{
  "patent_number": "US 5110802",
  "country": "US",
  "title": "Using Synthetic DNA Fragments to Block HIV Replication",
  "original_title": "Oligonucleotide phosphonates and method of inhibiting a human immunodeficiency virus in vitro utilizing said oligonucleotide phosphonates",
  "summary": "A 1987 patent describing a specific synthetic DNA molecule designed to stop the HIV virus from replicating by blocking a key part of its genetic code.",
  "what_it_does": "The patent describes an oligodeoxyribonucleoside methylphosphonate, a synthetic molecule that mimics DNA but is chemically modified to be more stable. This molecule is designed to bind specifically to the first splice acceptor site of the HIV tat III gene. By binding to this site, the molecule prevents the virus from producing the proteins it needs to replicate and form syncytial giant cells, which are clusters of infected cells. The patent claims both the specific sequence 3' TCTTAACC 5' and the method of using such sequences to inhibit HIV in laboratory cell cultures.",
  "what_it_does_not_cover": [
    "Does not cover naturally occurring DNA or RNA sequences.",
    "Does not cover therapeutic methods for treating human patients, as the claims are limited to in vitro applications.",
    "Does not cover other chemical modifications to DNA backbones beyond methylphosphonates.",
    "Does not cover sequences that do not target the specific tat III splice acceptor site."
  ],
  "filed": "1987-07-14",
  "granted": "1992-05-05",
  "expires": null,
  "status": "active",
  "holder": "City of Hope",
  "holder_url": "https://patentbrief.org/company/city-of-hope",
  "inventors": [
    {
      "name": "R. Bruce Wallace",
      "url": "https://patentbrief.org/inventor/r-bruce-wallace"
    },
    {
      "name": "Edouard M. Cantin",
      "url": "https://patentbrief.org/inventor/edouard-m-cantin"
    },
    {
      "name": "John J. Rossi",
      "url": "https://patentbrief.org/inventor/john-j-rossi"
    },
    {
      "name": "John A. Zaia",
      "url": "https://patentbrief.org/inventor/john-a-zaia"
    }
  ],
  "times_cited": 26,
  "tags": [
    "biotech",
    "pharmaceutical",
    "gene_editing"
  ],
  "abstract": "A method of inhibiting human immunodeficiency virus (HIV) comprising administering a therapeutically effective amount of an antiviral agent to attack the first splice acceptor site of the tat III gene of HIV.",
  "url": "https://patentbrief.org/patent/us/5110802/crixivan-indinavir",
  "markdown_url": "https://patentbrief.org/patent/us/5110802/crixivan-indinavir/md",
  "google_patents_url": "https://patents.google.com/patent/US5110802",
  "relatedPatents": []
}