",
      "url": "https://patentbrief.org/inventor/sazid-hussain"
    },
    {
      "name": "Monideepa Roy",
      "url": "https://patentbrief.org/inventor/monideepa-roy"
    },
    {
      "name": "Dipankar Pramanik",
      "url": "https://patentbrief.org/inventor/dipankar-pramanik"
    },
    {
      "name": "Seikh Samad Hossain",
      "url": "https://patentbrief.org/inventor/seikh-samad-hossain"
    },
    {
      "name": "Shiladitya Sengupta",
      "url": "https://patentbrief.org/inventor/shiladitya-sengupta"
    }
  ],
  "times_cited": 3,
  "tags": [
    "biotech",
    "pharmaceutical",
    "oncology",
    "drug_delivery",
    "chemistry"
  ],
  "abstract": "The present invention relates to ligand-targeted molecules and ligand drug conjugates (LDCs) comprising a ligand connected to a functional group, which is connected to a linker, which in turn is bonded to a drug. The LDCs of the present invention also comprise platinum coordination complex wherein the platinum is connected to the linker through monocarboxylato and O→Pt coordinate bonds. The present invention also relates to methods for preparing these ligand drug conjugates. The present invention further relates to methods for the treatment of tumours using the ligand drug conjugates of the present invention.",
  "url": "https://patentbrief.org/patent/us/9884123/ligand-targeted-molecules-and-methods-thereof",
  "markdown_url": "https://patentbrief.org/patent/us/9884123/ligand-targeted-molecules-and-methods-thereof/md",
  "google_patents_url": "https://patents.google.com/patent/US9884123",
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}