# How Devices Precisely Track Glucose Across Body Compartments > This patent describes a method for accurately estimating a person's blood glucose by accounting for the natural time delay in how glucose moves between different body fluids, like blood and the fluid around cells, to better control insulin pumps. - **Patent:** US 9854998 - **Original title:** Method and/or system for multicompartment analyte monitoring - **Owner:** Medtronic Minimed - **Granted:** 2018 - **Status:** Active - **Times cited:** 1 - **Field:** biotech, medical_devices, software, consumer_electronics ## What it does This patent describes a method and system for more accurately monitoring an analyte, such as glucose (Claim 3), in a person's body. It uses a sensor (Claim 7) to measure the analyte in a 'second physiological compartment,' like interstitial fluid (Claim 3). A controller or processor (Claim 1, 7) then estimates the time delay, or 'latency,' for the analyte to move between this second compartment and a 'first physiological compartment,' such as blood plasma (Claim 3). This estimation relies on at least one blood glucose reference sample (Claim 1, 7). The system then 'compensates' for this latency when calculating the analyte's concentration in the first compartment. This compensation involves accumulating differences between sensor readings and an offset, and combining this with a term that includes the estimated latency (Claim 1). Based on this more accurate estimate, the controller generates commands for infusion pumps (Claim 1, 7), such as an insulin pump, to adjust treatment. For example, a continuous glucose monitor (CGM) measures glucose in interstitial fluid, and this patent helps the system predict the actual blood glucose level more precisely, even with the natural delay, to deliver the correct amount of insulin. ## What it does NOT cover - Does not cover glucose monitoring systems that do not actively estimate and compensate for the time delay (latency) between glucose levels in different body compartments. - Does not cover systems that only measure glucose in a single physiological compartment without considering the transport latency between two distinct compartments. - Does not cover glucose monitoring systems that only display readings without generating commands for an infusion pump based on the estimated concentration. - Does not cover systems that do not use at least one blood glucose reference sample to help estimate the latency. - Does not cover compensation methods that do not involve accumulating difference values between a sensor signal and an offset, and combining this with a term including the estimated latency. ## The clever bit The clever part is explicitly estimating and then mathematically compensating for the natural time lag (latency) of an analyte, like glucose, as it moves between different body fluids. This allows for more accurate real-time estimation of blood glucose from a sensor placed in a different body compartment, which is crucial for automated treatment decisions. ## Real-world examples 1. Medtronic MiniMed systems 2. Automated insulin delivery systems (artificial pancreas systems) 3. Continuous Glucose Monitoring (CGM) devices integrated with insulin pumps ## Why it matters Accurate glucose monitoring is critical for managing diabetes, especially for automated insulin delivery systems. The body's fluids, like blood and interstitial fluid, don't change glucose levels at the exact same time. This patent improves the precision of continuous glucose monitoring by accounting for these natural delays, leading to more timely and effective treatment decisions. This directly impacts patient safety and health outcomes by reducing the risk of dangerously high or low blood sugar. ## Frequently asked questions ### What does How Devices Precisely Track Glucose Across Body Compartments cover? This patent describes a method for accurately estimating a person's blood glucose by accounting for the natural time delay in how glucose moves between different body fluids, like blood and the fluid around cells, to better control insulin pumps. ### Who owns patent US 9854998? Medtronic Minimed owns this patent, granted in 2018. ### When does this patent expire? This patent is expected to expire on October 10, 2034, when the invention enters the public domain. ### What is patent US 9854998 cited by? This patent has been cited by 1 later patents that build on its ideas. ### What problem does this patent solve? Accurate glucose monitoring is critical for managing diabetes, especially for automated insulin delivery systems. The body's fluids, like blood and interstitial fluid, don't change glucose levels at the exact same time. This patent improves the precision of continuous glucose monitoring by accounting for these natural delays, leading to more timely and effective treatment decisions. This directly impacts patient safety and health outcomes by reducing the risk of dangerously high or low blood sugar. ### What does this patent NOT cover? Does not cover glucose monitoring systems that do not actively estimate and compensate for the time delay (latency) between glucose levels in different body compartments. **Full plain-English explainer:** https://patentbrief.org/patent/us/9854998/method-andor-system-for-multicompartment-analyte-monitoring **Original patent:** https://patents.google.com/patent/US9854998 --- _Source: PatentBrief — https://patentbrief.org. Patent facts are from public records; the plain-English explanation is PatentBrief's._ ## Related patents Semantically similar inventions in the PatentBrief corpus: - [How Continuous Glucose Monitors Estimate Blood Sugar Levels Accurately](https://patentbrief.org/patent/us/8882665/method-andor-system-for-multicompartment-analyte-monitoring-8882665) — This patent describes a method for accurately estimating blood glucose levels by accounting for the natural delay in glucose moving between interstitial fluid and blood, using sensor data and its rate of change. - [How a Sensor Checks Itself for Accuracy Using Other Body Data](https://patentbrief.org/patent/us/20230263439/systems-and-methods-for-multi-analyte-sensing) — This patent describes a smart system that uses additional body measurements or relationships between different body chemicals to figure out if an analyte sensor, like a glucose monitor, is giving wrong readings and then fixes it or tells you to replace it. - [How Glucose Sensors Check Their Own Reliability for Insulin Pumps](https://patentbrief.org/patent/us/9282925/systems-and-methods-for-replacing-signal-artifacts-in-a-glucose-sensor-data-stre) — This patent describes a system that automatically checks how trustworthy a continuous glucose sensor's readings are and then adjusts how an insulin pump delivers medicine based on that trust level. - [How a Computer System Automatically Adjusts Blood Sugar in Real-Time](https://patentbrief.org/patent/us/8956321/computerized-system-for-blood-chemistry-monitoring) — This patent describes a computerized system that continuously monitors a patient's blood glucose and automatically adjusts insulin and dextrose delivery to keep blood sugar levels stable, especially for critically ill patients. - [A Catheter That Measures Glucose While Delivering Medication](https://patentbrief.org/patent/us/11382539/analyte-sensor) — This patent describes a medical system that combines a catheter for delivering medication with a continuous glucose sensor built directly onto its surface, allowing for simultaneous monitoring and therapy.