{
  "patent_number": "US 9266948",
  "country": "US",
  "title": "How Genentech Engineered Antibodies to Block the Bv8 Protein",
  "original_title": "Anti-Bv8 antibodies and uses thereof",
  "summary": "This patent details specific genetic blueprints for creating antibodies that target and neutralize Bv8, a protein often associated with tumor growth and inflammation.",
  "what_it_does": "The patent claims the specific genetic sequences (nucleic acids) required to manufacture antibodies that bind to the Bv8 protein. These antibodies work by attaching to the Bv8 molecule, effectively neutralizing its ability to interact with its receptors in the body. By defining the exact amino acid sequences for the six hypervariable regions (HVRs)—the parts of the antibody that act like a lock to the protein's key—the patent provides a precise recipe for creating these therapeutic molecules. These sequences are then packaged into vectors and host cells, which act as biological factories to produce the antibodies at scale.",
  "what_it_does_not_cover": [
    "Does not cover antibodies that bind to proteins other than Bv8.",
    "Does not cover the clinical use or medical treatment methods for patients using these antibodies.",
    "Does not cover antibodies with hypervariable region sequences that deviate from the specific amino acid patterns defined in the claims.",
    "Does not cover the Bv8 protein itself, only the synthetic antibodies designed to bind to it."
  ],
  "filed": "2014-05-29",
  "granted": "2016-02-23",
  "expires": null,
  "status": "active",
  "holder": "Genentech Inc",
  "holder_url": "https://patentbrief.org/company/genentech-inc",
  "inventors": [
    {
      "name": "Napoleone Ferrara",
      "url": "https://patentbrief.org/inventor/napoleone-ferrara"
    },
    {
      "name": "Yu-Ju G. Meng",
      "url": "https://patentbrief.org/inventor/yu-ju-g-meng"
    },
    {
      "name": "Lanlan Yu",
      "url": "https://patentbrief.org/inventor/lanlan-yu"
    },
    {
      "name": "Van Wu",
      "url": "https://patentbrief.org/inventor/van-wu"
    },
    {
      "name": "Janet Tien",
      "url": "https://patentbrief.org/inventor/janet-tien"
    },
    {
      "name": "Xiumin Wu",
      "url": "https://patentbrief.org/inventor/xiumin-wu"
    },
    {
      "name": "Wei-Ghing Liang",
      "url": "https://patentbrief.org/inventor/wei-ghing-liang"
    }
  ],
  "times_cited": 0,
  "tags": [
    "biotech",
    "pharmaceutical"
  ],
  "abstract": "The present invention concerns antibodies to Bv8 and the uses of same.",
  "url": "https://patentbrief.org/patent/us/9266948/kadcyla-t-dm1",
  "markdown_url": "https://patentbrief.org/patent/us/9266948/kadcyla-t-dm1/md",
  "google_patents_url": "https://patents.google.com/patent/US9266948",
  "relatedPatents": []
}