{
  "patent_number": "US 5639476",
  "country": "US",
  "title": "How to Make Pill Coatings That Keep Medicine Stable Over Time",
  "original_title": "Controlled release formulations coated with aqueous dispersions of acrylic polymers",
  "summary": "A method for coating pills with a specific plasticized acrylic polymer that ensures the medicine releases at a steady, predictable rate, even after sitting on a shelf for months.",
  "what_it_does": "This patent describes a way to coat medicine-filled substrates, like beads or tablets, with a special acrylic polymer dispersion. The core mechanism involves curing the coated pill at a temperature above the polymer's glass transition temperature for 24 to 60 hours. This process stabilizes the coating, ensuring that the rate at which the medicine dissolves in the body remains consistent even after the pill has been stored in hot and humid conditions. By achieving this stability, the manufacturer guarantees that the drug release profile does not shift by more than 15% after a month of accelerated storage.",
  "what_it_does_not_cover": [
    "Does not cover coatings made from polymers other than ammonio-methacrylate copolymers.",
    "Does not cover formulations that are not cured at a temperature above the polymer's glass transition temperature.",
    "Does not cover coatings that do not include a permeability-enhancing agent or pore-former.",
    "Does not cover immediate-release medications that do not require a controlled release profile."
  ],
  "filed": "1995-06-02",
  "granted": "1997-06-17",
  "expires": null,
  "status": "active",
  "holder": "Euro Celtique SA",
  "holder_url": "https://patentbrief.org/company/euro-celtique-sa",
  "inventors": [
    {
      "name": "Frank Pedi, Jr.",
      "url": "https://patentbrief.org/inventor/frank-pedi-jr"
    },
    {
      "name": "Benjamin Oshlack",
      "url": "https://patentbrief.org/inventor/benjamin-oshlack"
    },
    {
      "name": "Mark Chasin",
      "url": "https://patentbrief.org/inventor/mark-chasin"
    }
  ],
  "times_cited": 1092,
  "tags": [
    "pharmaceutical",
    "mechanical"
  ],
  "abstract": "A stable solid controlled release formulation having a coating derived from an aqueous dispersion of a hydrophobic acrylic polymer includes a substrate including an active agent selected from the group consisting of a systemically active therapeutic agent, a locally active therapeutic agent, a disinfecting and sanitizing agent, a cleansing agent, a fragrance agent and a fertilizing agent, overcoated with an aqueous dispersion of the plasticized water-insoluble acrylic polymer. The formulation provides a stable dissolution of the active agent which is unchanged after exposure to accelerated storage conditions.",
  "url": "https://patentbrief.org/patent/us/5639476/nicoderm-nicotine-patch",
  "markdown_url": "https://patentbrief.org/patent/us/5639476/nicoderm-nicotine-patch/md",
  "google_patents_url": "https://patents.google.com/patent/US5639476",
  "relatedPatents": []
}