{
  "patent_number": "US 5595721",
  "country": "US",
  "title": "Using Radioactive Antibodies to Treat B-Cell Lymphoma",
  "original_title": "Radioimmunotherapy of lymphoma using anti-CD20",
  "summary": "A method for treating B-cell lymphoma by using radioactive antibodies to target cancer cells without destroying the patient's bone marrow.",
  "what_it_does": "This patent describes a three-step process to treat B-cell lymphoma using antibodies that target the CD20 protein on cancer cells. First, a small amount of radioactive antibody is injected to image the patient and see where the drug goes. Second, a dose of unlabeled antibody is given to block non-tumor binding sites, ensuring the radioactive dose hits the cancer rather than healthy tissue. Finally, a therapeutic dose of radioactive antibody is administered at a level high enough to kill cancer cells but low enough to avoid damaging the bone marrow, which eliminates the need for a stem cell transplant.",
  "what_it_does_not_cover": [
    "Does not cover treatments that require hematopoietic stem cell replacement.",
    "Does not cover antibodies that do not target the CD20 antigen.",
    "Does not cover non-radioactive immunotherapy methods.",
    "Does not cover the manufacturing process of the antibodies themselves."
  ],
  "filed": "1993-09-16",
  "granted": "1997-01-21",
  "expires": null,
  "status": "active",
  "holder": "Coulter Pharmaceutical Inc",
  "holder_url": "https://patentbrief.org/company/coulter-pharmaceutical-inc",
  "inventors": [
    {
      "name": "Mark S. Kaminski",
      "url": "https://patentbrief.org/inventor/mark-s-kaminski"
    },
    {
      "name": "Stephan D. Glenn",
      "url": "https://patentbrief.org/inventor/stephan-d-glenn"
    },
    {
      "name": "Richard L. Wahl",
      "url": "https://patentbrief.org/inventor/richard-l-wahl"
    },
    {
      "name": "Gregory M. Butchko",
      "url": "https://patentbrief.org/inventor/gregory-m-butchko"
    }
  ],
  "times_cited": 232,
  "tags": [
    "biotech",
    "pharmaceutical"
  ],
  "abstract": "Methods for the treatment of lymphoma by adminstration of a B cell-specific antibody are described. The invention encompasses providing to a patient both unlabeled antibodies and antibodies labeled with a radioisotope. A principal advantage of the method is that tumor responses can be obtained in a radiometric dose range that does not require hematopoietic stem cell replacement as an adjunct therapy.",
  "url": "https://patentbrief.org/patent/us/5595721/pcr-thermal-cycler",
  "markdown_url": "https://patentbrief.org/patent/us/5595721/pcr-thermal-cycler/md",
  "google_patents_url": "https://patents.google.com/patent/US5595721",
  "relatedPatents": []
}