{
  "patent_number": "US 7993644",
  "country": "US",
  "title": "Using Antibodies to Target Tissue Factor Without Stopping Blood Clotting",
  "original_title": "Tissue factor antibodies and uses thereof",
  "summary": "A patent describing specific antibodies that attach to a protein called tissue factor without interfering with the body's natural blood-clotting process.",
  "what_it_does": "This patent identifies specific antibodies that bind to human tissue factor, a protein often found in high amounts on cancer cells. Unlike many other antibodies that might block tissue factor, these are specifically selected because they do not inhibit blood coagulation, which is vital for patient safety. The patent covers the specific hybridoma cell lines (TF260, TF196, etc.) that produce these antibodies. It also details how these antibodies can be linked to cytotoxic agents—essentially toxic drugs—to deliver them directly to cells expressing tissue factor, or to detectable agents for imaging purposes.",
  "what_it_does_not_cover": [
    "Does not cover antibodies that inhibit or block the normal blood coagulation process.",
    "Does not cover general methods for creating antibodies that are not derived from the specific deposited hybridoma lines.",
    "Does not cover the use of tissue factor antibodies for purposes other than binding to the protein without affecting clotting."
  ],
  "filed": "2008-08-07",
  "granted": "2011-08-09",
  "expires": null,
  "status": "active",
  "holder": "Purdue Pharma LP",
  "holder_url": "https://patentbrief.org/company/purdue-pharma-lp",
  "inventors": [
    {
      "name": "Baiyang Wang",
      "url": "https://patentbrief.org/inventor/baiyang-wang"
    }
  ],
  "times_cited": 3,
  "tags": [
    "biotech",
    "pharmaceutical"
  ],
  "abstract": "The present invention provides antibodies capable of binding to human tissue factor, which do not inhibit tissue factor mediated blood coagulation compared to a normal plasma control. Further described are methods of making and methods of using the antibodies of the invention.",
  "url": "https://patentbrief.org/patent/us/7993644/stelara-ustekinumab",
  "markdown_url": "https://patentbrief.org/patent/us/7993644/stelara-ustekinumab/md",
  "google_patents_url": "https://patents.google.com/patent/US7993644",
  "relatedPatents": []
}