{
  "patent_number": "US 6630507",
  "country": "US",
  "title": "Using Cannabinoids to Protect the Brain from Oxidative Stress",
  "original_title": "Cannabinoids as antioxidants and neuroprotectants",
  "summary": "A government-owned patent describing how certain non-psychoactive cannabinoids can act as antioxidants to protect brain cells from damage caused by strokes, trauma, or diseases like Alzheimer's.",
  "what_it_does": "This patent claims a method for treating diseases caused by oxidative stress—where unstable molecules damage cells—by using specific cannabinoids that do not bind to the NMDA receptor. Unlike traditional cannabinoids that cause a 'high,' the patent focuses on compounds like cannabidiol (CBD) that act as antioxidants to prevent neurological damage. The mechanism involves protecting the central nervous system during ischemic events, such as a stroke, or chronic conditions like Parkinson's disease. By avoiding NMDA receptor interaction, the method aims to provide neuroprotection without the psychoactive side effects or toxicity associated with other cannabis-derived compounds.",
  "what_it_does_not_cover": [
    "Does not cover cannabinoids that act as antagonists at the NMDA receptor.",
    "Does not cover treatments for conditions unrelated to oxidative stress or neurodegeneration.",
    "Does not claim the discovery of the cannabis plant itself, but rather a specific medical application of purified cannabinoid compounds.",
    "Does not cover psychoactive cannabinoids when used in a way that relies on their psychoactive properties."
  ],
  "filed": "1999-04-21",
  "granted": "2003-10-07",
  "expires": "2019-04-21",
  "status": "expired",
  "holder": "US Department of Health and Human Services",
  "holder_url": "https://patentbrief.org/company/us-department-of-health-and-human-services",
  "inventors": [
    {
      "name": "Julius Axelrod",
      "url": "https://patentbrief.org/inventor/julius-axelrod"
    },
    {
      "name": "Maurizio Grimaldi",
      "url": "https://patentbrief.org/inventor/maurizio-grimaldi"
    },
    {
      "name": "Aidan J. Hampson",
      "url": "https://patentbrief.org/inventor/aidan-j-hampson"
    }
  ],
  "times_cited": 78,
  "tags": [
    "biotech",
    "pharmaceutical"
  ],
  "abstract": "Cannabinoids have been found to have antioxidant properties, unrelated to NMDA receptor antagonism. This new found property makes cannabinoids useful in the treatment and prophylaxis of wide variety of oxidation associated diseases, such as ischemic, age-related, inflammatory and autoimmune diseases. The cannabinoids are found to have particular application as neuroprotectants, for example in limiting neurological damage following ischemic insults, such as stroke and trauma, or in the treatment of neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease and HIV dementia. Nonpsychoactive cannabinoids, such as cannabidoil, are particularly advantageous to use because they avoid toxicity that is encountered with psychoactive cannabinoids at high doses useful in the method of the present invention. A particular disclosed class of cannabinoids useful as neuroprotective antioxidants is formula (I) wherein the R group is independently selected from the group consisting of H, CH3, and COCH3.",
  "url": "https://patentbrief.org/patent/us/6630507/cannabinoids-as-antioxidants-and-neuroprotectants",
  "markdown_url": "https://patentbrief.org/patent/us/6630507/cannabinoids-as-antioxidants-and-neuroprotectants/md",
  "google_patents_url": "https://patents.google.com/patent/US6630507",
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}