{
  "patent_number": "US 5002952",
  "country": "US",
  "title": "How to Make Hard-to-Absorb Medicines Easier for the Body to Use",
  "original_title": "Readily absorbed pharmaceutical composition",
  "summary": "A method for mixing specific chemical compounds with surfactants to help the body absorb them more effectively.",
  "what_it_does": "This patent describes a way to improve how the body absorbs a class of chemicals called benzoyl urea compounds. These compounds are often difficult for the body to process because they do not dissolve well in water. By mixing these compounds with specific nonionic surfactants—substances that help bridge the gap between water and oil—and grinding them into tiny particles (0.2 to 10 micrometers), the inventors created a formula that is much easier for the body to take up. The process involves wet-milling the mixture, often using glass beads, to ensure the particles are small enough to be effective.",
  "what_it_does_not_cover": [
    "Does not cover benzoyl urea compounds outside the specific chemical structure defined in claim 1.",
    "Does not cover the use of ionic surfactants, which have a different chemical charge profile.",
    "Does not cover methods of administration that do not rely on this specific particle-size reduction process.",
    "Does not cover the synthesis of the benzoyl urea compound itself, only the composition and its preparation."
  ],
  "filed": "1989-07-27",
  "granted": "1991-03-26",
  "expires": null,
  "status": "active",
  "holder": "Green Cross Corp Japan",
  "holder_url": "https://patentbrief.org/company/green-cross-corp-japan",
  "inventors": [
    {
      "name": "Nobuo Kondo",
      "url": "https://patentbrief.org/inventor/nobuo-kondo"
    },
    {
      "name": "Kazumasa Yokoyama",
      "url": "https://patentbrief.org/inventor/kazumasa-yokoyama"
    },
    {
      "name": "Nobutoshi Yamada",
      "url": "https://patentbrief.org/inventor/nobutoshi-yamada"
    },
    {
      "name": "Tsunetaka Nakajima",
      "url": "https://patentbrief.org/inventor/tsunetaka-nakajima"
    },
    {
      "name": "Masahiro Watanabe",
      "url": "https://patentbrief.org/inventor/masahiro-watanabe"
    },
    {
      "name": "Hideo Sugi",
      "url": "https://patentbrief.org/inventor/hideo-sugi"
    },
    {
      "name": "Takahiro Haga",
      "url": "https://patentbrief.org/inventor/takahiro-haga"
    },
    {
      "name": "Toru Koyanagi",
      "url": "https://patentbrief.org/inventor/toru-koyanagi"
    }
  ],
  "times_cited": 16,
  "tags": [
    "pharmaceutical",
    "biotech"
  ],
  "abstract": "A pharmaceutical composition comprising a benzoyl urea compound having the formula: <IMAGE> (I) wherein X is a halogen atom or a nitro group, Y is a hydrogen atom, a halogen atom, a nitro group or a trifluoromethyl group, Z1 is a halogen atom or a trifluoromethyl group, Z2 is a hydrogen atom or a halogen atom, and A is a =CH-group or a nitrogen atom, and a nonionic surfactant.",
  "url": "https://patentbrief.org/patent/us/5002952/duragesic-fentanyl-patch",
  "markdown_url": "https://patentbrief.org/patent/us/5002952/duragesic-fentanyl-patch/md",
  "google_patents_url": "https://patents.google.com/patent/US5002952",
  "relatedPatents": []
}