{
  "patent_number": "US 7070775",
  "country": "US",
  "title": "How Engineered Antibodies Block Inflammation-Causing Proteins",
  "original_title": "Recombinant A2-specific TNFα specific antibodies",
  "summary": "A patent describing lab-made antibodies designed to hunt down and neutralize a specific protein called TNF-alpha that causes chronic inflammation in the body.",
  "what_it_does": "This patent covers specific recombinant antibodies engineered to bind to human tumor necrosis factor-alpha (TNF-alpha). TNF-alpha is a protein that acts like an alarm bell for the immune system, but when it stays on too long, it causes diseases like rheumatoid arthritis or Crohn's. The patent claims antibodies that mimic the binding behavior of a specific reference antibody called A2. By attaching to TNF-alpha, these antibodies prevent the protein from triggering the inflammatory response in cells. The claims specify that these antibodies must have a human constant region to be better tolerated by the human immune system and must meet a high threshold of binding strength, measured by a Scatchard analysis.",
  "what_it_does_not_cover": [
    "Does not cover antibodies that bind to TNF-alpha but do not compete with the A2 reference antibody.",
    "Does not cover natural, non-recombinant antibodies found in living organisms.",
    "Does not cover therapeutic methods that use small molecule drugs instead of antibody-based proteins.",
    "Does not cover antibodies that fail to meet the specific binding affinity threshold of 1x10^8 liter/mole."
  ],
  "filed": "2002-07-18",
  "granted": "2006-07-04",
  "expires": null,
  "status": "active",
  "holder": "Centocor Inc",
  "holder_url": "https://patentbrief.org/company/centocor-inc",
  "inventors": [
    {
      "name": "Peter Daddona",
      "url": "https://patentbrief.org/inventor/peter-daddona"
    },
    {
      "name": "Junming Le",
      "url": "https://patentbrief.org/inventor/junming-le"
    },
    {
      "name": "Jan Vilcek",
      "url": "https://patentbrief.org/inventor/jan-vilcek"
    },
    {
      "name": "John Ghrayeb",
      "url": "https://patentbrief.org/inventor/john-ghrayeb"
    },
    {
      "name": "David Knight",
      "url": "https://patentbrief.org/inventor/david-knight"
    },
    {
      "name": "Scott Siegel",
      "url": "https://patentbrief.org/inventor/scott-siegel"
    }
  ],
  "times_cited": 77,
  "tags": [
    "biotech",
    "pharmaceutical"
  ],
  "abstract": "Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.",
  "url": "https://patentbrief.org/patent/us/7070775/humira-formulation",
  "markdown_url": "https://patentbrief.org/patent/us/7070775/humira-formulation/md",
  "google_patents_url": "https://patents.google.com/patent/US7070775",
  "relatedPatents": []
}