{
  "patent_number": "US 9370488",
  "country": "US",
  "title": "Making Insulin Last Longer with Tiny Coated Drug Particles",
  "original_title": "Method and system for synthesizing nanocarrier based long acting drug delivery system for insulin",
  "summary": "This patent describes how to create tiny, layered particles that can hold insulin and release it slowly into the body, aiming for longer-lasting diabetes treatment.",
  "what_it_does": "This patent details a method for creating nanoparticles designed to deliver insulin over an extended period. The core of these nanoparticles is an aqueous phase containing insulin, as described in claim 1. This core is surrounded by a lipid layer, which can be made from specific fats like palmitic acid or glyceryl stearate, and a phospholipid bilayer. Finally, a chitosan shell or coat encapsulates the entire structure. For example, a method outlined in claim 5 involves dissolving specific lipids and phospholipids in an organic solvent, then adding this mixture dropwise to an aqueous solution containing insulin. A chitosan solution is then added, causing the nanoparticles to form and trap the insulin inside, allowing for slow release after injection.",
  "what_it_does_not_cover": [
    "Does not cover insulin delivery systems that do not use a lipid/phospholipid core with an aqueous insulin phase and a chitosan shell.",
    "Does not cover nanoparticles with a zeta potential outside the range of 10 mv to 30 mv, or a peak size distribution not at 128.5 nm.",
    "Does not cover methods of synthesis that do not involve adding an organic solution of lipids dropwise to an aqueous insulin solution.",
    "Does not cover long-acting insulin formulations that are not based on entrapping insulin within nanoparticles.",
    "Does not cover nanoparticles where the lipid component is not selected from monostearyl glycerol, distearyl glycerol, palmitic acid, stearic acid, or glyceryl stearate."
  ],
  "filed": "2014-07-21",
  "granted": "2016-06-21",
  "expires": "2034-07-21",
  "status": "active",
  "holder": "Tehram",
  "holder_url": "https://patentbrief.org/company/tehram",
  "inventors": [
    {
      "name": "Mehrdad Hamidi",
      "url": "https://patentbrief.org/inventor/mehrdad-hamidi"
    }
  ],
  "times_cited": 0,
  "tags": [
    "pharmaceutical",
    "biotech",
    "materials",
    "healthcare"
  ],
  "abstract": "The embodiments herein provide a long-acting injectable drug (insulin) delivery nano-carrier system and a method of synthesizing the same. The insulin entrapped nanoparticles are prepared using a lipid/phospholipid core which is coated by a polymer. The lipid and phospholipid are dissolved in organic solvent. This solution is transferred into an aqueous phase consisting of distilled water or a buffer and dissolved insulin. A solution of polymer is added drop wise. The drug entrapped nanoparticle formation is achieved by diffusion of the organic solvent within the aqueous solvent to obtain the nanoparticles. The drug gets entrapped within the formed nanoparticles via the anti-solvency effect of the aqueous matrix. The resulting drug nanocarriers are capable of releasing the drug in a slow rate upon injection. The synthesized drug carrying nanoparticles are cryopreserved stored for future administration. For better storage the nanodispersion is dried to form a powder.",
  "url": "https://patentbrief.org/patent/us/9370488/method-and-system-for-synthesizing-nanocarrier-based-long-acting-drug-delivery-s",
  "markdown_url": "https://patentbrief.org/patent/us/9370488/method-and-system-for-synthesizing-nanocarrier-based-long-acting-drug-delivery-s/md",
  "google_patents_url": "https://patents.google.com/patent/US9370488",
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}