{
  "patent_number": "US 9216996",
  "country": "US",
  "title": "Gilead's Chemical Compounds for Treating HIV Infections",
  "original_title": "Substituted 2,3,4,5,7,9,13,13a-octahydropyrido[1′,2′:4,5]pyrazino[2,1-b][1,3]oxazepines and methods for treating viral infections",
  "summary": "This patent covers specific chemical structures designed to block HIV from replicating in human cells, providing a foundation for new antiviral medications.",
  "what_it_does": "This patent claims specific chemical structures known as substituted octahydropyrido-pyrazino-oxazepines. These molecules act as inhibitors, which means they are designed to bind to viral proteins to stop the HIV virus from completing its life cycle. By preventing the virus from integrating its genetic material into the host cell, these compounds help reduce the viral load in a patient. The patent also covers the pharmaceutical formulations, such as pills or liquids, that combine these active chemical compounds with carriers or diluents for safe delivery into the body.",
  "what_it_does_not_cover": [
    "Does not cover general classes of HIV drugs like protease inhibitors or reverse transcriptase inhibitors.",
    "Does not cover the biological process of HIV infection itself.",
    "Does not cover other chemical structures that fall outside the specific formula defined in the claims.",
    "Does not cover methods of manufacturing the chemical precursors used to synthesize these compounds."
  ],
  "filed": "2013-12-19",
  "granted": "2015-12-22",
  "expires": null,
  "status": "active",
  "holder": "Gilead Sciences Inc",
  "holder_url": "https://patentbrief.org/company/gilead-sciences-inc",
  "inventors": [
    {
      "name": "Haolun Jin",
      "url": "https://patentbrief.org/inventor/haolun-jin"
    },
    {
      "name": "Scott E. Lazerwith",
      "url": "https://patentbrief.org/inventor/scott-e-lazerwith"
    },
    {
      "name": "Hyung-Jung Pyun",
      "url": "https://patentbrief.org/inventor/hyung-jung-pyun"
    }
  ],
  "times_cited": 35,
  "tags": [
    "biotech",
    "pharmaceutical"
  ],
  "abstract": "Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R 1 , X, W, Y 1 , Y 2 , Z 1 , and Z 4 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.",
  "url": "https://patentbrief.org/patent/us/9216996/genvoya-elvitegravir-cobicistat-taf-ftc",
  "markdown_url": "https://patentbrief.org/patent/us/9216996/genvoya-elvitegravir-cobicistat-taf-ftc/md",
  "google_patents_url": "https://patents.google.com/patent/US9216996",
  "relatedPatents": []
}