{
  "patent_number": "US 8710041",
  "country": "US",
  "title": "Using Purified Fish Oil Derivatives to Lower Triglycerides Alongside Statins",
  "original_title": "Compositions and methods for lowering triglycerides in a subject on concomitant statin therapy",
  "summary": "A medical treatment method using a specific high-dose, purified EPA supplement to lower triglycerides in patients already taking statin medication.",
  "what_it_does": "This patent describes a method for treating patients who are already taking statins but still have elevated triglyceride levels between 200 and 500 mg/dl. The treatment involves a daily 4-gram dose of ethyl-EPA, a highly purified form of an omega-3 fatty acid. Crucially, the composition must contain no more than 4% DHA, another common omega-3, to ensure the specific therapeutic effect. By administering this for at least four weeks, the method aims to reduce triglycerides by at least 15% while also lowering LDL-C (bad cholesterol) and VLDL-C levels compared to patients taking statins alone.",
  "what_it_does_not_cover": [
    "Does not cover compositions containing more than 4% DHA by weight of total fatty acids.",
    "Does not cover treatments for patients with triglyceride levels below 200 mg/dl or above 500 mg/dl.",
    "Does not cover the use of standard, non-purified fish oil supplements that include high levels of DHA.",
    "Does not cover methods involving non-oral administration routes."
  ],
  "filed": "2012-02-23",
  "granted": "2014-04-29",
  "expires": null,
  "status": "active",
  "holder": "Amarin Pharmaceuticals Ireland Ltd",
  "holder_url": "https://patentbrief.org/company/amarin-pharmaceuticals-ireland-ltd",
  "inventors": [
    {
      "name": "Mehar Manku",
      "url": "https://patentbrief.org/inventor/mehar-manku"
    },
    {
      "name": "Rene Braeckman",
      "url": "https://patentbrief.org/inventor/rene-braeckman"
    },
    {
      "name": "Ian Osterloh",
      "url": "https://patentbrief.org/inventor/ian-osterloh"
    },
    {
      "name": "Paresh Soni",
      "url": "https://patentbrief.org/inventor/paresh-soni"
    },
    {
      "name": "Pierre Wicker",
      "url": "https://patentbrief.org/inventor/pierre-wicker"
    }
  ],
  "times_cited": 13,
  "tags": [
    "pharmaceutical",
    "biotech"
  ],
  "abstract": "In various embodiments, the present invention provides compositions and methods for treating and/or preventing cardiovascular-related diseases in subject in need thereof.",
  "url": "https://patentbrief.org/patent/us/8710041/imbruvica-ibrutinib-formulation",
  "markdown_url": "https://patentbrief.org/patent/us/8710041/imbruvica-ibrutinib-formulation/md",
  "google_patents_url": "https://patents.google.com/patent/US8710041",
  "relatedPatents": []
}