{
  "patent_number": "US 5521184",
  "country": "US",
  "title": "New Pyrimidine Chemical Compounds for Treating Tumors",
  "original_title": "Pyrimidine derivatives and processes for the preparation thereof",
  "summary": "This patent describes specific new chemical compounds, called N-phenyl-2-pyrimidine-amine derivatives, designed with precise molecular structures for potential use in treating cancer.",
  "what_it_does": "This patent claims a specific group of N-phenyl-2-pyrimidine-amine chemical compounds, identified by a general chemical structure called Formula I. The claims precisely define various parts of this molecule, known as 'R' groups (R1 through R10), along with X, Y, and n. For example, R1 can be 4-pyrazinyl or 1-methyl-1H-pyrrolyl, and R2 and R3 are hydrogen or lower alkyl. Crucially, one or two of the R4-R8 positions must include a nitro group, a fluoro-substituted lower alkoxy group, or a specific radical of Formula II, which itself has detailed definitions for R9, X, Y, n, and R10. The patent abstract states these compounds can be used in the therapy of tumoral diseases. An example compound would have R1 as 4-pyrazinyl, R2 and R3 as hydrogen, and one of R4-R8 as a radical of Formula II where R10 is an aliphatic radical with at least 5 carbon atoms.",
  "what_it_does_not_cover": [
    "Does not cover pyrimidine derivatives that do not match the exact N-phenyl-2-pyrimidine-amine core structure of Formula I.",
    "Does not cover compounds where the R1 substituent is not one of the specifically listed groups, such as 4-pyrazinyl or 1-methyl-1H-pyrrolyl.",
    "Does not cover compounds where the R10 radical in Formula II has fewer than 5 carbon atoms if it is an aliphatic radical.",
    "Does not cover compounds where the R4-R8 substituents do not include at least one of the specified nitro, fluoro-substituted lower alkoxy, or Formula II radicals.",
    "Does not cover compounds where the R10 radical is an aromatic-aliphatic radical but the phenyl portion is substituted differently than described in claim 3."
  ],
  "filed": "1994-04-28",
  "granted": "1996-05-28",
  "expires": null,
  "status": "active",
  "holder": "Ciba Geigy Corp",
  "holder_url": "https://patentbrief.org/company/ciba-geigy-corp",
  "inventors": [
    {
      "name": "Jurg Zimmermann",
      "url": "https://patentbrief.org/inventor/jurg-zimmermann"
    }
  ],
  "times_cited": 564,
  "tags": [
    "pharmaceutical",
    "biotech",
    "chemistry",
    "oncology"
  ],
  "abstract": "There are described N-phenyl-2-pyrimidine-amine derivatives of formula I ##STR1## wherein R 1 is 4-pyrazinyl, 1-methyl-1H-pyrrolyl, amino- or amino-lower alkyl-substituted phenyl wherein the amino group in each case is free, alkylated or acylated, 1H-indolyl or 1H-imidazolyl bonded at a five-membered ring carbon atom, or unsubstituted or lower alkyl-substituted pyridyl bonded at a ring carbon atom and unsubstituted or substituted at the nitrogen atom by oxygen, R 2 , R 3 , R 9 , X, Y, n and R 10 are defined in claim 1 These compounds can be used, for example, in the therapy of tumoral diseases.",
  "url": "https://patentbrief.org/patent/us/5521184/gleevec-imatinib",
  "markdown_url": "https://patentbrief.org/patent/us/5521184/gleevec-imatinib/md",
  "google_patents_url": "https://patents.google.com/patent/US5521184",
  "relatedPatents": []
}