{
  "patent_number": "US 7740842",
  "country": "US",
  "title": "How to Keep High-Concentration Antibody Medicines Stable in Liquid Form",
  "original_title": "Stable liquid formulations of antibodies",
  "summary": "Novartis's patent describes a specific liquid recipe for keeping high concentrations of E25 anti-IgE antibodies stable and usable for medical injections.",
  "what_it_does": "This patent details a way to create a stable liquid solution containing a high concentration (at least 80 mg/ml) of E25 anti-IgE antibodies. The core of the invention is using acetic acid as a stabilizing agent to prevent the antibodies from clumping together or degrading over time. By maintaining the solution within a specific pH range and avoiding certain salts like sodium acetate, the formulation remains effective for storage. This allows for smaller injection volumes, which is critical for patient comfort when delivering high doses of therapeutic proteins.",
  "what_it_does_not_cover": [
    "Does not cover antibody formulations that use sodium acetate as a buffer.",
    "Does not cover liquid formulations containing antibody types other than E25 anti-IgE.",
    "Does not cover solutions where the antibody concentration is below 80 mg/ml.",
    "Does not cover dry or lyophilized (freeze-dried) antibody powders."
  ],
  "filed": "2002-05-31",
  "granted": "2010-06-22",
  "expires": null,
  "status": "active",
  "holder": "Novartis AG",
  "holder_url": "https://patentbrief.org/company/novartis-ag",
  "inventors": [
    {
      "name": "Pierre F Fauquex",
      "url": "https://patentbrief.org/inventor/pierre-f-fauquex"
    },
    {
      "name": "Tudor Arvinte",
      "url": "https://patentbrief.org/inventor/tudor-arvinte"
    }
  ],
  "times_cited": 17,
  "tags": [
    "biotech",
    "pharmaceutical"
  ],
  "abstract": "The present invention provides stable liquid formulations of antibodies suitable for parenteral administration. Also, provided are aqueous solutions which have high concentrations of therapeutical antibodies which may be used to produce therapeutical liquid formulations. The present invention also relates to uses, such as medical uses, of the stable liquid formulations and processes for the production of the stable liquid formulations.",
  "url": "https://patentbrief.org/patent/us/7740842/herceptin-adjuvant-therapy",
  "markdown_url": "https://patentbrief.org/patent/us/7740842/herceptin-adjuvant-therapy/md",
  "google_patents_url": "https://patents.google.com/patent/US7740842",
  "relatedPatents": []
}