{
  "patent_number": "US 8735372",
  "country": "US",
  "title": "Treating Hepatitis C with Combination Drug Therapy",
  "original_title": "Nucleoside phosphoramidate prodrugs",
  "summary": "A Gilead Sciences patent detailing a method to treat Hepatitis C by combining a specific chemical compound with an NS5a inhibitor.",
  "what_it_does": "This patent describes a medical treatment for Hepatitis C that uses a two-part drug strategy. It requires the administration of an NS5a inhibitor alongside a specific type of chemical compound known as a nucleoside phosphoramidate prodrug. The patent defines the precise molecular structure of this prodrug, including various side chains and chemical groups that allow the drug to be effective. By combining these two distinct types of inhibitors, the treatment aims to disrupt the Hepatitis C virus's ability to replicate in the human body.",
  "what_it_does_not_cover": [
    "Does not cover the use of the phosphoramidate prodrugs as a standalone treatment.",
    "Does not cover chemical structures that fall outside the specific R1, R2, R3, R4, R7, and R8 substituent definitions provided.",
    "Does not cover treatments for viral infections other than Hepatitis C.",
    "Does not cover the synthesis of the NS5a inhibitor itself."
  ],
  "filed": "2013-10-18",
  "granted": "2014-05-27",
  "expires": null,
  "status": "active",
  "holder": "Gilead Pharmasset LLC",
  "holder_url": "https://patentbrief.org/company/gilead-pharmasset-llc",
  "inventors": [
    {
      "name": "Michael Joseph Sofia",
      "url": "https://patentbrief.org/inventor/michael-joseph-sofia"
    },
    {
      "name": "Dhanapalan Nagarathnam",
      "url": "https://patentbrief.org/inventor/dhanapalan-nagarathnam"
    },
    {
      "name": "Peiyuan Wang",
      "url": "https://patentbrief.org/inventor/peiyuan-wang"
    },
    {
      "name": "Jinfa Du",
      "url": "https://patentbrief.org/inventor/jinfa-du"
    }
  ],
  "times_cited": 42,
  "tags": [
    "biotech",
    "pharmaceutical"
  ],
  "abstract": "Disclosed herein are phosphoramidate prodrugs of nucleoside derivatives for the treatment of viral infections in mammals, which is a compound, its stereoisomer, salt (acid or basic addition salt), hydrate, solvate, or crystalline form thereof, represented by the following structure: Also disclosed are methods of treatment, uses, and processes for preparing each of which utilize the compound represented by formula I.",
  "url": "https://patentbrief.org/patent/us/8735372/sovaldi-sofosbuvir-composition",
  "markdown_url": "https://patentbrief.org/patent/us/8735372/sovaldi-sofosbuvir-composition/md",
  "google_patents_url": "https://patents.google.com/patent/US8735372",
  "relatedPatents": []
}