{
  "patent_number": "US 4816567",
  "country": "US",
  "title": "Making Hybrid Antibodies from Different Animals",
  "original_title": "Recombinant immunoglobin preparations",
  "summary": "This patent describes how to create new, engineered antibodies by combining parts of antibodies from two different animal species, then growing them in a lab.",
  "what_it_does": "This patent details a method for creating \"chimeric immunoglobulins,\" which are special antibody parts made from genetic material of two different mammals. Specifically, it involves designing a DNA sequence where the \"constant region\" (the body of the antibody) matches one animal, and the \"variable region\" (the part that recognizes a target) matches a different animal (Claim 1a). This engineered DNA is then put into a \"vector\" (a delivery vehicle) and inserted into a \"host cell\" like bacteria or yeast (Claim 1b, 1c). These cells are grown in a lab, and they produce the desired chimeric antibody chains (Claim 1d, 1e). For example, a scientist could take the antigen-binding part of a mouse antibody that targets a specific cancer cell and combine it with the \"body\" part of a human antibody. This creates a new, hybrid antibody that can target the cancer but is less likely to be rejected by the human immune system.",
  "what_it_does_not_cover": [
    "Does not cover antibodies made entirely from a single mammalian species.",
    "Does not cover antibodies where the constant and variable regions come from the same mammalian species.",
    "Does not cover methods of producing antibodies that do not involve recombinant cell culture.",
    "Does not cover antibodies that are not \"chimeric\" in the sense of combining parts from different mammalian species.",
    "Does not cover naturally occurring antibodies found in any single organism."
  ],
  "filed": "1983-04-08",
  "granted": "1989-03-28",
  "expires": null,
  "status": "active",
  "holder": "Genentech Inc",
  "holder_url": "https://patentbrief.org/company/genentech-inc",
  "inventors": [
    {
      "name": "Ronald B. Wetzel",
      "url": "https://patentbrief.org/inventor/ronald-b-wetzel"
    },
    {
      "name": "Arthur D. Riggs",
      "url": "https://patentbrief.org/inventor/arthur-d-riggs"
    },
    {
      "name": "Shmuel Cabilly",
      "url": "https://patentbrief.org/inventor/shmuel-cabilly"
    },
    {
      "name": "Herbert L. Heyneker",
      "url": "https://patentbrief.org/inventor/herbert-l-heyneker"
    },
    {
      "name": "William E. Holmes",
      "url": "https://patentbrief.org/inventor/william-e-holmes"
    }
  ],
  "times_cited": 8214,
  "tags": [
    "biotech",
    "pharmaceutical",
    "gene_editing",
    "healthcare"
  ],
  "abstract": "Altered and native immunoglobulins, including constant-variable region chimeras, are prepared in recombinant cell culture. The immunoglobulins contain variable regions which are immunologically capable of binding predetermined antigens. Methods are provided for refolding directly expressed immunoglobulins into immunologically active form.",
  "url": "https://patentbrief.org/patent/us/4816567/recombinant-antibody-production-in-cho-cells",
  "markdown_url": "https://patentbrief.org/patent/us/4816567/recombinant-antibody-production-in-cho-cells/md",
  "google_patents_url": "https://patents.google.com/patent/US4816567",
  "relatedPatents": []
}