{
  "patent_number": "US 7528115",
  "country": "US",
  "title": "Improving Drug Delivery with Chemical Masks for Thiazolo-Pyrimidine Compounds",
  "original_title": "Carbonate and carbamate prodrugs of thiazolo[4,5-d]pyrimidines",
  "summary": "A patent describing modified chemical structures that act as dormant precursors, designed to be activated by the body to help treat viral infections like Hepatitis C.",
  "what_it_does": "The patent claims a specific class of chemical compounds known as prodrugs. These are essentially inactive versions of a drug that are chemically masked with carbonate or carbamate groups. Once a patient ingests the compound, the body's natural metabolic processes strip away these masks, releasing the active medicine exactly where and when it is needed. This chemical modification is intended to improve how well the drug is absorbed or how stable it remains in the bloodstream before reaching its target.",
  "what_it_does_not_cover": [
    "Does not cover the original, unprotected parent drug molecule itself.",
    "Does not cover general chemical synthesis methods for creating thiazolo-pyrimidines.",
    "Does not cover treatments for diseases other than those specifically mentioned, such as cancer or Hepatitis C."
  ],
  "filed": "2007-07-17",
  "granted": "2009-05-05",
  "expires": null,
  "status": "active",
  "holder": "Anadys Pharmaceuticals Inc",
  "holder_url": "https://patentbrief.org/company/anadys-pharmaceuticals-inc",
  "inventors": [
    {
      "name": "Gregory J. Haley",
      "url": "https://patentbrief.org/inventor/gregory-j-haley"
    },
    {
      "name": "Alan X. Xiang",
      "url": "https://patentbrief.org/inventor/alan-x-xiang"
    },
    {
      "name": "Joseph R. Lennox",
      "url": "https://patentbrief.org/inventor/joseph-r-lennox"
    },
    {
      "name": "Stephen E. Webber",
      "url": "https://patentbrief.org/inventor/stephen-e-webber"
    }
  ],
  "times_cited": 1,
  "tags": [
    "biotech",
    "pharmaceutical"
  ],
  "abstract": "The invention is directed to carbonate and carbamate prodrugs of thiazolo[4,5-d]pyrimidine compounds, whose metabolized parent compound has immunomodulatory activity. The invention also relates to the therapeutic use of such prodrugs and pharmaceutical compositions thereof in treating disease states associated with abnormal cell growth, such as cancer.",
  "url": "https://patentbrief.org/patent/us/7528115/eylea-aflibercept",
  "markdown_url": "https://patentbrief.org/patent/us/7528115/eylea-aflibercept/md",
  "google_patents_url": "https://patents.google.com/patent/US7528115",
  "relatedPatents": []
}