{
  "patent_number": "US 9481728",
  "country": "US",
  "title": "How Genetically Modified T-Cells Fight CD19 Cancers",
  "original_title": "Compositions and methods for treatment of cancer",
  "summary": "This patent describes how to create and use genetically modified human T cells that target and kill cancer cells expressing the CD19 protein, offering a new way to treat blood cancers.",
  "what_it_does": "This patent describes a specialized human cell, often a T cell, that has been genetically engineered to fight cancer. The cell contains a 'lentiviral vector' carrying instructions for a 'chimeric antigen receptor' (CAR). This CAR is designed with a 'CD19 antigen binding domain' (specifically, the amino acid sequence of SEQ ID NO: 20) to recognize a protein called CD19 found on certain cancer cells. It also includes a 'transmembrane domain' to anchor it, a 'costimulatory signaling region' with 4-1BB to boost the T cell's activity, and a 'CD3 zeta signaling domain' to trigger the cell to kill the cancer. For example, a patient with leukemia could have their own T cells modified with this CAR and then re-infused to target and destroy their CD19-expressing cancer cells.",
  "what_it_does_not_cover": [
    "Does not cover CAR T-cells that target other cancer-specific proteins besides CD19.",
    "Does not cover CAR T-cells that use different costimulatory signaling regions than 4-1BB.",
    "Does not cover CARs that lack a CD3 zeta signaling domain.",
    "Does not cover gene delivery methods other than lentiviral vectors.",
    "Does not cover treating solid tumors, as the claims focus on CD19-expressing cells and hematological cancers.",
    "Does not cover cells that are not derived from a human having cancer for treatment purposes."
  ],
  "filed": "2015-12-30",
  "granted": "2016-11-01",
  "expires": "2035-12-30",
  "status": "active",
  "holder": "University of Pennsylvania Penn",
  "holder_url": "https://patentbrief.org/company/university-of-pennsylvania-penn",
  "inventors": [
    {
      "name": "Michael D. Kalos",
      "url": "https://patentbrief.org/inventor/michael-d-kalos"
    },
    {
      "name": "Michael C. Milone",
      "url": "https://patentbrief.org/inventor/michael-c-milone"
    },
    {
      "name": "Bruce L. Levine",
      "url": "https://patentbrief.org/inventor/bruce-l-levine"
    },
    {
      "name": "Carl H. June",
      "url": "https://patentbrief.org/inventor/carl-h-june"
    },
    {
      "name": "David L. Porter",
      "url": "https://patentbrief.org/inventor/david-l-porter"
    }
  ],
  "times_cited": 37,
  "tags": [
    "biotech",
    "pharmaceutical",
    "gene_editing",
    "oncology"
  ],
  "abstract": "The present invention provides compositions and methods for treating cancer in a human. The invention includes relates to administering a genetically modified T cell to express a CAR wherein the CAR comprises an antigen binding domain, a transmembrane domain, a costimulatory signaling region, and a CD3 zeta signaling domain.",
  "url": "https://patentbrief.org/patent/us/9481728/compositions-and-methods-for-treatment-of-cancer",
  "markdown_url": "https://patentbrief.org/patent/us/9481728/compositions-and-methods-for-treatment-of-cancer/md",
  "google_patents_url": "https://patents.google.com/patent/US9481728",
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}