{
  "patent_number": "US 5891653",
  "country": "US",
  "title": "Using Stress Proteins to Help the Body Accept Organ Transplants",
  "original_title": "Method of suppressing graft rejection by means of stress proteins",
  "summary": "A method for preventing organ transplant rejection by using stress proteins to teach the immune system to tolerate donor tissue.",
  "what_it_does": "This patent describes a way to stop the body from attacking a transplanted organ by using stress proteins. These proteins are naturally occurring molecules that act like a delivery system; when bound to specific antigens from the donor organ, they can be introduced to the recipient's immune system. By presenting these donor-specific markers to immune cells, the treatment aims to modulate the immune response, essentially training the body to accept the graft instead of rejecting it. The process can involve treating cells outside the body or administering the protein-antigen complex directly to the patient.",
  "what_it_does_not_cover": [
    "Does not cover general protection against cell death or mortality.",
    "Does not cover non-specific immune suppression methods like traditional steroids.",
    "Does not cover the use of stress proteins without an attached donor-specific antigen.",
    "Does not cover surgical techniques for performing the actual transplant."
  ],
  "filed": "1996-12-27",
  "granted": "1999-04-06",
  "expires": null,
  "status": "active",
  "holder": "Individual",
  "holder_url": "https://patentbrief.org/company/individual",
  "inventors": [
    {
      "name": "Derrick Cecil Attfield",
      "url": "https://patentbrief.org/inventor/derrick-cecil-attfield"
    }
  ],
  "times_cited": 15,
  "tags": [
    "biotech",
    "pharmaceutical"
  ],
  "abstract": "The present invention describes the application of specifically derived stress proteins in the modulation of certain specific immune responses in the human and animal body. This application under certain conditions may require the in vitro (out of body) treatment of certain tissues (including cells of all lineages) derived from the intended recipient body or specific donor body, in the case of organ or cell transplantation. The intracellular activity and the subsequent protection against mortality in a cell or tissue has been described in another U.S. patent, U.S. Pat. No. 5,348,945 entitled \"Method of treatment with HSP70\". The present invention differs from the aforementioned patent in that it does not describe a method for non-specific or specific protection against mortality. The invention may be employed to suppress allograft rejection and the rejection of xenografts, transplanted into human and/or animals.",
  "url": "https://patentbrief.org/patent/us/5891653/hiv-viral-load-test-bdna",
  "markdown_url": "https://patentbrief.org/patent/us/5891653/hiv-viral-load-test-bdna/md",
  "google_patents_url": "https://patents.google.com/patent/US5891653",
  "relatedPatents": []
}