{
  "patent_number": "US 6824780",
  "country": "US",
  "title": "How Genentech Created Antibodies to Target Prostate Cancer Cells",
  "original_title": "Anti-tumor antibody compositions and methods of use",
  "summary": "A patent describing specific antibodies that latch onto and kill cancer cells expressing the PSCA protein, effectively turning the body's immune-targeting tools into cancer-fighting weapons.",
  "what_it_does": "This patent covers specific monoclonal antibodies designed to bind to a protein called PSCA, which is found on the surface of certain cancer cells, particularly in the prostate. When these antibodies attach to the PSCA protein, they are internalized by the cell, meaning the cell pulls the antibody inside itself. This mechanism is crucial because it allows the antibody to deliver a toxic payload directly into the cancer cell. The patent specifically claims antibodies produced by six distinct hybridoma cell lines, which are laboratory-grown cells used to mass-produce these precise antibodies.",
  "what_it_does_not_cover": [
    "Does not cover antibodies that bind to proteins other than PSCA.",
    "Does not cover antibodies that do not internalize into the cell upon binding.",
    "Does not cover general methods of cancer treatment that do not use these specific hybridoma-derived antibodies.",
    "Does not cover the PSCA protein itself, only the antibodies that target it."
  ],
  "filed": "2000-10-27",
  "granted": "2004-11-30",
  "expires": null,
  "status": "active",
  "holder": "Genentech Inc",
  "holder_url": "https://patentbrief.org/company/genentech-inc",
  "inventors": [
    {
      "name": "Lawrence A. Lasky",
      "url": "https://patentbrief.org/inventor/lawrence-a-lasky"
    },
    {
      "name": "Gilbert-Andre Keller",
      "url": "https://patentbrief.org/inventor/gilbert-andre-keller"
    },
    {
      "name": "Brigitte Devaux",
      "url": "https://patentbrief.org/inventor/brigitte-devaux"
    },
    {
      "name": "Hartmut Koeppen",
      "url": "https://patentbrief.org/inventor/hartmut-koeppen"
    }
  ],
  "times_cited": 136,
  "tags": [
    "biotech",
    "pharmaceutical"
  ],
  "abstract": "The invention provides antibodies targeted at a tumor antigen prevalent on prostate tumors and methods useful in alleviating cancers expressing the antigen, as well as nucleic acids and cells for expressing the antibodies.",
  "url": "https://patentbrief.org/patent/us/6824780/avastin-dosing",
  "markdown_url": "https://patentbrief.org/patent/us/6824780/avastin-dosing/md",
  "google_patents_url": "https://patents.google.com/patent/US6824780",
  "relatedPatents": []
}