{
  "patent_number": "US 8216583",
  "country": "US",
  "title": "How to Keep Humira Stable in a Liquid Medicine Bottle",
  "original_title": "Formulation of human antibodies for treating TNF-α associated disorders",
  "summary": "A recipe for a stable, liquid version of the drug Humira that stays effective at high concentrations without spoiling or clumping.",
  "what_it_does": "This patent describes a specific chemical mixture that keeps a powerful antibody drug, known as D2E7 (Humira), stable in liquid form. Because antibodies are fragile proteins, they often clump together or break down when stored in water. The inventors created a precise buffer system using citrate and phosphate, combined with mannitol (a sugar alcohol) and polysorbate 80 (a surfactant), to protect the antibody at high concentrations. This allows the medicine to be injected easily without the need for the patient to mix a powder with liquid beforehand.",
  "what_it_does_not_cover": [
    "Does not cover the antibody D2E7 itself, only this specific liquid formulation.",
    "Does not cover formulations that use different buffer systems, such as those using only acetate or histidine.",
    "Does not cover freeze-dried or solid powder versions of the medication.",
    "Does not cover antibody concentrations outside the specified 20-150 mg/ml range."
  ],
  "filed": "2003-08-15",
  "granted": "2012-07-10",
  "expires": null,
  "status": "active",
  "holder": "Abbott Biotech Ltd Bermuda",
  "holder_url": "https://patentbrief.org/company/abbott-biotech-ltd-bermuda",
  "inventors": [
    {
      "name": "Lisa Baust",
      "url": "https://patentbrief.org/inventor/lisa-baust"
    },
    {
      "name": "Hans-Juergen Kruase",
      "url": "https://patentbrief.org/inventor/hans-juergen-kruase"
    },
    {
      "name": "Michael Dickes",
      "url": "https://patentbrief.org/inventor/michael-dickes"
    }
  ],
  "times_cited": 58,
  "tags": [
    "biotech",
    "pharmaceutical"
  ],
  "abstract": "A liquid aqueous pharmaceutical formulation is described which has a high protein concentration, a pH of between about 4 and about 8, and enhanced stability.",
  "url": "https://patentbrief.org/patent/us/8216583/humira-dosing-regimen",
  "markdown_url": "https://patentbrief.org/patent/us/8216583/humira-dosing-regimen/md",
  "google_patents_url": "https://patents.google.com/patent/US8216583",
  "relatedPatents": []
}