{
  "patent_number": "US 5455030",
  "country": "US",
  "title": "How to Build Smaller, Synthetic Antibody-Like Molecules for Medicine",
  "original_title": "Immunotheraphy using single chain polypeptide binding molecules",
  "summary": "This patent describes a way to create small, single-chain proteins that mimic the binding power of full-sized antibodies to deliver medicine more effectively.",
  "what_it_does": "The patent details a method for creating a single-chain polypeptide that acts like an antibody but is much smaller. It achieves this by taking the two key binding parts of a natural antibody—the light chain variable region and the heavy chain variable region—and connecting them with a flexible peptide linker. This creates one continuous protein chain rather than the complex, multi-part structure of a natural antibody. In practice, this molecule can be conjugated to a therapeutic agent, such as a drug or toxin, to target specific cells, like cancer cells, while ignoring healthy ones.",
  "what_it_does_not_cover": [
    "Does not cover full-sized, naturally occurring antibodies with two heavy and two light chains.",
    "Does not cover binding molecules that lack a peptide linker to connect the variable regions.",
    "Does not cover non-protein-based targeting molecules.",
    "Does not cover the specific therapeutic agents themselves, only the method of using the single-chain molecule as a delivery vehicle."
  ],
  "filed": "1993-04-01",
  "granted": "1995-10-03",
  "expires": "2013-04-01",
  "status": "expired",
  "holder": "Enzon Labs Inc",
  "holder_url": "https://patentbrief.org/company/enzon-labs-inc",
  "inventors": [
    {
      "name": "Robert C. Ladner",
      "url": "https://patentbrief.org/inventor/robert-c-ladner"
    },
    {
      "name": "Karl Hardman",
      "url": "https://patentbrief.org/inventor/karl-hardman"
    },
    {
      "name": "Robert E. Bird",
      "url": "https://patentbrief.org/inventor/robert-e-bird"
    }
  ],
  "times_cited": 440,
  "tags": [
    "biotech",
    "pharmaceutical"
  ],
  "abstract": "The invention pertains to a single polypeptide chain binding molecule which has binding specificity and affinity substantially similar to the binding specificity and affinity of the light and heavy chain aggregate variable region of an antibody, to genetic sequences coding therefor, and to recombinant DNA methods of producing such molecule and uses for such molecule.",
  "url": "https://patentbrief.org/patent/us/5455030/immunotheraphy-using-single-chain-polypeptide-binding-molecules",
  "markdown_url": "https://patentbrief.org/patent/us/5455030/immunotheraphy-using-single-chain-polypeptide-binding-molecules/md",
  "google_patents_url": "https://patents.google.com/patent/US5455030",
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}