{
  "patent_number": "US 7387788",
  "country": "US",
  "title": "A Gel That Helps Nicotine Absorb Through Your Skin",
  "original_title": "Pharmaceutical compositions of nicotine and methods of use thereof",
  "summary": "A specialized gel formula designed to help nicotine pass through the skin or mouth lining without crystallizing or rubbing off on clothes.",
  "what_it_does": "This patent describes a gel that delivers nicotine through the skin or mucosal surfaces. It uses a specific solvent system containing a mixture of water, alcohol, a monoalkyl ether of diethylene glycol, and a glycol. By keeping these ingredients in precise ratios, the gel prevents the nicotine from crystallizing on the skin surface, which helps it absorb more effectively. It also reduces the chance of the medicine rubbing off onto clothing or other people.",
  "what_it_does_not_cover": [
    "Does not cover solid nicotine patches that use an adhesive backing to stay on the skin",
    "Does not cover nicotine delivery systems that rely on inhalation or combustion",
    "Does not cover formulations that lack the specific ratio of diethylene glycol ether to glycol",
    "Does not cover occlusive delivery systems that seal the skin off from the air"
  ],
  "filed": "2006-07-24",
  "granted": "2008-06-17",
  "expires": null,
  "status": "active",
  "holder": "Antares Pharma IPL AG",
  "holder_url": "https://patentbrief.org/company/antares-pharma-ipl-ag",
  "inventors": [
    {
      "name": "Arnaud Grenier",
      "url": "https://patentbrief.org/inventor/arnaud-grenier"
    },
    {
      "name": "R. Dario Norberto Carrara",
      "url": "https://patentbrief.org/inventor/r-dario-norberto-carrara"
    },
    {
      "name": "Celine Besse",
      "url": "https://patentbrief.org/inventor/celine-besse"
    }
  ],
  "times_cited": 25,
  "tags": [
    "pharmaceutical",
    "biotech"
  ],
  "abstract": "The present invention comprises non occlusive compositions for transdermal delivery of nicotine, and more particularly pharmaceutically acceptable salts thereof, and methods of making same. The composition may, for example, be a gel suitable for transdermal or transmucosal applications. The compositions of the present invention typically comprise a mixture of water and alcohol, and a solvent system having a mono alkyl ether of diethylene glycol and a glycol present in specified ratios and in specific amounts, wherein the pH of the gel is usually between a pH of 5.5 and 7. The compositions may include further components, for example, the hydroalcoholic vehicle may further comprise additional penetration enhancer(s), buffering agent(s), antioxidant(s), stabilizer(s) and/or gelling agent(s). The invention also relates to a method for the sustained delivery of nicotine pharmaceutically acceptable salts to treat a variety of conditions and disorders.",
  "url": "https://patentbrief.org/patent/us/7387788/soliris-eculizumab",
  "markdown_url": "https://patentbrief.org/patent/us/7387788/soliris-eculizumab/md",
  "google_patents_url": "https://patents.google.com/patent/US7387788",
  "relatedPatents": []
}