{
  "patent_number": "US 8410274",
  "country": "US",
  "title": "Making Ivacaftor Easier for the Body to Absorb",
  "original_title": "Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide",
  "summary": "A patent describing a specific way to turn a drug molecule into an amorphous solid to help the body absorb it more effectively.",
  "what_it_does": "This patent describes how to create a solid dispersion of a drug molecule, specifically the compound known as Ivacaftor. In its natural state, this molecule is crystalline, which makes it hard for the human body to dissolve and absorb. By creating an amorphous solid dispersion—where the drug is mixed into a polymer matrix like HPMCAS—the molecules are locked in a disordered state that dissolves much faster in the gut. The patent specifically claims combinations of this drug with polymers and surfactants, often prepared through a process called spray drying.",
  "what_it_does_not_cover": [
    "Does not cover the chemical structure of the drug molecule itself.",
    "Does not cover crystalline forms of the drug.",
    "Does not cover methods of treating specific diseases like cystic fibrosis.",
    "Does not cover drug delivery methods that do not use solid dispersions."
  ],
  "filed": "2012-01-26",
  "granted": "2013-04-02",
  "expires": null,
  "status": "active",
  "holder": "Vertex Pharmaceuticals Inc",
  "holder_url": "https://patentbrief.org/company/vertex-pharmaceuticals-inc",
  "inventors": [
    {
      "name": "Yushi Feng",
      "url": "https://patentbrief.org/inventor/yushi-feng"
    },
    {
      "name": "William Rowe",
      "url": "https://patentbrief.org/inventor/william-rowe"
    },
    {
      "name": "Yuchuan Gong",
      "url": "https://patentbrief.org/inventor/yuchuan-gong"
    },
    {
      "name": "Patrick R. Connelly",
      "url": "https://patentbrief.org/inventor/patrick-r-connelly"
    },
    {
      "name": "Patricia Hurter",
      "url": "https://patentbrief.org/inventor/patricia-hurter"
    },
    {
      "name": "Adriana Costache",
      "url": "https://patentbrief.org/inventor/adriana-costache"
    },
    {
      "name": "Martin Trudeau",
      "url": "https://patentbrief.org/inventor/martin-trudeau"
    },
    {
      "name": "Christopher Ryan Young",
      "url": "https://patentbrief.org/inventor/christopher-ryan-young"
    },
    {
      "name": "Mariusz Krawiec",
      "url": "https://patentbrief.org/inventor/mariusz-krawiec"
    }
  ],
  "times_cited": 50,
  "tags": [
    "biotech",
    "pharmaceutical"
  ],
  "abstract": "The present invention relates to solid state forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1), pharmaceutical compositions thereof and methods therewith.",
  "url": "https://patentbrief.org/patent/us/8410274/kalydeco-ivacaftor",
  "markdown_url": "https://patentbrief.org/patent/us/8410274/kalydeco-ivacaftor/md",
  "google_patents_url": "https://patents.google.com/patent/US8410274",
  "relatedPatents": []
}