{
  "patent_number": "US 9845355",
  "country": "US",
  "title": "How Genentech's Antibody Targets Cancerous B Cells",
  "original_title": "Humanized anti-CD79b antibodies and immunoconjugates and methods of use",
  "summary": "This patent describes a specific humanized antibody designed to bind to a protein called CD79b, which is found on the surface of certain cancer cells.",
  "what_it_does": "The patent claims a specific molecular structure for an antibody that targets the CD79b protein. Antibodies are Y-shaped proteins that the immune system uses to identify foreign objects. By defining precise amino acid sequences for the hypervariable regions (the parts of the antibody that 'grab' onto a target), this patent creates a highly specific key for the CD79b lock. When these antibodies bind to CD79b on the surface of B cells, they can be used to tag those cells for destruction, particularly in patients with B-cell cancers like lymphoma or leukemia.",
  "what_it_does_not_cover": [
    "Does not cover antibodies that use different amino acid sequences for the hypervariable regions defined in claim 1.",
    "Does not cover general methods for creating humanized antibodies that do not utilize the specific sequences listed.",
    "Does not cover targeting proteins other than CD79b.",
    "Does not cover the use of these antibodies for non-medical or non-diagnostic purposes."
  ],
  "filed": "2008-07-15",
  "granted": "2017-12-19",
  "expires": null,
  "status": "active",
  "holder": "Genentech Inc",
  "holder_url": "https://patentbrief.org/company/genentech-inc",
  "inventors": [
    {
      "name": "Mark Dennis",
      "url": "https://patentbrief.org/inventor/mark-dennis"
    },
    {
      "name": "Kristi Elkins",
      "url": "https://patentbrief.org/inventor/kristi-elkins"
    },
    {
      "name": "Jagath Reddy Junutula",
      "url": "https://patentbrief.org/inventor/jagath-reddy-junutula"
    },
    {
      "name": "Yvonne Chen",
      "url": "https://patentbrief.org/inventor/yvonne-chen"
    },
    {
      "name": "Bing Zheng",
      "url": "https://patentbrief.org/inventor/bing-zheng"
    },
    {
      "name": "Andrew Polson",
      "url": "https://patentbrief.org/inventor/andrew-polson"
    }
  ],
  "times_cited": 13,
  "tags": [
    "biotech",
    "pharmaceutical"
  ],
  "abstract": "The present invention is directed to anti-CD79b antibodies with specific hypervariable region sequences in the heavy and light chain variable domains as enumerated in the SEQ ID NOs described herein.",
  "url": "https://patentbrief.org/patent/us/9845355/tecentriq-atezolizumab",
  "markdown_url": "https://patentbrief.org/patent/us/9845355/tecentriq-atezolizumab/md",
  "google_patents_url": "https://patents.google.com/patent/US9845355",
  "relatedPatents": []
}