{
  "patent_number": "US 7807153",
  "country": "US",
  "title": "How Antibodies Can Force Cancer Cells to Self-Destruct",
  "original_title": "Apo-2 receptor agonist antibodies",
  "summary": "Genentech's patent on specific antibodies that bind to the Apo-2 receptor to trigger programmed cell death in cancer cells.",
  "what_it_does": "This patent describes monoclonal antibodies designed to target and bind to a specific protein called Apo-2, which is found on the surface of certain cells. When these antibodies attach to the Apo-2 receptor, they act as agonists, meaning they trigger a signal inside the cell that forces it to undergo apoptosis, or programmed cell death. By specifically targeting cancer cells that express this receptor, the antibodies can cause the tumor cells to kill themselves without necessarily harming healthy cells. For example, the patent demonstrates this effect in SK-MES-1 lung carcinoma cells.",
  "what_it_does_not_cover": [
    "Does not cover antibodies that bind to receptors other than Apo-2.",
    "Does not cover antibodies that block or inhibit apoptosis rather than triggering it.",
    "Does not cover small molecule drugs or chemical compounds that are not antibodies.",
    "Does not cover general methods of cancer treatment that do not use these specific agonist antibodies."
  ],
  "filed": "2003-04-25",
  "granted": "2010-10-05",
  "expires": null,
  "status": "active",
  "holder": "Genentech Inc",
  "holder_url": "https://patentbrief.org/company/genentech-inc",
  "inventors": [
    {
      "name": "Camellia W. Adams",
      "url": "https://patentbrief.org/inventor/camellia-w-adams"
    },
    {
      "name": "Avi J. Ashkenazi",
      "url": "https://patentbrief.org/inventor/avi-j-ashkenazi"
    },
    {
      "name": "Kyung Jin Kim",
      "url": "https://patentbrief.org/inventor/kyung-jin-kim"
    },
    {
      "name": "Anan Chuntharapai",
      "url": "https://patentbrief.org/inventor/anan-chuntharapai"
    }
  ],
  "times_cited": 2,
  "tags": [
    "biotech",
    "pharmaceutical"
  ],
  "abstract": "Novel polypeptides, designated Apo-2, which are capable of modulating apoptosis are provided. Compositions including Apo-2 chimeras, nucleic acid encoding Apo-2, and antibodies to Apo-2 are also provided.",
  "url": "https://patentbrief.org/patent/us/7807153/avastin-chemotherapy",
  "markdown_url": "https://patentbrief.org/patent/us/7807153/avastin-chemotherapy/md",
  "google_patents_url": "https://patents.google.com/patent/US7807153",
  "relatedPatents": []
}