{
  "patent_number": "US 9402913",
  "country": "US",
  "title": "Combining Cyclosporine A and Steroids into a Single Hybrid Drug",
  "original_title": "Cyclosporine A steroid conjugates",
  "summary": "A chemical method for linking cyclosporine A and steroid molecules into a single hybrid drug designed to treat eye conditions by releasing both components upon contact.",
  "what_it_does": "This patent describes a molecular hybrid that physically links a cyclosporine A molecule to a steroid molecule using a chemical bridge called a linker. The goal is to create a single drug entity that can be applied topically to the eye. Once applied, the body's natural enzymes or moisture cause the linker to break, releasing the two active drugs simultaneously to provide a combined therapeutic effect.",
  "what_it_does_not_cover": [
    "Does not cover the individual use of cyclosporine A or steroids as separate, non-linked medications.",
    "Does not cover any random combination of drugs that are not specifically linked via the described chemical structures.",
    "Does not cover delivery systems that use physical mixtures of drugs rather than a single covalently bonded molecule."
  ],
  "filed": "2014-03-06",
  "granted": "2016-08-02",
  "expires": null,
  "status": "active",
  "holder": "Allergan Inc",
  "holder_url": "https://patentbrief.org/company/allergan-inc",
  "inventors": [
    {
      "name": "Liming Wang",
      "url": "https://patentbrief.org/inventor/liming-wang"
    },
    {
      "name": "Ken Chow",
      "url": "https://patentbrief.org/inventor/ken-chow"
    },
    {
      "name": "Santosh C. Sinha",
      "url": "https://patentbrief.org/inventor/santosh-c-sinha"
    },
    {
      "name": "Mayssa Attar",
      "url": "https://patentbrief.org/inventor/mayssa-attar"
    },
    {
      "name": "Brandon D. Swift",
      "url": "https://patentbrief.org/inventor/brandon-d-swift"
    },
    {
      "name": "Michael E. Garst",
      "url": "https://patentbrief.org/inventor/michael-e-garst"
    }
  ],
  "times_cited": 1,
  "tags": [
    "biotech",
    "pharmaceutical"
  ],
  "abstract": "The present invention describes Cyclosporine A/steroid hybrid analogs. These single drug entities are formed by connecting a steroid with Cyclosporine A. Upon topical application to the eye, the conjugate hybrid would undergo enzymatic and/or hydrolytic cleavage to release the individual drugs.",
  "url": "https://patentbrief.org/patent/us/9402913/sovaldi-sofosbuvir",
  "markdown_url": "https://patentbrief.org/patent/us/9402913/sovaldi-sofosbuvir/md",
  "google_patents_url": "https://patents.google.com/patent/US9402913",
  "relatedPatents": []
}