{
  "patent_number": "US 5876725",
  "country": "US",
  "title": "How Vaccines Protect Pigs from Respiratory Bacteria",
  "original_title": "Actinobacillus pleuropneumoniae transferrin binding protein vaccines and uses thereof",
  "summary": "A 1999 patent describing a vaccine for swine that uses specific bacterial proteins to trigger an immune response against the lung disease caused by Actinobacillus pleuropneumoniae.",
  "what_it_does": "The patent details a vaccine composition designed to prevent pneumonia in pigs caused by the bacterium Actinobacillus pleuropneumoniae. It works by using specific transferrin binding proteins—molecules the bacteria use to steal iron from the host—as antigens to train the pig's immune system. By introducing these proteins, the vaccine helps the animal recognize and fight off the infection before it causes severe lung damage. The claims also cover the use of cytolysins, which are toxins produced by the bacteria, to further strengthen the immune response.",
  "what_it_does_not_cover": [
    "Does not cover vaccines for humans or other species besides swine",
    "Does not cover methods for treating respiratory infections caused by viruses",
    "Does not cover generic iron-binding proteins from bacteria other than A. pleuropneumoniae",
    "Does not cover diagnostic kits or methods for detecting the bacteria in the environment"
  ],
  "filed": "1996-09-19",
  "granted": "1999-03-02",
  "expires": null,
  "status": "active",
  "holder": "University of Saskatchewan",
  "holder_url": "https://patentbrief.org/company/university-of-saskatchewan",
  "inventors": [
    {
      "name": "Amalia Rossi-Campos",
      "url": "https://patentbrief.org/inventor/amalia-rossi-campos"
    },
    {
      "name": "Andrew A. Potter",
      "url": "https://patentbrief.org/inventor/andrew-a-potter"
    },
    {
      "name": "Gerald F. Gerlach",
      "url": "https://patentbrief.org/inventor/gerald-f-gerlach"
    },
    {
      "name": "Philip J. Willson",
      "url": "https://patentbrief.org/inventor/philip-j-willson"
    }
  ],
  "times_cited": 3,
  "tags": [
    "biotech",
    "pharmaceutical"
  ],
  "abstract": "Novel vaccines for use against Actinobacillus pleuropneumoniae are disclosed. The vaccines contain at least one A. pleuropneumoniae transferrin binding protein and/or one A. pleuropneumoniae cytolysin and/or one A. pleuropneumoniae APP4. Also disclosed are DNA sequences encoding these proteins, vectors including these sequences and host cells transformed with these vectors. The vaccines can be used to treat or prevent porcine respiratory infections.",
  "url": "https://patentbrief.org/patent/us/5876725/synagis-palivizumab",
  "markdown_url": "https://patentbrief.org/patent/us/5876725/synagis-palivizumab/md",
  "google_patents_url": "https://patents.google.com/patent/US5876725",
  "relatedPatents": []
}