{
  "patent_number": "US 9011851",
  "country": "US",
  "title": "Using Antibodies to Block HER3 Proteins in Cancer Cells",
  "original_title": "Inhibitors of her3 activity",
  "summary": "A patent describing specific antibodies that bind to and block the HER3 protein, which is often used by cancer cells to grow and survive.",
  "what_it_does": "This patent identifies specific antibodies, named 1B4C3 and 2D1D12, that target the HER3 protein. HER3 is a receptor on the surface of cells that, when activated, sends signals that can cause cells to multiply uncontrollably. By binding to HER3, these antibodies prevent the protein from sending those growth signals. The patent claims the use of these antibodies as a pharmaceutical composition to treat hyperproliferative diseases, such as tumors, often in combination with other cancer-fighting drugs.",
  "what_it_does_not_cover": [
    "Does not cover general methods of inhibiting HER3 that do not use the specific 1B4C3 or 2D1D12 antibodies.",
    "Does not cover antibodies that lack the specific six CDR sequences defined for 1B4C3.",
    "Does not cover the use of small-molecule drugs that inhibit HER3 activity through mechanisms other than antibody binding.",
    "Does not cover treatments for diseases that are not related to hyperproliferative cell growth."
  ],
  "filed": "2002-08-09",
  "granted": "2015-04-21",
  "expires": null,
  "status": "active",
  "holder": "Max Planck Gesellschaft zur Foerderung der Wissenschaften eV",
  "holder_url": "https://patentbrief.org/company/max-planck-gesellschaft-zur-foerderung-der-wissenschaften-ev",
  "inventors": [
    {
      "name": "Axel Ullrich",
      "url": "https://patentbrief.org/inventor/axel-ullrich"
    },
    {
      "name": "Edward Htun-van der Horst",
      "url": "https://patentbrief.org/inventor/edward-htun-van-der-horst"
    }
  ],
  "times_cited": 5,
  "tags": [
    "biotech",
    "pharmaceutical"
  ],
  "abstract": "The present invention relates to a pharmaceutical composition comprising as an active agent an inhibitor of HER3 activity, particularly an anti-HER3-antibody. Further, the use of this composition for the diagnosis, prevention or treatment of hyperproliferative diseases, particularly tumor diseases is disclosed.",
  "url": "https://patentbrief.org/patent/us/9011851/perjeta-pertuzumab",
  "markdown_url": "https://patentbrief.org/patent/us/9011851/perjeta-pertuzumab/md",
  "google_patents_url": "https://patents.google.com/patent/US9011851",
  "relatedPatents": []
}